ESCAPE OF HUMAN IMMUNODEFICIENCY VIRUS FROM IMMUNE CONTROL

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 ⁺ T Cells

1995 • 2,890 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

HIV Population Dynamics in Vivo: Implications for Genetic Variation, Pathogenesis, and Therapy

1995 • 1,997 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Immunological Memory and Protective Immunity: Understanding Their Relation

1996 • 1,771 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

MHC ligands and peptide motifs: first listing

1995 • 1,674 citations

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

1981 • 1,603 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Genotypic and Phenotypic Characterization of HIV-1 Patients with Primary Infection

1993 • 1,258 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

Population Dynamics of Immune Responses to Persistent Viruses

1996 • 1,218 citations

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

1997 • 1,206 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

Virologic and Immunologic Characterization of Long-Term Survivors of Human Immunodeficiency Virus Type 1 Infection

1995 • 1,044 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection

1996 • 959 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.

1996 • 705 citations

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

1997 • 696 citations

Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant

1990 • 665 citations

Relative resistance to HIV–1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high–risk sexual exposures

1996 • 656 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

Adaptive Evolution of Human Immunodeficiency Virus-Type 1 During the Natural Course of Infection

1996 • 578 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

Antigenic Diversity Thresholds and the Development of AIDS

1991 • 531 citations

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.

1992 • 519 citations

Molecular mechanisms of variation in influenza viruses

1982 • 484 citations

Large clonal expansions of CD8+ T cells in acute infectious mononucleosis

1996 • 478 citations

Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection

1993 • 474 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

1995 • 438 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

1994 • 418 citations

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

1995 • 383 citations

Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes

1993 • 365 citations

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

1995 • 344 citations

Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.

1991 • 330 citations

Antigenic oscillations and shifting immunodominance in HIV-1 infections

1995 • 325 citations

New Concepts in the Immunopathogenesis of HIV Infection

1995 • 323 citations

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein

1991 • 303 citations

Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

1994 • 289 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide.

1991 • 286 citations

In vivo estimates of division and death rates of human T lymphocytes.

1995 • 276 citations

Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.

1995 • 268 citations

HLA-A11 Epitope Loss Isolates of Epstein-Barr Virus From a Highly A11 ⁺ Population

1993 • 255 citations

Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes.

1987 • 251 citations

Novel, Cross-Restricted, Conserved, and Immunodominant Cytotoxic T Lymphocyte Epitopes in Slow Progressors in HIV Type 1 Infection

1996 • 241 citations

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

1995 • 236 citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

1994 • 232 citations

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

1994 • 226 citations

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes

1996 • 222 citations

Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.

1994 • 221 citations

HLA HAPLOTYPE A1 B8 DR3 AS A RISK FACTOR FOR HIV-RELATED DISEASE

1988 • 221 citations

Characterization of HIV-1 neutralization escape mutants

1989 • 220 citations

Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1

1994 • 219 citations

A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection

1990 • 210 citations

HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes

1994 • 209 citations

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.

1994 • 175 citations

T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues.

1994 • 164 citations

Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors.

1995 • 163 citations

Mechanisms for the Inhibition of HIV Replication by Interferons-α, -β, and -γ, in Primary Human Macrophages

1993 • 148 citations

Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution

1991 • 140 citations

Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes and analysis of the effects of sequence variation.

1992 • 139 citations

Antagonist HIV-1 Gag Peptides Induce Structural Changes in HLA B8

1996 • 135 citations

Recruitment and proliferation of CD8+ T cells in respiratory virus infections.

1995 • 130 citations

How HIV Defeats the Immune System

1995 • 126 citations

Recognition of influenza A matrix protein by HLA-A2-restricted cytotoxic T lymphocytes. Use of analogues to orientate the matrix peptide in the HLA-A2 binding site.

