Biochemical and biological aspects of the plasminogen activation system

Methods in Enzymology , Vol

1966 • 26,261 citations

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

1987 • 1,516 citations

The induction of differentiation in teratocarcinoma stem cells by retinoic acid

1978 • 1,459 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

1985 • 1,364 citations

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

TRIAL OF TISSUE PLASMINOGEN ACTIVATOR FOR MORTALITY REDUCTION IN ACUTE MYOCARDIAL INFARCTION

1988 • 1,161 citations

On the Regulation and Control of Fibrinolysis

1980 • 1,139 citations

Plasminogen activator inhibitors

1987 • 957 citations

Plasminogen activator inhibitors

1987 • 764 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

A HAEMATOLOGIST

1989 • 567 citations

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

1988 • 561 citations

Thrombolytic Therapy: Current Status

1988 • 556 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay

1988 • 538 citations

HOME OR AWAY?

1964 • 508 citations

A Simple, Sensitive Spectrophotometric Assay for Extrinsic (Tissue-Type) Plasminogen Activator Applicable to Measurements in Plasma

1982 • 486 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

The Peptide Chains of Human Plasmin

1967 • 478 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects

1986 • 449 citations

Plasminogen activation and regulation of pericellular proteolysis

1985 • 439 citations

Mammary plasminogen activator: correlation with involution, hormonal modulation and comparison between normal and neoplastic tissue

1979 • 437 citations

Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.

1984 • 418 citations

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

1985 • 405 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Deficient t-PA Release and Elevated PA Inhibitor Levels in Patients with Spontaneous or Recurrent Deep Venous Thrombosis

1987 • 373 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

1985 • 341 citations

On the Kinetics of the Reaction between Human Antiplasmin and Plasmin

1978 • 340 citations

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.

1986 • 326 citations

Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.

1986 • 325 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

The postoperative fibrinolytic shutdown: a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma

1985 • 311 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Plasminogen activator inhibitor in the blood of patients with coronary artery disease.

1985 • 311 citations

Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells.

1986 • 310 citations

Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium

1985 • 305 citations

The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.

1984 • 303 citations

The role of proteinase in cellular invasiveness

1983 • 297 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin.

1989 • 286 citations

A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification.

1988 • 275 citations

Tissue Plasminogen Activator

1988 • 271 citations

On the specific interaction between the lysine-binding sites in plasmin and complementary sites in α2-antiplasmin and in fibrinogen

1979 • 269 citations

Measurement of plasminogen activator inhibitor 1 in biologic fluids with a murine monoclonal antibody-based enzyme-linked immunosorbent assay

1988 • 262 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937.

1986 • 249 citations

Characterization of the Cellular Binding Site for the Urokinase-type Plasminogen Activator

1989 • 248 citations

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

1987 • 247 citations

Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo

1988 • 246 citations

Plasma levels of a specific inhibitor of tissue-type plasminogen activator (and urokinase) in normal and pathological conditions

1984 • 240 citations

Plasminogen activator release during venous stasis and exercise as determined by a new specific assay

1983 • 238 citations

One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity.

1988 • 237 citations

Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.

1986 • 232 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Surface receptors for urokinase plasminogen activator

1988 • 222 citations

Diabetes and atherosclerosis ? The role of insulin

1979 • 222 citations

Thrombolytic Therapy: Current Status

1988 • 209 citations

The role of the fibrinolytic system in deep vein thrombosis.

1985 • 201 citations

Purification of a Protein from Bovine Plasma That Binds to Type 1 Plasminogen Activator Inhibitor and Prevents Its Interaction with Extracellular Matrix

1989 • 197 citations

Age dependence of tissue plasminogen activator concentrations in plasma, as studied by an improved enzyme-linked immunosorbent assay.

1986 • 195 citations

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.

1986 • 191 citations

Follicular Plasminogen Activator: Involvement in Ovulation*

1985 • 191 citations

Interaction of Plasminogen Activator Inhibitor (PAI-1) with Vitronectin

1989 • 191 citations

Determination of tissue plasminogen activator and its "fast" inhibitor in plasma.

1986 • 187 citations

Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.

1989 • 182 citations

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

1988 • 181 citations

Thrombolytic therapy in the eighties

1986 • 177 citations

Binding of plasminogen to extracellular matrix.

1986 • 175 citations

Plasminogen activator-specific inhibitors produced by human monocytes/macrophages.

