Immunoproteasomes Shape Immunodominance Hierarchies of Antiviral Cd8+ T Cells at the Levels of T Cell Repertoire and Presentation of Viral Antigens

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis

1999 • 1,872 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

A gated channel into the proteasome core particle.

2000 • 791 citations

Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia

1998 • 685 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible Subunits

1998 • 430 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

Dissecting the Multifactorial Causes of Immunodominance in Class I–Restricted T Cell Responses to Viruses

2000 • 312 citations

The MHC class I ligand‐generating system: roles of immunoproteasomes and the interferon‐4gMY‐inducible proteasome activator PA28

1998 • 288 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen

1993 • 181 citations

Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

2000 • 161 citations

Overexpression of the Proteasome Subunits LMP2, LMP7, and MECL-1, But Not PA28α/β, Enhances the Presentation of an Immunodominant Lymphocytic Choriomeningitis Virus T Cell Epitope

2000 • 121 citations

MHC Class I Antigen Processing of an Adenovirus CTL Epitope Is Linked to the Levels of Immunoproteasomes in Infected Cells

2000 • 117 citations

MHC class I-associated peptides produced from endogenous gene products with vastly different efficiencies.

1997 • 110 citations

Differential Influence on Cytotoxic T Lymphocyte Epitope Presentation by Controlled Expression of Either Proteasome Immunosubunits or Pa28

2000 • 106 citations

The major‐histocompatibility‐complex‐encoded β‐type proteasome subunits LMP2 and LMP7

1993 • 61 citations

TAP1‐deficient mice select a CD8⁺ T cell repertoire that displays both diversity and peptide specificity

1996 • 41 citations

Sequence information within proteasomal prosequences mediates efficient integration of β-subunits into the 20 s proteasome complex

1999 • 37 citations

Naturally Occurring TAP-Dependent Specific T-Cell Tolerance for a Variant of an Immunodominant Retroviral Cytotoxic T-Lymphocyte Epitope

2000 • 6 citations