Single-Cell PCR Analysis of TCR Repertoires Selected by Antigen In Vivo: A High Magnitude CD8 Response Is Comprised of Very Few Clones

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells

1990 • 775 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Optimal conditions for directly sequencing double-stranded PCR products with Sequenase

1990 • 357 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1993 • 298 citations

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1984 • 290 citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

1994 • 232 citations

T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region Genes

1985 • 197 citations

Molecular detection and in vivo analysis of the specific T cell response to a protein antigen

1992 • 176 citations

Localization of a T-cell receptor diversity-region element

1984 • 159 citations

Locus-specific somatic hypermutation in germinal centre T cells

1994 • 134 citations

Antigen-selected T-cell receptor diversity and self-nonself homology

1993 • 105 citations

H-2-restricted cytolytic T lymphocytes specific for HLA display T cell receptors of limited diversity.

1992 • 102 citations

H2-restricted recognition of cloned HLA class I gene products expressed in mouse cells.

1986 • 79 citations

Oligoclonal expansion of major histocompatibility complex class I-restricted cytolytic T lymphocytes during a primary immune response in vivo: direct monitoring by flow cytometry and polymerase chain reaction.

1993 • 76 citations

Monoclonal antibodies raised against engineered soluble mouse T cell receptors and specific for V_α8‐, V_β2‐ or V_β10‐bearing T cells

1991 • 75 citations

Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response.

1995 • 67 citations

Dynamic changes of accumulated T cell clonotypes during antigenic stimulation in vivo and in vitro

1994 • 49 citations

In vivo expansion of HLA-B35 alloreactive T cells sharing homologous T cell receptors: evidence for maintenance of an oligoclonally dominated allospecificity by persistent stimulation with an autologous MHC/peptide complex.

1995 • 43 citations

Analysis of individual immunoglobulin λ light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal‐center B cell somatic mutation

1994 • 31 citations

T cell receptor selection by and recognition of two class I major histocompatibility complex-restricted antigenic peptides that differ at a single position.

1993 • 29 citations

Comparison of the Jβ gene usage among different T cell receptor Vβ families in spleens of C57BL/6 mice

1994 • 21 citations

Conserved V(D)J junctional sequence of cross‐reactive cytotoxic T cell receptor idiotype and the effect of a single amino acid substitution

1991 • 19 citations

Selection of T cell receptor variable gene‐encoded amino acids on the third binding site loop: a factor influencing variable chain selection in a T cell response

1995 • 16 citations

Sequencing Double-Stranded Linear DNA with Sequenase and [α-<SUP>35</SUP>S] d.ATP

2003 • 5 citations