1987 • 170 citations

Glucocorticoid-modulated gene expression of tissue- and urinary-type plasminogen activator and plasminogen activator inhibitor 1 and 2.

1988 • 168 citations

Enzymatic properties of the one-and two-chain form of tissue plasminogen activator

1982 • 166 citations

Receptor Mediated Binding of the Fibrinolytic Components, Plasminogen and Urokinase, to Peripheral Blood Cells

1987 • 165 citations

Plasminogen Activator Inhibitor 1 and Plasminogen Activator Inhibitor 2 in Various Disease States

1988 • 165 citations

Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin.

1988 • 158 citations

Limited cleavage of cellular fibronectin by plasminogen activator purified from transformed cells.

1987 • 147 citations

Postoperative Changes in the Plasmatic Levels of Tissue-Type Plasminogen Activator and Its Fast-Acting Inhibitor - Relationship to Deep Vein Thrombosis and Influence of Prophylaxis

1985 • 141 citations

Synthesis of Human Plasminogen by the Liver

1980 • 137 citations

Association of a plasminogen activator inhibitor (PAI-1) with the growth substratum and membrane of human endothelial cells.

1987 • 135 citations

Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin.

1984 • 134 citations

Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.

1987 • 133 citations

Isolation of a new specific plasminogen activator in hibitor from pregnancy plasma

1986 • 129 citations

The secretion of plasminogen activators by human myeloid leukemic cells in vitro

1983 • 120 citations

Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

1987 • 119 citations

A Study of the Fibrin Plate Assay of Fibrinolytic Agents

1983 • 117 citations

An anticatalytic monoclonal antibody to avian plasminogen activator: Its effect on behavior of RSV-transformed chick fibroblasts

1986 • 114 citations

Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns

1987 • 109 citations

Induction and desensitization of plasminogen activator gene expression by tumor promoters.

1985 • 103 citations

Structure of the Gene for Human Plasminogen Activator Inhibitor-2

1989 • 99 citations

Regulation of the Synthesis and Secretion of Plasminogen Activators by Endothelial Cells

1988 • 96 citations

The receptor for urokinase‐plasminogen activator

1986 • 95 citations

Fibrinolytic shut‐down after surgery: impairment of the balance between tissue‐type plasminogen activator and its specific inhibitor

1985 • 94 citations

Molecular mechanisms of fibrinolysis and their application to fibrin‐specific thrombolytic therapy

1987 • 94 citations

Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor

1983 • 93 citations

Purification of human protease nexin.

1983 • 93 citations

Identification of a site in fibrin(OGEN) which is involved in the acceleration of plasminogen activation by tissue-type plasminogen activator

1983 • 92 citations

The placental type plasminogen activator inhibitor, PAI 2

1987 • 91 citations

Localization of the binding site of tissue-type plasminogen activator to fibrin.

1986 • 91 citations

A New Method of Isolation and Some Properties of the Heavy Chain of Human Plasmin

1975 • 91 citations

Bovine plasminogen activator inhibitor 1: Specificity determinations and comparison of the active, latent, and guanidine-activated forms

1988 • 87 citations

Endotoxin induction of an inhibitor of plasminogen activator in bovine pulmonary artery endothelial cells.

1986 • 85 citations

Structure and function of human tissue‐type plasminogen activator (t‐PA)

1986 • 85 citations

Suppression of urokinase-type plasminogen activator mRNA levels in human fibrosarcoma cells and synovial fibroblasts by anti-inflammatory glucocorticoids.

1986 • 85 citations

Sandwich ELISA for t-PA antigen employing a monoclonal antibody

1986 • 79 citations

Binding of tissue plasminogen activator to human umbilical vein endothelial cells

1987 • 77 citations

Stanozolol-Induced Changes in Fibrinolysis and Coagulation in Healthy Adults

1984 • 77 citations

Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor.

1988 • 72 citations

Glucocorticoid and Cyclic Nucleotide Regulation of Plasminogen Activator and Plasminogen Activator-Inhibitor Gene Expression in Primary Cultures of Rat Hepatocytes

1989 • 72 citations

Tissue-type plasminogen activator (t-PA) : physiological and clinical aspects

1988 • 72 citations

Characterization of the dexamethasone-induced inhibitor of plasminogen activator in HTC hepatoma cells.

1986 • 72 citations

Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor.

1987 • 72 citations

The cellular target for the plasminogen activator, urokinase, in human fibroblasts - 66 000-dalton protein

1982 • 71 citations

The Fast Inhibitor of Tissue Plasminogen Activator in Plasma During Pregnancy

1984 • 70 citations

Isolation and functional characterization of the heavy and light chains of human tissue-type plasminogen activator.

