Interleukin-10 inhibits initial reverse transcription of human immunodeficiency virus type 1 and mediates a virostatic latent state in primary blood-derived human macrophages in vitro

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1984 • 3,566 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.

1989 • 544 citations

Impaired interleukin 12 production in human immunodeficiency virus-infected patients.

1994 • 435 citations

IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.

1992 • 422 citations

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus.

1994 • 393 citations

The macrophage in the persistence and pathogenesis of HIV infection

1989 • 365 citations

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

1991 • 326 citations

IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor.

1992 • 229 citations

Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection.

1993 • 217 citations

Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophages.

1992 • 183 citations

Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro.

1993 • 106 citations

The Role of Monocyte/Macrophages and Cytokines in the Pathogenesis of HIV Infection

1992 • 75 citations

Activation of infectious virus from latent human immunodeficiency virus infection of monocytes in vivo.

1992 • 72 citations

Recombinant interleukin 4 stimulates human immunodeficiency virus production by infected monocytes and macrophages

1992 • 61 citations

The Kinetics of Human Immunodeficiency Virus Reverse Transcription Are Slower in Primary Human Macrophages Than in a Lymphoid Cell Line

1994 • 61 citations

HIV-1 induces tumour necrosis factor and IL-1 gene expression in primary human macrophages independent of productive infection

1994 • 61 citations

PCR analysis of HIV1 infection of macrophages: virus entry is CD4-dependent

1993 • 18 citations