The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2

1991 • 688 citations

Monoclonal antibodies to mitotic cells.

1983 • 609 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization

1989 • 392 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

cdc2 phosphorylation is required for its interaction with cyclin.

1991 • 338 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase

1988 • 324 citations

Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans.

1987 • 288 citations

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

1988 • 285 citations

Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope.

1994 • 257 citations

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans

1991 • 243 citations

A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.

1992 • 185 citations

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

1992 • 145 citations

A mutation in aspergillus nidulans that blocks the transition from interphase to prophase

1983 • 138 citations

Activation of the nimA protein kinase plays a unique role during mitosis that cannot be bypassed by absence of the bimE checkpoint.

1991 • 135 citations

Premature chromatin condensation upon accumulation of NIMA.

1994 • 132 citations

The substrates of the cdc2 kinase.

1991 • 115 citations

Guanylyl cyclase receptors.

1994 • 114 citations

Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit.

1995 • 100 citations

An extra copy of nimEcyclinB elevates pre-MPF levels and partially suppresses mutation of nimTcdc25 in Aspergillus nidulans.

1992 • 91 citations

A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans

1994 • 85 citations

Characterization of somatostatin receptors on human neuroblastoma tumors.

1994 • 83 citations

Mitosis-specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity.

1989 • 77 citations

Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

1993 • 76 citations

Properties and regulation of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans.

1993 • 72 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe P34cdc2 function

1992 • 66 citations

Isolation of a novel protein kinase-encoding gene from yeast by oligodeoxyribonucleotide probing

1990 • 49 citations

The substrates of the cdc2 kinase.

1991 • 38 citations

Multiple forms of maturation-promoting factor in unfertilized Xenopus eggs.

1991 • 21 citations