The role of TNFa in adipocyte metabolism

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

1993 • 7,219 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

1995 • 1,316 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

1994 • 1,173 citations

"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.

1990 • 1,131 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Two TNF receptors

1992 • 1,048 citations

Adipose tissue as an endocrine and paracrine organ

1998 • 1,000 citations

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

1996 • 900 citations

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

1998 • 843 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

1997 • 798 citations

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

1994 • 792 citations

Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets

1991 • 785 citations

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

1996 • 727 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

A Molecular Basis for Insulin Resistance

1997 • 550 citations

Tumor Necrosis Factor-α-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction

1997 • 543 citations

Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates.

1993 • 543 citations

Tumor Necrosis Factor-α in Sera of Obese Patients: Fall with Weight Loss

1998 • 543 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

1996 • 505 citations

Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

1992 • 493 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)

1995 • 426 citations

Type 2 Diabetes: When Insulin Secretion Fails to Compensate for Insulin Resistance

1998 • 415 citations

Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

1997 • 405 citations

Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase

1996 • 404 citations

Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance.

1994 • 371 citations

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

1991 • 369 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

1997 • 314 citations

Serum Levels of Tumor Necrosis Factor-α Are Increased in Obese Patients with Noninsulin-Dependent Diabetes Mellitus¹

1998 • 311 citations

Tumor Necrosis Factor-α Induces Apoptosis of Human Adipose Cells

1997 • 305 citations

Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.

1996 • 301 citations

The adipocyte: Storage depot or node on the energy information superhighway?

1995 • 298 citations

Overexpression of Perilipin A and B Blocks the Ability of Tumor Necrosis Factor α to Increase Lipolysis in 3T3-L1 Adipocytes

1998 • 287 citations

Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans¹

1997 • 278 citations

Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

1997 • 277 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

The Adipocyte and Hemostatic Balance in Obesity

1998 • 270 citations

Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture

1995 • 265 citations

TNF, immunity and inflammatory disease: lessons of the past decade.

1995 • 261 citations

Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539).

1998 • 248 citations

Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo.

1987 • 240 citations

Tumor necrosis factor mimics the metabolic response to acute infection in healthy humans

1991 • 232 citations

Cell death induction by TNF: a matter of self control

1997 • 231 citations

Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals

1998 • 223 citations

Through thick and thin: Wasting, obesity, and TNFα

1993 • 223 citations

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling.

1996 • 222 citations

Differential Regulation of the p80 Tumor Necrosis Factor Receptor in Human Obesity and Insulin Resistance

1997 • 204 citations

Relation Between Plasma Tumor Necrosis Factor-α and Insulin Sensitivity in Elderly Men With Non–Insulin-Dependent Diabetes Mellitus

1998 • 201 citations

Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta.

1989 • 190 citations

TNFα-Mediated Inhibition and Reversal of Adipocyte Differentiation Is Accompanied by Suppressed Expression of PPARγ without Effects on Pref-1 Expression*

1997 • 188 citations

Differentiation between septic and postburn insulin resistance

1989 • 187 citations

Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis.

1992 • 184 citations

TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone

1997 • 183 citations

Tumor necrosis factor-alpha acutely inhibits insulin signaling in human adipocytes: implication of the p80 tumor necrosis factor receptor.

1998 • 176 citations

Human Recombinant TNF Suppresses Lipoprotein Lipase Activity and Stimulates Lipolysis in 3T3-L1 Cells1

1987 • 175 citations

Antidiabetic thiazolidinediones block the inhibitory effect of tumor necrosis factor-alpha on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells.

1995 • 170 citations

BRL 49653 blocks the lipolytic actions of tumor necrosis factor-alpha: a potential new insulin-sensitizing mechanism for thiazolidinediones.

1998 • 168 citations

Obesity and diabetes in TNF-alpha receptor- deficient mice.

1998 • 168 citations

Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase.

1994 • 160 citations

An in Vivo Model for Elucidation of the Mechanism of Tumor Necrosis Factor-α (TNF-α)-Induced Insulin Resistance: Evidence for Differential Regulation of Insulin Signaling by TNF-α

1998 • 157 citations

Sphingomyelinase and Ceramide Suppress Insulin-induced Tyrosine Phosphorylation of the Insulin Receptor Substrate-1

1996 • 153 citations

Cooperation of Both TNF Receptors in Inducing Apoptosis: Involvement of the TNF Receptor-Associated Factor Binding Domain of the TNF Receptor 75

1998 • 150 citations

Tumor necrosis factor-alpha prevents the differentiation of human adipocyte precursor cells and causes delipidation of newly developed fat cells.

1993 • 146 citations

Uptake of Long Chain Free Fatty Acids Is Selectively Up-regulated in Adipocytes of Zucker Rats with Genetic Obesity and Non-insulin-dependent Diabetes Mellitus

1997 • 138 citations

Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.

