The Drosophila Tumor Necrosis Factor Receptor-associated Factor-1 (DTRAF1) Interacts with Pelle and Regulates NFκB Activity

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1997 • 1,316 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

TRAF6 is a signal transducer for interleukin-1

1996 • 1,287 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 • 1,043 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

1995 • 728 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

Functional cDNA libraries from Drosophila embryos

1988 • 604 citations

Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death

1998 • 597 citations

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 • 581 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase

1998 • 425 citations

Structure-Function Analysis of Bcl-2 Protein

1995 • 419 citations

Structural basis for self-association and receptor recognition of human TRAF2

1999 • 355 citations

TRAF5, an Activator of NF-κB and Putative Signal Transducer for the Lymphotoxin-β Receptor

1996 • 343 citations

An ancient system of host defense

1998 • 333 citations

Anatomy of TRAF2

1996 • 302 citations

A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis

1998 • 272 citations

CD40−Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions: Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization

1998 • 248 citations

Targeted Disruption of TRAF3 Leads to Postnatal Lethality and Defective T-Dependent Immune Responses

1996 • 239 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Presence of a New Conserved Domain in CART1, a Novel Member of the Tumor Necrosis Factor Receptor-associated Protein Family, Which Is Expressed in Breast Carcinoma

1995 • 229 citations

pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo

1993 • 210 citations

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1

1998 • 203 citations

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

1999 • 200 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube

1999 • 170 citations

A Drosophila TNF-receptor-associated factor (TRAF) binds the Ste20 kinase Misshapen and activates Jun kinase

1999 • 152 citations

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.

1994 • 125 citations

Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity.

1991 • 113 citations

Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation

1999 • 98 citations

Activation of NF-κB/Rel by CD40 Engagement Induces the Mouse Germ Line Immunoglobulin Cγ1 Promoter

1996 • 85 citations

Signalling by CD95 and TNF receptors: Not only life and death

1999 • 82 citations

Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos

1995 • 71 citations

TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues.

1998 • 68 citations

Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube

1998 • 54 citations

Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor

1995 • 43 citations

Formation and Biochemical Characterization of Tube/Pelle Death Domain Complexes: Critical Regulators of Postreceptor Signaling by the Drosophila Toll Receptor

1999 • 24 citations