Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Roles of PPARs in health and disease

2000 • 1,941 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

1997 • 614 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.

1995 • 536 citations

NF-kappa B and Sp1 regulate transcription of the human monocyte chemoattractant protein-1 gene.

1994 • 527 citations

Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.

1996 • 486 citations

Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

1989 • 481 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A

1997 • 379 citations

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

1997 • 314 citations

Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells.

1984 • 299 citations

Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.

1998 • 294 citations

Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential

1999 • 291 citations

Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells

1984 • 275 citations

Transcriptional Activation of Transforming Growth Factor β1 and Its Receptors by the Kruppel-like Factor Zf9/Core Promoter-binding Protein and Sp1

1998 • 250 citations

Molecular regulation of hepatic fibrogenesis

1998 • 249 citations

Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis

1998 • 242 citations

Signal transduction in hepatic stellate cells

1998 • 241 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells

1997 • 202 citations

Hepatic stellate cells and the regulation of liver inflammation

1999 • 187 citations

Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced byIn Vivo liver injury in the rat

1999 • 163 citations

The MKK6/p38 Stress Kinase Cascade Is Critical for Tumor Necrosis Factor-–Induced Expression of Monocyte-Chemoattractant Protein-1 in Endothelial Cells

1999 • 160 citations

Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production.

1990 • 150 citations

Activation of Peroxisome Proliferator-activated Receptor γ Bypasses the Function of the Retinoblastoma Protein in Adipocyte Differentiation

1999 • 143 citations

Tumor necrosis factor-alpha induces expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells

1993 • 116 citations

Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis

1997 • 112 citations

Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury*1

1995 • 112 citations

Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF

1993 • 108 citations

The functions of Myc proteins

1992 • 103 citations

Expression of monocyte chemotactic protein-1 precedes monocyte recruitment in a rat model of acute liver injury, and is modulated by vitamin E.

1999 • 98 citations

The MKK6/p38 Stress Kinase Cascade Is Critical for Tumor Necrosis Factor-–Induced Expression of Monocyte-Chemoattractant Protein-1 in Endothelial Cells

1999 • 84 citations

Simultaneous induction of stimulatory and inhibitory signals by PDGF

1997 • 82 citations

Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.

1996 • 76 citations

A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcription.

1998 • 73 citations

Troglitazone inhibits angiotensin II‐induced DNA synthesis and migration in vascular smooth muscle cells

1997 • 71 citations

A Complex Element Regulates IFN-γ-Stimulated Monocyte Chemoattractant Protein-1 Gene Transcription

1998 • 66 citations

All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially

1999 • 63 citations

A mutational analysis of phosphatidylinositol-3-kinase activation by human colony-stimulating factor-1 receptor

1991 • 56 citations

Retinoic acid suppression of c-fos gene inhibits expression of tumor necrosis factor-alpha-induced monocyte chemoattractant JE/MCP-1 in clonal osteoblastic MC3T3-E1 cells.

1994 • 46 citations

Knockout of α6β1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells

1998 • 44 citations

Integrin‐mediated stimulation of monocyte chemotactic protein‐1 expression

1997 • 28 citations