1986 • 67 citations

Involvement of both heparanase and plasminogen activator in lymphoma cell‐mediated degradation of heparan sulfate in the subendothelial extracellular matrix

1986 • 67 citations

Initiation and regulation of fibrinolysis in human plasma at the plasminogen activator level

1987 • 64 citations

Gonadotropin-Releasing Hormone Induces Ovulation in Hypophysectomized Rats: Studies on Ovarian Tissue- Type Plasminogen Activator Activity, Messenger Ribonucleic Acid Content, and Cellular Localization*

1988 • 64 citations

Increased activity of plasminogen activators during involution of the rat ventral prostate

1984 • 63 citations

Plasminogen activators catalyse conversion of inhibitor from fibrosarcoma cells to an inactive form with a lower apparent molecular mass

1986 • 62 citations

Hormonal regulation of extracellular plasminogen activators and Mr ∼ 54000 plasminogen activator inhibitor in human neoplastic cell lines, studied with monoclonal antibodies

1986 • 62 citations

Glucocorticoid modulation of plasminogen activators and of one of their inhibitors in the human mammary carcinoma cell line MDA-MB-231.

1987 • 60 citations

Plasmin catalyzes binding of lipoprotein (a) to immobilized fibrinogen and fibrin

1989 • 59 citations

Plasminogen Activator Inhibitor type 1 Biosynthesis and mRNA Level are Increased by Dexamethasone in Human Fibrosarcoma Cells

1987 • 59 citations

Modulation of plasminogen activator in rodent mammary tumors by hormones and other effectors.

1983 • 57 citations

Receptor for Plasmin on Human Carcinoma Cells1

1988 • 55 citations

Plasminogen activator inhibitor type 1: cell-specific and differentiation-induced expression and regulation in human cell lines, as determined by enzyme-linked immunosorbent assay

1988 • 52 citations

Enhancement by interleukin-1 (IL-1) of plasminogen activator inhibitor (PA-I) activity in cultured human endothelial cells

1986 • 51 citations

Fundamental and clinical fibrinolysis

1988 • 49 citations

An Enhancing Effect of Poly-Lysine on the Activation of Plasminogen

1982 • 48 citations

Hormonal Stimulation Alters the Type of Plasminogen Activator Produced by Sertoli Cells1

1986 • 48 citations

Plasminogen activator inhibitor type-1 protein, mRNA and gene transcription are increased by phorbol esters in human rhabdomyosarcoma cells.

1988 • 46 citations

Interleukin 1 stimulation of synovial cell plasminogen activator production.

1986 • 46 citations

Biological Control of Tissue Plasminogen Activator-Mediated Fibrinolysis

1988 • 44 citations

Monitoring activity of fibrinolytic agents

1984 • 44 citations

Coordinate inhibition of plasminogen activator and tumor growth by hydrocortisone in mouse mammary carcinoma.

1985 • 43 citations

On the conversion of high molecular weight urokinase to the low molecular weight form by plasmin

1981 • 40 citations

Differentiation-linked secretion of urokinase and tissue plasminogen activator by normal human hemopoietic cells.

1987 • 39 citations

Studies on a form of α2-antiplasmin in plasma which does not interact with the lysine-binding sites in plasminogen

1982 • 39 citations

Plasminogen activator inhibitor type 1 biosynthesis and mRNA level are increased by dexamethasone in human fibrosarcoma cells.

1987 • 39 citations

Inherited Fibrinolytic Disorder Due to an Enhanced Plasminogen Activator Level

1984 • 38 citations

Stage-Specific Regulation of Plasminogen Activator Secretion in the Rat Seminiferous Epithelium*

1987 • 37 citations

Effect of viscous macromolecules on peritoneal plasminogen activator activity: A potential mechanism for their ability to reduce postoperative adhesion formation

1988 • 36 citations

Thrombolytic Agents in Acute Myocardial Infarction

1989 • 36 citations

Plasminogen Activators in Tissues of the Immature and Estrogen-Stimulated Rat Uterus and in Uterine Luminal Fluid: Characterization and Properties*

1983 • 36 citations

Transcriptional regulation of plasminogen activator inhibitor type-1 mRNA in Hep G2 cells by epidermal growth factor

1991 • 34 citations

The sequential, complementary and synergistic activation of fibrin-bound plasminogen by tissue plasminogen activator and pro-urokinase

1989 • 33 citations

Aprotinin inhibits urokinase but not tissue-type plasminogen activator

1988 • 32 citations

Plasminogen activation in diabetes mellitus. Kinetic analysis of plasmin formation using components isolated from the plasma of diabetic donors.

