Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation.
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References (52)
Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*
1995 • 4,419 citations
The acute phase response
1994 • 2,927 citations
Role of insulin-like growth factors in embryonic and postnatal growth
1993 • 2,349 citations
Insulin-like growth factors and their binding proteins: biological actions
1995 • 1,976 citations
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
1993 • 1,009 citations
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain
1991 • 882 citations
Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease
1993 • 848 citations
Role of insulin-like growth factors in embryonic and postnatal growth
1993 • 644 citations
Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation.
1977 • 640 citations
Defective inflammatory response in interleukin 6-deficient mice.
1994 • 540 citations
Juvenile rheumatoid arthritis
1981 • 439 citations
On a Form of Chronic Joint Disease in Children
1897 • 391 citations
On a Form of Chronic Joint Disease in Children.
1897 • 390 citations
Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis
1991 • 364 citations
Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease
1992 • 325 citations
Growth failure in children with inflammatory bowel disease: A prospective study
1993 • 309 citations
Critically ill patients have high basal growth hormone levels with attenuated oscillatory activity associated with low levels of insulin–like growth factor‐I
1991 • 286 citations
Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis.
1994 • 237 citations
Hormonal and Nutritional Regulation of IGF-I and Its Binding Proteins
1994 • 227 citations
Interleukin 6: insights to its function in skin by overexpression in transgenic mice.
1992 • 221 citations
Interleukin 1 receptor blockade attenuates the host inflammatory response.
1990 • 216 citations
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity.
1994 • 215 citations
Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis
1996 • 202 citations
Insulinlike Growth Factor 1 Production Is Inhibited in Human Sepsis
1988 • 198 citations
Serum cytokines in juvenile rheumatoid arthritis: correlation with conventional inflammation parameters and clinical subtypes
1995 • 195 citations
Growth patterns in children with cystic fibrosis
1964 • 181 citations
IL‐6 Expression in Neurons of Transgenic Mice Causes Reactive Astrocytosis and Increase in Ramified Microglial Cells but no Neuronal Damage
1995 • 162 citations
Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease
1986 • 157 citations
Cachexia and the acute‐phase protein response in inflammation are regulated by interleukin‐6
1993 • 152 citations
Growth in Still's Disease
1956 • 148 citations
Single‐step purification and structural characterization of human interleukin‐6 produced in Esherichia coli From a T7 RNA polymerase expression vector
1991 • 139 citations
INFLAMMATORY CYTOKINE RESPONSES IN JUVENILE CHRONIC ARTHRITIS
1995 • 137 citations
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
1994 • 122 citations
Failure to Thrive/Growth Deficiency
1992 • 91 citations
Reduction in food and water intake induced by microinjection of interleukin-1β in the ventromedial hypothalamus of the rat
1994 • 90 citations
Significance of interleukin-6 in patients with inflammatory bowel disease
1991 • 90 citations
Role of interleukin-6 and transforming growth factor-β in anorexia nervosa
1994 • 84 citations
Limited involvement of interleukin‐6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin‐6 or its receptor in various murine models
1992 • 83 citations
Treatment of growth retardation in juvenile chronic arthritis with recombinant human growth hormone.
1994 • 75 citations
Insulin-like growth factor and growth hormone secretion in juvenile chronic arthritis.
1991 • 72 citations
Serum interleukin-6 levels and joint involvement in polyarticular and pauciarticular juvenile chronic arthritis.
1992 • 68 citations
Diminished concentrations of insulin-like growth factor I in cystic fibrosis.
1995 • 62 citations
Cortisol and Growth Hormone Secretion in Relation to Linear Growth: Patients with Still's Disease on Different Therapeutic Regimens
1970 • 48 citations
Insulin-like growth factors I and II in children with systemic onset juvenile arthritis.
1988 • 44 citations
Ciliary Neurotrophic Factor (CNTF) Induces Serum Amyloid A, Hypoglycaemia and Anorexia, and Potentiates IL-1 Induced Corticosterone and IL-6 Production in Mice
1995 • 43 citations
Serum IGF-I levels and growth failure in juvenile chronic arthritis.
1989 • 42 citations
DISTURBANCES OF GROWTH IN CHRONIC ARTHRITIS IN CHILDREN
1932 • 26 citations
Juvenile rheumatoid arthritis
1996 • 15 citations
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
1994 • 13 citations
Continuous systemic interleukin-1α infusion suppresses food intake without increasing lateral hypothalamic dopamine activity
1995 • 13 citations
Failure to Thrive/Growth Deficiency
1992 • 12 citations
Reduction in food and water intake induced by microinjection of interleukin-1beta in the ventromedial hypothalamus of the rat
1994 • 5 citations
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