Involvement of the TCR Cβ FG Loop in Thymic Selection and T Cell Function

Sequences of proteins of immunological interest

1984 • 3,427 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble

1988 • 786 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).

1995 • 463 citations

The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells

1994 • 457 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

Two Human T Cell Receptors Bind in a Similar Diagonal Mode to the HLA-A2/Tax Peptide Complex Using Different TCR Amino Acids

1998 • 438 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

gamma/delta and other unconventional T lymphocytes: what do they see and what do they do?

1996 • 306 citations

Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit

1985 • 303 citations

Genetic and Mutational Analysis of the T-Cell Antigen Receptor

1990 • 275 citations

Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1

2000 • 271 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity

2000 • 203 citations

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

1995 • 196 citations

Thymocyte Development in the Absence of Pre-T Cell Receptor Extracellular Immunoglobulin Domains

1998 • 194 citations

Pillars article: antigen receptor tail clue. Nature. 1989. 338: 383-384.

2014 • 190 citations

Pairwise, cooperative and inhibitory interactions describe the assembly and probable structure of the T-cell antigen receptor.

1991 • 180 citations

Atomic structure of an alpha beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived from a mitogenic antibody

1998 • 174 citations

Mechanisms Contributing to T Cell Receptor Signaling and Assembly Revealed by the Solution Structure of an Ectodomain Fragment of the CD3ϵγ Heterodimer

2001 • 171 citations

Identification of the Receptor for Antigen and Major Histocompatibility Complex on Human Inducer T Lymphocytes

1983 • 165 citations

The CD3γ chain is essential for development of both the TCRαβ and TCRγδ lineages

1998 • 158 citations

Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.

1988 • 146 citations

Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains.

1988 • 142 citations

CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection

2000 • 137 citations

Signal strength in thymic selection and lineage commitment

2001 • 132 citations

The implications of subunit interactions for the structure of the T cell receptor‐CD3 complex

1990 • 130 citations

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex.

1991 • 129 citations

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.

1994 • 124 citations

The protein interactions of the immunoglobulin receptor family tyrosine‐based activation motifs present in the T cell receptor ζ subunits and the CD3 γ,δ and ϵ chains

1996 • 114 citations

Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment

1998 • 107 citations

Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection

1997 • 95 citations

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains.

1994 • 90 citations

T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

1997 • 88 citations

The T cell antigen receptor α and β chains interact via distinct regions with CD3 chains

1994 • 77 citations

Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.

1995 • 71 citations

One of the CD3ε Subunits within a T Cell Receptor Complex Lies in Close Proximity to the Cβ FG Loop

1998 • 68 citations

Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands

1998 • 61 citations

Functional analysis of immunoreceptor tyrosinebased activation motif (ITAM)‐mediated signal transduction: the two YxxL segments within a single CD3ζITAM are functionally distinct

1997 • 44 citations

Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis

1997 • 41 citations

Epitope dominance: evidence for reciprocal determinant spreading to glutamic acid decarboxylase in non‐obese diabetic mice

1998 • 39 citations

Double-positive T cell receptorhigh thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection

1997 • 32 citations

T cell receptor-alpha beta lacking the beta-chain V domain can be expressed at the cell surface but prohibits T cell maturation.

1992 • 31 citations

The Biological Activity of Natural and Mutant Ptα Alleles

2001 • 30 citations

Impaired Nk1.1 T Cell Development in Mice Transgenic for a T Cell Receptor β Chain Lacking the Large, Solvent-Exposed Cβ Fg Loop

1999 • 14 citations

T Cell Receptor β Chain Lacking the Large Solvent-exposed Cβ FG Loop Supports Normal α/β T Cell Development and Function in Transgenic Mice

1999 • 11 citations

TCRβ Transmembrane Tyrosines Are Required for Pre-TCR Function

2002 • 4 citations