1984 • 32 citations

Fibrinolytic Activity, Autonomic Neuropathy, and Circulation in Diabetes Mellitus

1983 • 30 citations

Concepts of Clot Lysis

1986 • 30 citations

Standardization of methods for measuring plasminogen activator inhibitor activity in human plasma.

1989 • 29 citations

A direct, plasmin-independent assay for plasminogen activator

1984 • 29 citations

Activation of pro-urokinase by plasmin: Non-michaelian kinetics indicates a mechanism of negative cooperativity

1989 • 24 citations

Local synthesis of plasminogen by the seminiferous tubules of the testis

1986 • 24 citations

Alpha 2-plasmin inhibitor-plasmin complexes in synovial fluid.

1986 • 23 citations

Functional activities and nonenzymatic glycosylation of plasma proteinase inhibitors in diabetes

1986 • 22 citations

Plasminogen Activation in Diabetes mellitus

1988 • 22 citations

Tumor necrosis factor-α regulates mRNA for urokinase-type plasminogen activator and type-1 plasminogen activator inhibitor in human neoplastic cell lines

1989 • 21 citations

Human follicular fluid protease and antiprotease activities: a suggested correlation with ability of oocytes to undergo in vitro fertilization

1989 • 20 citations

A Sensitive Assay, Specific for Endothelial Cell Type Plasminogen Activator Inhibitor in Blood Plasma

1986 • 20 citations

Altered Endogenous Fibrinolysis and Biochemical Factors in Atherosclerosis

1974 • 19 citations

Standardization of methods for measuring plasminogen activator inhibitor activity in human plasma.

1989 • 19 citations

International Committee for Fibrinolysis—Kabi Prize Lecture 1986

1987 • 17 citations

Mechanism of the Stimulatory Effect of Phorbol 12-Myristate 13-Acetate on Cellular Production of Plasminogen Activator

1984 • 17 citations

Plasminogen Activation in Diabetes Mellitus: Normalization of Blood Sugar Levels Improves Impaired Enzyme Kinetics In Vitro

1985 • 15 citations

A Simple and Sensitive Assay Employing Stable Reagents for Quantification of Plasminogen Activator

1981 • 14 citations

Inhibition of plasmin by fibrinogen

1990 • 13 citations

A simple spectrophotometric assay of plasminogen activator: comparison with the fibrinolytic method

1984 • 13 citations

Identification of the inhibitor of the plasminogen activator as the major protein secreted by endothelial rat liver cells

1989 • 13 citations

Plasminogen activators as markers of tumor colonization potential.

1983 • 12 citations

Synthesis of α2-antiplasmin by rat liver cells

1982 • 12 citations

Enhancement of the Activation of Glu-Plasminogen by Urokinase in the Simultaneous Presence of Tranexamic Acid or Fibrin

1989 • 12 citations

Functional assay of plasminogen activator by hydrolysis of 14C-globin.

1986 • 12 citations

Control of Human Plasminogen Activation

1988 • 10 citations

Suppression of plasminogen activator activity by dexamethasone in cultured cardiac myocytes

1986 • 10 citations

Cell Surface Plasminogen Activation

1989 • 9 citations

Plasminogen activator activity in differentiating leukemia cells

1984 • 9 citations

Effects of penicillins and 6-aminohexanoic acid on the kinetics of human plasmin

1989 • 9 citations

Plasminogen activator activity in differentiating rat myoblasts

1986 • 9 citations

Molecular Mechanisms of Thrombolytic Therapy

1986 • 8 citations

Modulation of the urokinase receptor in human colon cell lines by N,N-dimethylformamide

1988 • 7 citations

In Vitro Inhibition of Urokinase by Penicillins

1988 • 7 citations

Plasminogen activator, fibronectin, lymphotoxin sensitivity, and natural skin reactivity relationships to guinea pig cell tumorigenicity.

1982 • 5 citations

Plasminogen activator activity and urokinase inhibitor activity in human amniotic fluid and fetal membranes

1988 • 5 citations

Kinetic analyses of the enhancement of the activities of t-pa induced by the presence of monoclonal antibody (C9-5)

1988 • 4 citations

Deleted Work

1955 • 0 citations