Requirement of ATM in Phosphorylation of the Human p53 Protein at Serine 15 following DNA Double-Strand Breaks

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

In vivo ubiquitination and proteasome-mediated degradation of p53(1).

1996 • 643 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2.

1996 • 586 citations

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

1995 • 540 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1998 • 471 citations

Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

1993 • 253 citations

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

1994 • 253 citations

U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle.

1994 • 227 citations

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

1998 • 133 citations

Nijmegen Breakage Syndrome Cells Fail To Induce the p53-Mediated DNA Damage Response following Exposure to Ionizing Radiation

1997 • 119 citations

DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.

1997 • 85 citations

Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.

1994 • 79 citations

UVs syndrome, a new general category of photosensitive disorder with defective DNA repair, is distinct from xeroderma pigmentosum variant and rodent complementation group I.

1995 • 67 citations

Nuclear Accumulation of p53 in Normal Human Fibroblasts Is Induced by Various Cellular Stresses which Evoke the Heat Shock Response, Independently of the Cell Cycle

1995 • 60 citations

Induction of chromosomal damage by restriction endonuclease in CHO cells porated with streptolysin O

1992 • 37 citations

Microinjection of partially purified protein factor restores DNA damage specifically in group A of xeroderma pigmentosum cells.

1986 • 32 citations

Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells.

1994 • 29 citations

Determination of the chromosomal site for the human radiosensitive ataxia telangiectasia gene by chromosome transfer

1991 • 17 citations