Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection

PHYLIP-Phylogeny inference package (Version 3.2)

1989 • 17,674 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

1992 • 1,059 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1

1991 • 871 citations

Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection

1991 • 851 citations

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule

1992 • 769 citations

Biologic Features of HIV-1 That Correlate with Virulence in the Host

1988 • 679 citations

Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant

1990 • 665 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations

1989 • 655 citations

Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein.

1989 • 628 citations

Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120.

1988 • 626 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers

1990 • 605 citations

Selective Transmission of Human Immunodeficiency Virus Type-1 Variants from Mothers to Infants

1992 • 598 citations

Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism

1992 • 594 citations

HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain

1990 • 589 citations

DNA recombination during PCR

1990 • 583 citations

Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 gene

1991 • 525 citations

Human immunodeficiency virus type 1 neutralization epitope with conserved architecture elicits early type-specific antibodies in experimentally infected chimpanzees.

1988 • 514 citations

Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution

1992 • 501 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Cell-Mediated Immune Response to Human Immunodeficiency Virus (HIV) Type 1 in Seronegative Homosexual Men with Recent Sexual Exposure to HIV-1

1992 • 392 citations

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

1991 • 326 citations

Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

1990 • 306 citations

Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1

1990 • 305 citations

HIV-1 genomic rna diversification following sexual and parenteral virus transmission

1992 • 298 citations

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo

1992 • 292 citations

Biologically diverse molecular variants within a single HIV-1 isolate

1988 • 285 citations

Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.

1991 • 272 citations

Viral Phenotype and Immune Response in Primary Human Immunodeficiency Virus Type 1 Infection

1992 • 268 citations

Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient.

1992 • 236 citations

Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease.

1992 • 231 citations

Concurrent evolution of human immunodeficiency virus type 1 in patients infected from the same source: rate of sequence change and low frequency of inactivating mutations

1990 • 222 citations

Discontinuous sequence change of human immunodeficiency virus (HIV) type 1 env sequences in plasma viral and lymphocyte-associated proviral populations in vivo: implications for models of HIV pathogenesis

1991 • 199 citations

Risk of Human Immunodeficiency Virus (HIV-1) Infection Among Laboratory Workers

1988 • 182 citations

Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120

1992 • 175 citations

Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages

1991 • 160 citations

Integrated proviral human immunodeficiency virus type 1 is present in CD4+ peripheral blood lymphocytes in healthy seropositive individuals

1989 • 157 citations

Host range mutant of human immunodeficiency virus type 1: modification of cell tropism by a single point mutation at the neutralization epitope in the env gene

1991 • 154 citations

Errors in the Polymerase Chain Reaction

1988 • 153 citations

Evolution of sequences encoding the principal neutralization epitope of human immunodeficiency virus 1 is host dependent, rapid, and continuous.

1990 • 143 citations

HUMAN T-LYMPHOTROPIC VIRUS TYPE III (HTLV-III) INFECTION IN SERONEGATIVE HAEMOPHILIACS AFTER TRANSFUSION OF FACTOR VIII

1985 • 141 citations

Naturally occurring mutations within HIV-1 V3 genomic RNA lead to antigenic variation dependent on a single amino acid substitution

1991 • 140 citations

Rapid generation of sequence variation during primary HIV-1 infection

1992 • 127 citations

Type-Restricted Neutralization of Molecular Clones of Human Immunodeficiency Virus

1988 • 115 citations

Detection, quantification and sequencing of HIV-1 from the plasma of seropositive individuals and from factor VIII concentrates

1991 • 99 citations

Immunodominance and antigenic variation of the principal neutralization domain of HIV-1

1991 • 97 citations

Exposure to Human Immunodeficiency Virus Type I-Specific T Helper Cell Responses before Detection of Infection by Polymerase Chain Reaction and Serum Antibodies

1991 • 93 citations

Specificity and Function of the Individual Amino Acids of an Important Determinant of Human Immunodeficiency Virus Type 1 that Induces Neutralizing Activity

1989 • 82 citations

Simian immunodeficiency virus is restricted to a subset of blood CD4+ lymphocytes that includes memory cells.

1990 • 53 citations

Independent fluctuation of human immunodeficiency virus type 1 rev and gp41 quasispecies in vivo

1991 • 53 citations

Generation of neutralization-resistant HIV-1 in vitro due to amino acid interchanges of third hypervariable env region.

1990 • 52 citations

Evolution of the Structural Proteins of Human Immunodeficiency Virus: Selective Constraints on Nucleotide Substitution

1988 • 45 citations

HIV-1 viral DNA load in peripheral blood mononuclear cells from seroconverters and long-term infected individuals

1992 • 42 citations

Assessment of human immunodeficiency virus expression in cocultures of peripheral blood mononuclear cells from healthy seropositive subjects

1988 • 42 citations

Lack of HIV-1 V3 region sequence diversity in two haemophiliac patients infected with a putative biologic clone of HIV-1

1991 • 30 citations

Conserved Sequence and Structural Elements in the HIV-1 Principal Neutralizing Determinant: Further Clarifications

1991 • 28 citations

Graded cytopathogenicity of the human immunodeficiency virus (HIV) in the course of HIV infection

1990 • 26 citations