Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment

Reactivity of a monoclonal antibody with human ovarian carcinoma.

1981 • 1,648 citations

Structural requirements for the growth factor activity of the amino-terminal domain of urokinase.

1992 • 236 citations

An amino-terminal fragment of urokinase isolated from a prostate cancer cell line (PC-3) is mitogenic for osteoblast-like cells

1990 • 177 citations

Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.

1992 • 168 citations

Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.

1997 • 149 citations

Proliferation of a human epidermal tumor cell line stimulated by urokinase

1987 • 132 citations

Secretion of extracellular matrix‐degrading proteinases is increased in epithelial ovarian carcinoma

1994 • 120 citations

Prospective on ovarian cancer: Why prevent?

1995 • 111 citations

Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the αA2β1 integrin

1996 • 108 citations

Hepsin, a Putative Membrane-associated Serine Protease, Activates Human Factor VII and Initiates a Pathway of Blood Coagulation on the Cell Surface Leading to Thrombin Formation

1995 • 108 citations

The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.

1998 • 88 citations

The significance of urokinase-type plasminogen activator, its inhibitors, and its receptor in ascites of patients with epithelial ovarian cancer

1995 • 79 citations

Urokinase-Type and Tissue-Type Plasminogen Activators as Growth Factors of Human Fibroblasts

1994 • 78 citations

The Two Human Trypsinogens. Inhibiton Spectra of the Two Human Trypsins Derived from Their Purified Zymogens

1975 • 75 citations

Membrane-type matrix metalloproteinase expression and matrix metalloproteinase-2 activation in primary human ovarian epithelial carcinoma cells.

1996 • 73 citations

The matrix metalloproteinase pump-1 catalyzes formation of low molecular weight (pro)urokinase in cultures of normal human kidney cells.

1992 • 69 citations

Cyst fluid of ovarian cancer patients contains high concentrations of trypsinogen-2.

1990 • 67 citations

Activation with plasmin of two-chain urokinase-type plasminogen activator derived from single-chain urokinase-type plasminogen activator by treatment with thrombin

1987 • 61 citations

The plasminogen‐activation system in ovarian tumors

1993 • 53 citations

Coordinate expression of urinary-type plasminogen activator and its receptor accompanies malignant transformation of the ovarian surface epithelium

1994 • 37 citations

An examination of the inhibitory mechanism of serpins by analysing the interaction of trypsin and chymotrypsin with α2-antiplasmin

1993 • 33 citations

Mitogenic effect of urokinase on malignant and unaffected adjacent human renal cells

1988 • 30 citations