cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

AP-1 function and regulation

1997 • 2,833 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1995 • 1,252 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Programmed cell death

1974 • 966 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor.

1993 • 535 citations

Topoisomerase-targeting antitumor drugs

1989 • 441 citations

Protein Serine/Threonine Phosphatases—New Avenues for Cell Regulation

1994 • 424 citations

Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29).

1982 • 348 citations

cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor.

1988 • 312 citations

Intracellular Alkalinization Suppresses Lovastatin-induced Apoptosis in HL-60 Cells through the Inactivation of a pH-dependent Endonuclease

1995 • 306 citations

Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification.

1993 • 286 citations

Oncogenes and cell death

1994 • 266 citations

Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes

1994 • 211 citations

Frequent mutations in the p53 gene in human myeloid leukemia cell lines

1992 • 197 citations

Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells

1995 • 186 citations

The Involvement of Protein Phosphatases in the Activation of ICE/CED-3 Protease, Intracellular Acidification, DNA Digestion, and Apoptosis

1996 • 158 citations

Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.

1995 • 158 citations

Chemotherapy-Induced Apoptosis

1997 • 155 citations

Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.

1991 • 137 citations

Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

1995 • 137 citations

Adenosine receptor-mediated accumulation of cyclic AMP-induced T-lymphocyte death through internucleosomal DNA cleavage.

1990 • 137 citations

The Cooperative Interaction of Two Different Signaling Pathways in Response to Bufalin Induces Apoptosis in Human Leukemia U937 Cells

1996 • 136 citations

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

1991 • 120 citations

Apoptosis and Its Modulation in Human Promyelocytic HL-60 Cells Treated with DNA Topoisomerase I and II Inhibitors

1993 • 113 citations

Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP‐ribose)polymerase (PARP) cleavage and apoptosis

1996 • 96 citations

Specific suppression by prostaglandin E2 of activation-induced apoptosis of human CD4+CD8+ T lymphoblasts.

1995 • 90 citations

Nuclear c-Myc Plays an Important Role in the Cytotoxicity of Tumor Necrosis Factor Alpha in Tumor Cells

1994 • 89 citations

Apoptosis in Burkitt lymphoma cells is driven by c-myc.

1993 • 77 citations

Elevations in cytosolic free Ca2+ are not required to trigger apoptosis in human leukaemia cells

1992 • 65 citations

Cyclic AMP potentiates glucocorticoid‐induced endogenous endonuclease activation in thymocytes ¹

1993 • 59 citations

cAMP analogs prevent activation-induced apoptosis of T cell hybridomas.

1993 • 56 citations

Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways.

1994 • 53 citations

Differences between drug-sensitive and -resistant human leukemic CEM cells in c-jun expression, AP-1 DNA-binding activity, and formation of Jun/Fos family dimers, and their association with internucleosomal DNA ladders after treatment with VM-26.

1994 • 44 citations

Apoptosis : pharmacological implications and therapeutic opportunities

1997 • 42 citations

cAMP increasing agents prevent the stimulation of heat-shock protein 70 (HSP70) gene expression by cadmium chloride in human myeloid cell lines

1995 • 38 citations

Cell Death in the Myeloid Lineage

1994 • 36 citations

Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action

1997 • 31 citations

Heat-shock and cadmium chloride increase the vimentin mRNA and protein levels in U-937 human promonocytic cells

1997 • 28 citations

Sodium butyrate inhibits the phosphorylation of the retinoblastoma gene product in mouse fibroblasts by a transcription-dependent mechanism

1996 • 27 citations

Etoposide-induced differentiation of U937 promonocytic cells: AP-1-dependent gene expression and protein kinase C activation.

1994 • 18 citations

Evidence against the hypothesis that BCL-2 inhibits apoptosis through an anti-oxidant effect

1997 • 17 citations

cAMP activates Na+H+ antiporter in murine macrophages

1989 • 12 citations