Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

2005 • 2,658 citations

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

1998 • 1,224 citations

Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

2005 • 1,026 citations

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

2001 • 852 citations

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

2000 • 799 citations

Cell migration in tumors

2005 • 722 citations

Target Protease Specificity of the Viral Serpin CrmA

1997 • 517 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Regulating cell migration: calpains make the cut

2005 • 476 citations

Electrical wound-healing assay for cells in vitro

2004 • 408 citations

Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles

2004 • 372 citations

Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies

2000 • 332 citations

Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

2000 • 326 citations

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

2000 • 311 citations

CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

2004 • 287 citations

Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway

2000 • 272 citations

Potentiation of neuroblastoma metastasis by loss of caspase-8

2006 • 270 citations

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis

1998 • 270 citations

Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy.

2003 • 269 citations

Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation

2004 • 265 citations

Cross-talk between Calpain and Caspase Proteolytic Systems During Neuronal Apoptosis

2003 • 251 citations

Reduced Cell Migration and Disruption of the Actin Cytoskeleton in Calpain-deficient Embryonic Fibroblasts

2001 • 250 citations

Activation of caspases-8 and -10 by FLIPL

2004 • 240 citations

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

2004 • 238 citations

MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

1998 • 236 citations

Vital functions for lethal caspases

2005 • 228 citations

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

2004 • 225 citations

The death effector domain protein family: regulators of cellular homeostasis

2003 • 222 citations

Interaction of calpastatin with calpain: a review

2004 • 219 citations

D4-GDI, a Substrate of CPP32, Is Proteolyzed during Fas-induced Apoptosis

1996 • 216 citations

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

1998 • 202 citations

A Novel Role for FAK as a Protease-Targeting Adaptor Protein

2003 • 194 citations

A Role for Drosophila IAP1-Mediated Caspase Inhibition in Rac-Dependent Cell Migration

2004 • 193 citations

Chemosensitivity of solid tumor cellsin vitro is related to activation of the CD95 system

1998 • 170 citations

The Role of Calpain in the Proteolytic Cleavage of E-cadherin in Prostate and Mammary Epithelial Cells

2003 • 169 citations

The Caspase-8 Modulator c-FLIP

2005 • 167 citations

Identification of the Cytolinker Plectin as a Major Early In Vivo Substrate for Caspase 8 during CD95- and Tumor Necrosis Factor Receptor-Mediated Apoptosis

2000 • 157 citations

Isoform specific function of calpain 2 in regulating membrane protrusion

2004 • 133 citations

Dephosphorylation of Focal Adhesion Kinase (FAK) and Loss of Focal Contacts Precede Caspase-mediated Cleavage of FAK during Apoptosis in Renal Epithelial Cells

1999 • 127 citations

MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts

2003 • 125 citations

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

1998 • 122 citations

Calpain-2 as a target for limiting prostate cancer invasion.

2003 • 111 citations

Apoptosis-independent functions of killer caspases

2002 • 109 citations

Caspase‐dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF‐α‐mediated bovine pulmonary endothelial cell apoptosis

2003 • 96 citations

Fas and Fas ligand interactions in malignant disease.

2000 • 95 citations

Caspases Cleave the Amino-Terminal Calpain Inhibitory Unit of Calpastatin during Apoptosis in Human Jurkat T Cells

2000 • 77 citations

Cdc42 Is a Substrate for Caspases and Influences Fas-induced Apoptosis

2001 • 72 citations

Cleavage of β-Catenin by Calpain in Prostate and Mammary Tumor Cells

2004 • 71 citations

Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis

1999 • 67 citations

Expression of calpain I messenger RNA in human renal cell carcinoma: Correlation with lymph node metastasis and histological type

1999 • 66 citations

Calpain Activity Is Generally Elevated during Transformation but Has Oncogene-Specific Biological Functions

2004 • 66 citations

Caspase 3-Mediated Inactivation of Rac GTPases Promotes Drug-Induced Apoptosis in Human Lymphoma Cells

2003 • 43 citations

Activation of m-Calpain Is Required for Chromosome Alignment on the Metaphase Plate during Mitosis

2004 • 40 citations

SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes

2005 • 40 citations

Monitoring Caspase Activity in Living Cells Using Fluorescent Proteins and Flow Cytometry

2004 • 40 citations

Gα11 Induces Caspase-mediated Proteolytic Activation of Rho-associated Kinase, ROCK-I, in HeLa Cells

2001 • 34 citations

Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis.

2003 • 31 citations

Motility is rate-limiting for invasion of bladder carcinoma cell lines

2002 • 29 citations