Insulin-Responsive Compartments Containing GLUT4 in 3T3-L1 and CHO Cells: Regulation by Amino Acid Concentrations

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

1995 • 3,159 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

1975 • 1,358 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane.

1980 • 1,066 citations

Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.

1980 • 1,042 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

Potential mechanism of insulin action on glucose transport in the isolated rat diaphragm. Apparent translocation of intracellular transport units to the plasma membrane.

1981 • 852 citations

New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes

2001 • 695 citations

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

1998 • 654 citations

CAP defines a second signalling pathway required for insulin-stimulated glucose transport

2000 • 646 citations

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1999 • 526 citations

Signaling Mechanisms That Regulate Glucose Transport

1999 • 525 citations

Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes.

1985 • 512 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity.

1981 • 456 citations

Molecular Basis of Insulin-stimulated GLUT4 Vesicle Trafficking

1999 • 417 citations

A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1

2000 • 415 citations

Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles.

1994 • 413 citations

Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat.

1991 • 398 citations

A glucose transport protein expressed predominately in insulin-responsive tissues.

1989 • 394 citations

Applications of retrovirus-mediated expression cloning.

1996 • 339 citations

Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.

1990 • 325 citations

Rapid Production of Retroviruses for Efficient Gene Delivery to Mammalian Cells Using 293 <scp>T</scp> Cell–Based Systems

1999 • 310 citations

Translocation of the glucose transporter (GLUT4) to the cell surface in permeabilized 3T3-L1 adipocytes: effects of ATP insulin, and GTP gamma S and localization of GLUT4 to clathrin lattices

1992 • 307 citations

Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles

1997 • 301 citations

Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.

1993 • 297 citations

Serine/Threonine Phosphorylation of IRS-1 Triggers Its Degradation

2001 • 296 citations

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.

1994 • 290 citations

Peroxisome Proliferator Activated Receptor γ, CCAAT/ Enhancer-binding Protein α, and Cell Cycle Status Regulate the Commitment to Adipocyte Differentiation

1997 • 272 citations

Differential sorting of two glucose transporters expressed in insulin-sensitive cells

1991 • 258 citations

Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.

1993 • 252 citations

Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes.

1980 • 252 citations

Regulation of Insulin-stimulated GLUT4 Translocation by Munc18c in 3T3L1 Adipocytes

1998 • 237 citations

Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes.

1990 • 236 citations

Effects of insulin on steady state kinetics of GLUT4 subcellular distribution in rat adipocytes. Evidence of constitutive GLUT4 recycling.

1992 • 225 citations

Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells

1998 • 221 citations

GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay

1998 • 220 citations

Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.

1999 • 203 citations

Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways

1999 • 197 citations

Overexpression of Catalytic Subunit p110α of Phosphatidylinositol 3-Kinase Increases Glucose Transport Activity with Translocation of Glucose Transporters in 3T3-L1 Adipocytes

1996 • 194 citations

Mammalian TOR Controls One of Two Kinase Pathways Acting upon nPKCδ and nPKCε

1999 • 182 citations

Two Compartments for Insulin-Stimulated Exocytosis in 3t3-L1 Adipocytes Defined by Endogenous Acrp30 and Glut4

1999 • 175 citations

Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools

1994 • 164 citations

Immunoelectron microscopic demonstration of insulin-stimulated translocation of glucose transporters to the plasma membrane of isolated rat adipocytes and masking of the carboxyl-terminal epitope of intracellular GLUT4.

1991 • 162 citations

Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents.

1987 • 158 citations

Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain

1993 • 156 citations

Characterization of the Insulin-regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes

1996 • 152 citations

Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 149 citations

Compartment ablation analysis of the insulin-responsive glucose transporter (GLUT4) in 3T3-L1 adipocytes

1996 • 147 citations

Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type.

1991 • 141 citations

Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine

1992 • 136 citations

GLUT4Gene Regulation and Manipulation

1999 • 133 citations

Expression of a Dominant Interfering Dynamin Mutant in 3T3L1 Adipocytes Inhibits GLUT4 Endocytosis without Affecting Insulin Signaling

1998 • 115 citations

Demonstration of insulin-responsive trafficking of GLUT4 and vpTR in fibroblasts

2000 • 113 citations

Characterization of Insulin-Responsive GLUT4 Storage Vesicles Isolated from 3T3-L1 Adipocytes

2000 • 113 citations

Insulin Action on GLUT4 Traffic Visualized in Single 3T3-L1 Adipocytes by Using Ultra-fast Microscopy

2001 • 107 citations

Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

1999 • 107 citations

Insulin-Stimulated Glucose Uptake Involves the Transition of Glucose Transporters to a Caveolae-Rich Fraction within the Plasma Membrane: Implications for Type II Diabetes

1996 • 102 citations

GLUT4 – At the Cross Roads Between Membrane Trafficking and Signal Transduction

2001 • 102 citations

Immunocytochemical Evidence that GLUT4 Resides in a Specialized Translocation Post-endosomal VAMP2-positive Compartment in Rat Adipose Cells in the Absence of Insulin

1997 • 101 citations

The Prolactin Receptor and Severely Truncated Erythropoietin Receptors Support Differentiation of Erythroid Progenitors

1997 • 101 citations

Identification of Wortmannin-sensitive Targets in 3T3-L1 Adipocytes

1999 • 99 citations

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1993 • 98 citations

Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4.

1995 • 97 citations

Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts.

1992 • 95 citations

Effects of insulin on intracellular GLUT4 vesicles in adipocytes: evidence for a secretory mode of regulation

2000 • 94 citations

Insulin-responsive Aminopeptidase Trafficking in 3T3-L1 Adipocytes

2000 • 91 citations

Tyrosine kinase-deficient mutant human insulin receptors (Met1153--&gt;Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.

