ErbB3 and ErbB2/neu mediate the effect of heregulin on acetylcholine receptor gene expression in muscle: differential expression at the endplate.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Synaptic structure and development: The neuromuscular junction

1993 • 846 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

1990 • 375 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains

1992 • 333 citations

Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

1989 • 317 citations

Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes

1986 • 312 citations

Neuregulins are concentrated at nerve-muscle synapses and activate ACh–receptor gene expression

1995 • 276 citations

Nicotinic acetylcholine receptors in vertebrate muscle: Properties, distribution and neural control

1985 • 229 citations

Acetylcholine receptor gene expression at the developing neuromuscular junction.

1995 • 215 citations

Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe.

1984 • 191 citations

Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes.

1986 • 184 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Activity regulates the levels of acetylcholine receptor alpha-subunit mRNA in cultured chicken myotubes.

1985 • 153 citations

HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor.

1989 • 144 citations

Regulation of muscle AChR α subunit gene expression by electrical activity: Involvement of protein kinase C and Ca 2+

1989 • 140 citations

Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.

1993 • 119 citations

Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21.

1993 • 119 citations

Skeletal muscle denervation activates acetylcholine receptor genes.

1989 • 108 citations

NDF/heregulin activates MAP kinase and p70/p85 S6 kinase during proliferation or differentiation of mammary epithelial cells.

1995 • 101 citations

Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.

1988 • 80 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein.

1993 • 77 citations

Functional activity of the two promoters of the myosin alkali light chain gene in primary muscle cell cultures: comparison with other muscle gene promoters and other culture systems

1988 • 74 citations

Neural regulation of gene expression by an acetylcholine receptor promoter in muscle of transgenic mice

1989 • 69 citations

Acetylcholine receptor alpha-subunit mRNA is increased by ascorbic acid in cloned L5 muscle cells: Northern blot analysis and in situ hybridization.

1989 • 51 citations

Depolarization-Transcription Signals in Skeletal Muscle Use Calcium Flux through L Channels, but Bypass the Sarcoplasmic Reticulum

1998 • 49 citations

Synapse-specific gene expression

1993 • 44 citations

Manipulation of medium conditions and differentiation in the rat myogenic cell line L6

1984 • 43 citations

Depolarization-transcription signals in skeletal muscle use calcium flux through L channels, but bypass the sarcoplasmic reticulum

1994 • 42 citations

Post‐transcriptional Compartmentalization of Acetylcholine Receptor Biosynthesis in the Subneural Domain of Muscle and Electrocyte Junctions

1993 • 39 citations

Phorbol esters inhibit the activity of the chicken acetylcholine receptor α‐subunit gene promoter

1991 • 24 citations

Regulation of an acetylcholine receptor LacZ transgene by muscle innervation

1992 • 20 citations

Tumor Promoter and Epidermal Growth Factor Stimulate Phosphorylation of the c-erbB-2 Gene Product in MKN-7 Human Adenocarcinoma Cells

1988 • 14 citations