Hydrogen Peroxide-Induced Activation of SAPK/JNK Regulated by Phosphatidylinositol 3-Kinase in Chinese Hamster V79 Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

MEKK1/JNK signaling stabilizes and activates p53

1998 • 521 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

Enhancement of Fibroblast Collagenase (Matrix Metalloproteinase-1)Gene Expression by Ceramide Is Mediated by Extracellular Signal-regulated and Stress-activated Protein Kinase Pathways

1998 • 209 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor-Induced Activation of the c-Jun N-Terminal Kinase Signaling Pathway

1997 • 133 citations

Microinjection of activated phosphatidylinositol-3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway

1998 • 128 citations

Stimulation of Stress-activated Protein Kinase and p38 HOG1 Kinase in Murine Keratinocytes following Photodynamic Therapy with Benzoporphyrin Derivative

1996 • 114 citations

Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts

1997 • 99 citations

Sarcoplasmic Reticulum Ca2+-Pump Dysfunction in Rat Cardiomyocytes Briefly Exposed to Hydoxyl Radicals

1997 • 97 citations

Syk-dependent and -independent Signaling Cascades in B Cells Elicited by Osmotic and Oxidative Stress

1997 • 85 citations

Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase

1995 • 74 citations

Identification of Oxidation-Sensitive Peptides within the Cytoplasmic Domain of the Sarcoplasmic Reticulum Ca²⁺-ATPase

1997 • 74 citations

Requirement of Phosphatidylinositol-3 Kinase for Activation of JNK/SAPKs by PDGF

1997 • 69 citations

Metabolic Oxidative Stress-induced HSP70 Gene Expression Is Mediated through SAPK Pathway

1998 • 67 citations

Oxidative damage to sarcoplasmic reticulum Ca2+-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation

1996 • 62 citations

UV Irradiation Induces the Murine Urokinase-Type Plasminogen Activator Gene via the c-Jun N-Terminal Kinase Signaling Pathway: Requirement of an AP1 Enhancer Element

1998 • 59 citations

Cyclic AMP Inhibition of Thrombin-induced Growth in Vascular Smooth Muscle Cells Correlates with Decreased JNK1 Activity and c-Jun Expression

1996 • 58 citations

Glutathione is a Cofactor for H2O2-Mediated Stimulation of Ca2+-Induced Ca2+ Release in Cardiac Myocytes

1998 • 55 citations

Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells

1999 • 50 citations

Ceramide and Cyclic Adenosine Monophosphate (cAMP) Induce cAMP Response Element Binding Protein Phosphorylation via Distinct Signaling Pathways While Having Opposite Effects on Myeloid Cell Survival

1999 • 49 citations

Oxidative Modulation of Cyclic AMP-Dependent Protein Kinase in Human Fibroblasts: Possible Role in Psoriasis

1997 • 46 citations

Protein Kinase C and Protein Kinase A Inhibit Calcium-dependent but not Stress-dependent c-Jun N-terminal Kinase Activation in Rat Liver Epithelial Cells

1997 • 45 citations

Calcium vs. iron-mediated processes in hydrogen peroxide toxicity to l929 cells: effects of glucose

1998 • 36 citations

A Novel Aspect of Photodynamic Action: Induction of Recurrent Spikes in Cytosolic Calcium Concentration

1997 • 26 citations

Benzophenone-Sensitized Photooxidation of Sarcoplasmic Reticulum Membranes

1997 • 15 citations

Concentration-Dependent Modes of Cell Death in Chinese Hamster V79 Cells after Treatments with H2O2.

1997 • 15 citations