1994 • 91 citations

Development of an intracellular pool of glucose transporters in 3T3-L1 cells.

1992 • 88 citations

The glucose transporter GLUT4 and the aminopeptidase vp165 colocalise in tubulo-vesicular elements in adipocytes and cardiomyocytes

1997 • 86 citations

A distinct class of intracellular storage vesicles, identified by expression of the glucose transporter GLUT4.

1994 • 85 citations

Domains responsible for the differential targeting of glucose transporter isoforms.

1992 • 82 citations

Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.

1993 • 81 citations

Characterization of the Insulin-regulated Endocytic Recycling Mechanism in 3T3-L1 Adipocytes Using a Novel Reporter Molecule

2000 • 80 citations

GLUT4 vesicle dynamics in living 3T3 L1 adipocytes visualized with green-fluorescent protein

1997 • 79 citations

Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes.

1995 • 79 citations

Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-L1 adipocytes.

1986 • 76 citations

Identification of the carboxy terminus as important for the isoform-specific subcellular targeting of glucose transporter proteins.

1993 • 75 citations

Insulin Recruits GLUT4 from Specialized VAMP2-carrying Vesicles as well as from the Dynamic Endosomal/Trans-Golgi Network in Rat Adipocytes.

2000 • 74 citations

Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment

1997 • 72 citations

The Formation of an Insulin-responsive Vesicular Cargo Compartment Is an Early Event in 3T3-L1 Adipocyte Differentiation

1999 • 70 citations

Determination of the rates of appearance and loss of glucose transporters at the cell surface of rat adipose cells

1991 • 68 citations

Multiple endosomal recycling pathways in rat adipose cells

1998 • 65 citations

Trafficking of glucose transporters in 3T3-L1 cells. Inhibition of trafficking by phenylarsine oxide implicates a slow dissociation of transporters from trafficking proteins

1992 • 62 citations

Kinetic analysis of glucose transporter trafficking in fibroblasts and adipocytes

1995 • 61 citations

GLUT4 and Transferrin Receptor Are Differentially Sorted Along the Endocytic Pathway in CHO Cells

1998 • 60 citations

Trafficking Kinetics of the Insulin-Regulated Membrane Aminopeptidase in 3T3-L1 Adipocytes

1997 • 54 citations

Vp165 and GLUT4 share similar vesicle pools along their trafficking pathways in rat adipose cells

1997 • 54 citations

Targeting of the "insulin-responsive" glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 53 citations

Insulin Regulation and Selective Segregation with Glucose Transporter-4 of the Membrane Aminopeptidase vp165 in Rat Skeletal Muscle Cells¹

1997 • 52 citations

Dynamics of insulin‐stimulated translocation of GLUT4 in single living cells visualised using green fluorescent protein

1996 • 52 citations

Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin

2000 • 50 citations

Functional studies in 3T3L1 cells support a role for SNARE proteins in insulin stimulation of GLUT4 translocation

1997 • 49 citations

Morphological effects of wortmannin on the endosomal system and GLUT4-containing compartments in rat adipose cells

1997 • 49 citations

Efficient retroviral-mediated gene transfer into human B lymphoblastoid cells expressing mouse ecotropic viral receptor

1992 • 48 citations

Two glucose transporter isoforms are sorted differentially and are expressed in distinct cellular compartments

1992 • 48 citations

Identification of an Insulin-responsive, Slow Endocytic Recycling Mechanism in Chinese Hamster Ovary Cells

1998 • 48 citations

Insulin Regulation of Protein Traffic in Rat Adipose Cells

1999 • 47 citations

Analysis of Amino and Carboxy Terminal GLUT-4 Targeting Motifs in 3T3-L1 Adipocytes Using an Endosomal Ablation Technique

1999 • 37 citations

FRAP-Dependent Serine Phosphorylation of IRS-1 Inhibits IRS-1 Tyrosine Phosphorylation

2001 • 37 citations

Increased intracellular sequestration of the insulin-regulated aminopeptidase upon differentiation of 3T3-L1 cells

1998 • 37 citations

Subcellular distribution and activity of glucose transporter isoforms GLUT1 and GLUT4 transiently expressed in COS-7 cells

1992 • 33 citations

Separation and Partial Characterization of Three Distinct Intracellular GLUT4 Compartments in Rat Adipocytes

1999 • 33 citations

Modulation of GLUT4 and GLUT1 Recycling by Insulin in Rat Adipocytes: Kinetic Analysis Based on the Involvement of Multiple Intracellular Compartments

2000 • 31 citations

A Phosphatidylinositol 3-Kinase/p70 Ribosomal S6 Protein Kinase Pathway Is Required for the Regulation by Insulin of the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase Gene Expression in Human Muscle Cells

1999 • 29 citations

Overexpression of the glucose transporter GLUT4 in adipose cells interferes with insulin‐stimulated translocation

1999 • 29 citations

Roles of insulin, guanosine 5′-[γ-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation

1996 • 25 citations

Subcellular trafficking kinetics of GLU4 mutated at the N- and C-terminal

1996 • 22 citations

Possible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4

1995 • 20 citations

Expression of human β3-adrenergic receptor induces adipocyte-like features in CHO/K1 fibroblasts

1999 • 17 citations

Possible role for gp160 in constitutive but not insulin-stimulated GLUT4 trafficking: dissociation of gp160 and GLUT4 localization

1998 • 10 citations

Subcellular trafficking of GLUT4 in insulin target cells

1996 • 9 citations