1992 • 138 citations

Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines

1998 • 137 citations

Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms

1994 • 137 citations

LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice

1997 • 125 citations

Normalization of Plasma Lipid Peroxides, Monocyte Adhesion, and Tumor Necrosis Factor-α Production in NIDDM Patients After Gliclazide Treatment

1998 • 124 citations

Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes

1996 • 124 citations

Regulation of lipoprotein lipase mRNA content in 3T3-L1 cells by tumour necrosis factor

1988 • 123 citations

Generation and Biological Characterization of Membrane-bound, Uncleavable Murine Tumor Necrosis Factor

1995 • 120 citations

Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes

1996 • 117 citations

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1998 • 112 citations

Effects of Cell-Permeable Ceramides and Tumor Necrosis Factor-α on Insulin Signaling and Glucose Uptake in 3T3-L1 Adipocytes

1998 • 112 citations

Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells.

1994 • 109 citations

Protein kinase C isoforms α, δ and θ require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)

1998 • 103 citations

Tumor Necrosis Factor-α Inversely Regulates Prostaglandin D2 and Prostaglandin E2 Production in Murine Macrophages

1997 • 98 citations

Apoptosis of Human Adipocytes in Vitro

1994 • 90 citations

Analysis of Thermal Injury-induced Insulin Resistance in Rodents

1997 • 89 citations

Pioglitazone time-dependently reduces tumour necrosis factor-α level in muscle and improves metabolic abnormalities in Wistar fatty rats

1998 • 88 citations

Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat

1995 • 84 citations

Modulating the transcriptional control of adipogenesis

1997 • 83 citations

The Dimeric and Catalytic Subunit Forms of Protein Phosphatase 2A from Rat Brain Are Stimulated by C2-Ceramide

1995 • 81 citations

A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation.

1988 • 73 citations

Effect of Tumor Necrosis Factor on Acetyl-Coenzyme A Carboxylase Gene Expression and Preadipocyte Differentiation

1988 • 72 citations

Leptin and its receptor

1997 • 68 citations

Serum tumour necrosis factor alpha and insulin resistance in gastrointestinal cancer

1992 • 68 citations

Is leptin an insulin counter‐regulatory hormone?

1997 • 67 citations

Augmented Production of Tumor Necrosis Factor-α in Obese Mice

1995 • 67 citations

Anti-Tumour Necrosis Factor-α Treatment Interferes with Changes in Lipid Metabolism in a Tumour Cachexia Model

1994 • 66 citations

Autocrine Inhibition of Leptin Production by Tumor Necrosis Factor-α (TNF-α) through TNF-α Type-I Receptorin Vitro

1998 • 65 citations

Circulating Tumor Necrosis Factor α is Elevated in Male but Not in Female Patients With Type II Diabetes Mellitus

1997 • 62 citations

Obesity Results as a Consequence of Glucocorticoid Induced Leptin Resistance

1996 • 60 citations

CCAAT/enhancer binding protein expression is rapidly extinguished in TA1 adipocyte cells treated with tumor necrosis factor.

1992 • 56 citations

In vivo regulation of acyl-CoA synthetase mRNA and activity by endotoxin and cytokines

1998 • 54 citations

Pioglitazone and Metformin Reverse Insulin Resistance Induced by Tumor Necrosis Factor-Alpha in Liver Cells

1997 • 54 citations

TNF‐α induces apoptosis in rat fetal brown adipocytes in primary culture

1997 • 53 citations

Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNFα expression

1998 • 50 citations

Recombinant human tumor necrosis factor does not inhibit lipoprotein lipase in primary cultures of isolated human adipocytes

1988 • 48 citations

Tumor necrosis factor-α induces apoptosis in rat brown adipocytes

1997 • 43 citations

Effect of Tumor Necrosis Factor‐α on Insulin‐Stimulated Mitogen‐Activated Protein Kinase Cascade in Cultured Rat Skeletal Muscle Cells

1996 • 43 citations

Effect of tumor necrosis factor-α on the phosphorylation of tyrosine kinase receptors is associated with dynamic alterations in specific protein-tyrosine phosphatases

1997 • 42 citations

MECHANISMS OF INSULIN RESISTANCE AND NEW PHARMACOLOGICAL APPROACHES TO METABOLISM AND DIABETIC COMPLICATIONS

1998 • 38 citations

Differential Regulation by Tumor Necrosis Factor-α of β1-, β2-, and β3-Adrenoreceptor Gene Expression in 3T3-F442A Adipocytes

1997 • 36 citations

Protein kinase C (PKC) ϵ enhances the inhibitory effect of TNFα on insulin signaling in HEK293 cells

1997 • 36 citations

Lipid metabolism in tumour-bearing mice:

1997 • 26 citations

Anti-TNF treatment does not reverse the abnormalities in lipid metabolism of the obese Zucker rat

1997 • 25 citations

Development of immunoassays for the detection of soluble tumour necrosis factor receptors

1991 • 21 citations

Soluble Tumor Necrosis Factor Receptors in Health and Disease

2015 • 9 citations

Positive and negative regulators of adipocyte differentiation☆

1993 • 7 citations