Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia

Tensional homeostasis and the malignant phenotype

2005 • 3,655 citations

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

2005 • 1,225 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Rho family proteins: coordinating cell responses

2001 • 763 citations

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

2002 • 763 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Cdc42 - the centre of polarity

2004 • 725 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

1991 • 659 citations

Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.

1996 • 523 citations

ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix

2003 • 510 citations

Integrin signaling to the actin cytoskeleton

2003 • 497 citations

Rho and Rac but not Cdc42 regulate endothelial cell permeability

2001 • 462 citations

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK

2000 • 454 citations

A Rac switch regulates random versus directionally persistent cell migration

2005 • 449 citations

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

2001 • 444 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling

2003 • 374 citations

Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

2001 • 261 citations

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases

2002 • 247 citations

E-cadherin is a survival factor for the lactating mouse mammary gland

2002 • 244 citations

Stem Cell Depletion Through Epidermal Deletion of Rac1

2005 • 242 citations

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation

2005 • 215 citations

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

2003 • 201 citations

RAC1 Regulates Adherens Junctions through Endocytosis of E-Cadherin

2001 • 198 citations

Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors

2003 • 187 citations

Dual Signaling Role of the Protein Tyrosine Phosphatase SHP-2 in Regulating Expression of Acute-Phase Plasma Proteins by Interleukin-6 Cytokine Receptors in Hepatic Cells

1999 • 170 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

Molecular Characterization of Specific Interactions between SHP-2 Phosphatase and JAK Tyrosine Kinases

1997 • 140 citations

Mutation of the SHP-2 Binding Site in Growth Hormone (GH) Receptor Prolongs GH-Promoted Tyrosyl Phosphorylation of GH Receptor, JAK2, and STAT5B

2000 • 131 citations

Prolactin receptor signal transduction

2001 • 121 citations

Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo

1991 • 120 citations

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases

1998 • 97 citations

Dominant Negative Variants of the SHP-2 Tyrosine Phosphatase Inhibit Prolactin Activation of Jak2 (Janus Kinase 2) and Induction of Stat5 (Signal Transducer and Activator of Transcription 5)-Dependent Transcription

1998 • 58 citations

The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis

2003 • 55 citations

A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation

2003 • 54 citations

The first CH domain of affixin activates Cdc42 and Rac1 through αPIX, a Cdc42/Rac1‐specific guanine nucleotide exchanging factor

2004 • 52 citations

Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands

2003 • 51 citations

Activation and Association of the Tec Tyrosine Kinase with the Human Prolactin Receptor: Mapping of a Tec/Vav1-Receptor Binding Site

2001 • 43 citations

Perturbation of β1-Integrin Function in Involuting Mammary Gland Results in Premature Dedifferentiation of Secretory Epithelial Cells

2002 • 41 citations

STAT5a Activation Mediates the Epithelial to Mesenchymal Transition Induced by Oncogenic RhoA.

2003 • 35 citations

Adenoviral-mediated gene transfer in two-dimensional and three-dimensional cultures of mammary epithelial cells

2002 • 13 citations