Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen.

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Antigen Recognition by Class I-Restricted T Lymphocytes

1989 • 1,207 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

1994 • 553 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

1991 • 413 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Presentation of viral antigen controlled by a gene in the major histocompatibility complex

1990 • 381 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

MHC class l/β2-microglobulin complexes associate with TAP transporters before peptide binding

1994 • 356 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

1991 • 329 citations

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1985 • 322 citations

Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells

1984 • 318 citations

Interaction of MHC Class I Molecules with the Transporter Associated with Antigen Processing

1994 • 300 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

A sequential model for peptide binding and transport by the transporters associated with antigen processing

1994 • 290 citations

Ham-2 corrects the class I antigen-processing defect in RMA-S cells

1992 • 289 citations

Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner.

1993 • 266 citations

Allelic variants of the human putative peptide transporter involved in antigen processing.

1992 • 235 citations

Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

1975 • 217 citations

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1993 • 215 citations

Peptide size selection by the major histocompatibility complex-encoded peptide transporter.

1994 • 212 citations

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

1994 • 207 citations

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment.

1992 • 204 citations

Defective Presentation of Endogenous Antigen by a Cell Line Expressing Class I Molecules

1990 • 202 citations

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

1992 • 190 citations

Peptide Translocation by Variants of the Transporter Associated with Antigen Processing

1993 • 188 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

Human transporters associated with antigen processing possess a promiscuous peptide-binding site

1994 • 178 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2).

1994 • 150 citations

HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2.

1994 • 126 citations

Reconstitution by MHC-restricted peptides of HLA-A2 heavy chain with β2-microglobulin, in vitro

1991 • 104 citations

A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

1989 • 94 citations

An unstable beta 2-microglobulin: major histocompatibility complex class I heavy chain intermediate dissociates from calnexin and then is stabilized by binding peptide.

1994 • 93 citations

Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes

1994 • 92 citations

Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.

1994 • 43 citations