Inhibition of Tumor Invasion by Genomic Down-regulation of Matriptase through Suppression of Activation of Receptor-bound Pro-urokinase

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

The plasminogen activation system in tumor growth, invasion, and metastasis

2000 • 930 citations

Molecular insights into cancer invasion: strategies for prevention and intervention.

1995 • 500 citations

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

2000 • 432 citations

Activation of Hepatocyte Growth Factor and Urokinase/Plasminogen Activator by Matriptase, an Epithelial Membrane Serine Protease

2000 • 394 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

1986 • 343 citations

Type II Transmembrane Serine Proteases

2001 • 341 citations

Plasminogen Activators and Matrix Metalloproteinases in Angiogenesis

1996 • 341 citations

Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue

1999 • 254 citations

Purification and Characterization of a Complex Containing Matriptase and a Kunitz-type Serine Protease Inhibitor from Human Milk

1999 • 243 citations

Molecular Cloning of cDNA for Matriptase, a Matrix-degrading Serine Protease with Trypsin-like Activity

1999 • 223 citations

Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review).

1998 • 216 citations

Plasminogen activator inhibitor type‐1 : reactive center and amino‐terminal heterogeneity determined by protein and cDNA sequencing

1986 • 207 citations

Matriptase and HAI-1 Are Expressed by Normal and Malignant Epithelial Cells in Vitro and in Vivo

2001 • 188 citations

Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.

2002 • 186 citations

The Dietary Pigment Curcumin Reduces Endothelial Tissue Factor Gene Expression by Inhibiting Binding of AP-1 to the DNA and Activation of NF-κB

1997 • 165 citations

TGF-?-induced invasiveness of pancreatic cancer cells is mediated by matrix metalloproteinase-2 and the urokinase plasminogen activator system

2001 • 145 citations

Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains

1999 • 138 citations

Urokinase-type plasminogen activator: a potent marker of metastatic potential in human cancers

2002 • 104 citations

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor

1995 • 101 citations

Ovarian Tumor Cells Express a Transmembrane Serine Protease: A Potential Candidate for Early Diagnosis and Therapeutic Intervention

2001 • 82 citations

N-terminal Processing Is Essential for Release of Epithin, a Mouse Type II Membrane Serine Protease

2001 • 81 citations

Suppression of Urokinase Expression and Invasiveness by Urinary Trypsin Inhibitor Is Mediated through Inhibition of Protein Kinase C- and MEK/ERK/c-Jun-dependent Signaling Pathways

2001 • 72 citations

Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours

2001 • 68 citations

A bifunctional hybrid molecule of the amino‐terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasis

1998 • 62 citations

Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin

2003 • 61 citations

Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis

2003 • 60 citations

A Kunitz-type Protease Inhibitor, Bikunin, Inhibits Ovarian Cancer Cell Invasion by Blocking the Calcium-dependent Transforming Growth Factor-β1 Signaling Cascade

2003 • 58 citations

Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal‐regulated kinase‐dependent cascade

2002 • 45 citations

Structural analysis of the interaction between urokinase-type plasminogen activator and its receptor: a potential target for anti-invasive cancer therapy

2002 • 44 citations

Identity of Urinary Trypsin Inhibitor-binding Protein to Link Protein

2000 • 41 citations

Stable transfection of urokinase-type plasminogen activator antisense construct modulates invasion of human glioblastoma cells.

2001 • 37 citations

Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins

2001 • 31 citations

Characterization of Binding Properties of Urinary Trypsin Inhibitor to Cell-associated Binding Sites on Human Chondrosarcoma Cell Line HCS-2/8

2001 • 29 citations

Kunitz-type Protease Inhibitor Bikunin Disrupts Phorbol Ester-induced Oligomerization of CD44 Variant Isoforms Containing Epitope v9 and Subsequently Suppresses Expression of Urokinase-type Plasminogen Activator in Human Chondrosarcoma Cells

2002 • 29 citations

Identification and characterization of the cell-associated binding protein for urinary trypsin inhibitor

1998 • 28 citations

Antisense inhibition of urokinase: Effect on malignancy in a human osteosarcoma cell line

1998 • 25 citations

Reduced bikunin gene expression as a factor of poor prognosis in ovarian carcinoma

2003 • 23 citations

Suppression of urokinase expression and tumor metastasis by bikunin overexpression [mini-review].

2001 • 18 citations

Invasion by esophageal cancer cells: functional contribution of the urokinase plasminogen activation system, and inhibition by antisense oligonucleotides to urokinase or urokinase receptor.

1999 • 13 citations

Urokinase plasminogen activator is necessary but not sufficient for prostate cancer cell invasion.

1995 • 9 citations