Antisense inhibition of urokinase reduces spread of human ovarian cancer in mice

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 • 606 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Prevention of metastasis by inhibition of the urokinase receptor.

1993 • 387 citations

Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

1993 • 367 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Surface receptors for urokinase plasminogen activator

1988 • 222 citations

Ablation of Transplanted HTLV-I Tax-Transformed Tumors in Mice by Antisense Inhibition of NF-κB

1992 • 207 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy.

1994 • 171 citations

Immunological identity of urokinase and ovarian carcinoma plasminogen activator released in tissue culture

1976 • 161 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

Urokinase (uPA) and PAI-1 Predict Survival in Advanced Ovarian Cancer Patients (FIGO III) after Radical Surgery and Platinum-Based Chemotherapy

1994 • 140 citations

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor.

1993 • 108 citations

Recombinant soluble urokinase receptor as a scavenger for urokinase‐type plasminogen activator (uPA)

1994 • 101 citations

Interaction of urokinase‐type plasminogenactivator (u‐PA) with its cellular receptor (u‐PAR) induces phosphorylation on tyrosine of a 38 kDa protein

1993 • 100 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes.

1990 • 99 citations

Urokinase-type and tissue-type plasminogen activators are essential for in vitro invasion of human melanoma cells

1991 • 85 citations

Morphological, immunohistochemical and biochemical characterization of 6 newly established human ovarian carcinoma cell lines

1992 • 82 citations

Inhibition of the Metastasis of Lewis Lung Carcinoma by Antibody Against Urokinase-Type Plasminogen Activator in the Experimental and Spontaneous Metastasis Model

1994 • 61 citations

Generation of cell surface-bound plasmin by cell-associated urokinase-type or secreted tissue-type plasminogen activator: A key event in melanoma cell invasiveness in vitro

1992 • 49 citations

Fibrin-fibronectin compounds in human ovarian tumor ascites and their possible relation to the tumor stroma.

1988 • 44 citations

Growth stimulation of human epidermal cells by urokinase is restricted to the intact active enzyme

1989 • 42 citations

Saturation of tumour cell surface receptors for urokinase-type plasminogen activator by amino-terminal fragment and subsequent effect on reconstituted basement membranes invasion

1993 • 42 citations

Crosslinked fibrin derivatives and fibronectin in ascitic fluid from patients with ovarian cancer compared to ascitic fluid in liver cirrhosis

1984 • 32 citations

Role of plasmin in the degradation of the stroma-derived fibrin in human ovarian carcinoma

1990 • 29 citations

EXPRESSION OF UROKINASE-TYPE PLASMINOGEN-ACTIVATOR (UPA) AND ITS RECEPTOR (UPAR) IN HUMAN OVARIAN-CANCER CELLS AND IN-VITRO INVASION CAPACITY

1994 • 9 citations

UROKINASE-TYPE PLASMINOGEN-ACTIVATOR (UPA), A PROTEASE WITH CYTOKINE-LIKE ACTIVITY IN HUMAN HL-60 LEUKEMIC-CELL LINE

1993 • 7 citations

The urokinase/urokinase receptor system A new target for cancer therapy?

1994 • 3 citations