1988 • 121 citations

Recognition of a highly conserved region of human immunodeficiency virus type 1 gp120 by an HLA-Cw4-restricted cytotoxic T-lymphocyte clone

1993 • 112 citations

High frequency of memory and effector gag specific cytotoxic T lymphocytes in HIV seropositive individuals

1990 • 110 citations

Cytotoxic T Lymphocyte Lysis Inhibited by Viable HIV Mutants

1995 • 107 citations

Epitope-dependent Selection of Highly Restricted or Diverse T Cell Receptor Repertoires in Response to Persistent Infection by Epstein-Barr Virus

1997 • 106 citations

Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro.

1993 • 106 citations

Conservation of T cell receptor usage by HLA B27‐restricted influenza‐specific cytotoxic T lymphocytes suggests a general pattern for antigen‐specific major histocompatibility complex class I‐restricted responses

1993 • 104 citations

HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.

1986 • 100 citations

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

1995 • 94 citations

Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

1995 • 91 citations

Change in tropism upon immune escape by human immunodeficiency virus

1995 • 89 citations

In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.

1991 • 86 citations

Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.

1995 • 81 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.

1992 • 76 citations

Peptide selection by class I molecules of the major histocompatibility complex

1993 • 74 citations

The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus

1995 • 74 citations

V3 variability can influence the ability of an antibody to neutralize or enhance infection by diverse strains of human immunodeficiency virus type 1.

1993 • 67 citations

Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope.

1995 • 65 citations

HIV Receptors and the Pathogenesis of AIDS

1996 • 64 citations

Rates of amino acid change in the envelope protein correlate with pathogenicity of primate lentiviruses

1993 • 59 citations

CTL Escape Viral Variants

1995 • 59 citations

Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.

1991 • 58 citations

The immunology of primary HIV infection: which immune responses control HIV replication?

1995 • 58 citations

Immunogenic HIV variant peptides that bind to HLA-B8 can fail to stimulate cytotoxic T lymphocyte responses.

1995 • 57 citations

Antagonistic effect of interferon-gamma on tat-induced transactivation of HIV long terminal repeat.

1992 • 54 citations

Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

1994 • 54 citations

A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients.

1994 • 51 citations

Development of vivo of genetic variability of simian immunodeficiency virus.

1991 • 45 citations

AIDS Pathogenesis: A Finite Immune Response to Blame?

1996 • 43 citations

HLA‐dependent variations in human immunodeficiency virus Nef protein alter peptide/HLA binding

1995 • 41 citations

CD8 independence and specificity of cytotoxic T lymphocytes restricted by HLA-Aw68. 1

1991 • 39 citations

Th1 cells specific for HIV-1 gag p24 are less efficient than Th0 cells in supporting HIV replication, and inhibit virus replication in Th0 cells.

1995 • 38 citations

Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes

1994 • 36 citations

HIV and HLA: Confusion or complexity?

1996 • 35 citations

Few peptides dominate cytotoxic T lymphocyte responses to single and multiple minor histocompatibility antigens

1993 • 35 citations

Inhibition of human immunodeficiency virus type 1-induced cell fusion by recombinant human interferons

1991 • 28 citations

Evolution of pathogenic viruses with special reference to the rates of synonymous and nonsynonymous substitutions.

1994 • 28 citations

Influenza A virus—a model for viral antigen presentation to cytotoxic T lymphocytes

1996 • 28 citations

Endogenous ecotropic and recombinant MCF mouse retroviral variation and escape from antiviral CTL

1996 • 11 citations

Functional Consequences of Mutations in HIV-1 Gag p55 Selected by CTL Pressure

1994 • 7 citations

Association of the TNF −238 promoter polymorphism with susceptibility to tuberculosis and malaria in Africa

1996 • 7 citations

Th2-mediated HIV1 virostatic state: macrophage-specific regulation in vitro

1994 • 7 citations

Introduction: Presentation of viral antigens to cytotoxic T cells

1996 • 4 citations