An ancient system of host defense

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

1996 • 3,854 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

PLANT DISEASE RESISTANCE GENES

1997 • 1,191 citations

Molecular Genetics of Plant Disease Resistance

1995 • 932 citations

IRAK: A Kinase Associated with the Interleukin-1 Receptor

1996 • 894 citations

A CONSERVED SIGNALING PATHWAY: The Drosophila Toll-Dorsal Pathway

1996 • 822 citations

Signal perception and transduction in plant defense responses.

1997 • 648 citations

Innate immunity of insects

1995 • 549 citations

NF-κB and Rel Proteins in Innate Immunity

1995 • 435 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

Immune reactions in Drosophila and other insects: a model for innate immunity

1993 • 417 citations

Plant disease resistant genes

1997 • 366 citations

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

1996 • 357 citations

SIGNALING PATHWAYS THAT ESTABLISH THE DORSAL-VENTRAL PATTERN OF THE DROSOPHILA EMBRYO

1995 • 348 citations

The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense

1997 • 277 citations

Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.

1990 • 258 citations

κB-like Motifs Regulate the Induction of Immune Genes in Drosophila

1993 • 229 citations

The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

1994 • 141 citations

The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family¹

1997 • 135 citations

Molecular characterization and modular analysis of human MyD88.

1996 • 110 citations

The dorsal-related immunity factor, Dif, is a sequence-specific trans-activator of Drosophila Cecropin gene expression.

1995 • 109 citations

Collectins: Collectors of microorganisms for the innate immune system

1997 • 96 citations

Molecular evolution of the vertebrate immune system

1997 • 91 citations

A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B.

1993 • 88 citations

Insect Immunity: The Diptericin Promoter Contains Multiple Functional Regulatory Sequences Homologous to Mammalian Acute-Phase Response Elements

1993 • 62 citations

5′ upstream sequences of MyD88, an IL-6 primary response gene in M1 cells: detection of functional IRF-1 and Stat factors binding sites

1995 • 42 citations