Cytotoxic Cell Granule-Mediated Apoptosis

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis

2000 • 393 citations

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

1996 • 368 citations

Initiation of Apoptosis by Granzyme B Requires Direct Cleavage of Bid, but Not Direct Granzyme B–Mediated Caspase Activation

2000 • 361 citations

β-Chemokines are released from HIV-1-specific cytolytic T-cell granules complexed to proteoglycans

1998 • 334 citations

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

1986 • 316 citations

Granzyme B Directly and Efficiently Cleaves Several Downstream Caspase Substrates: Implications for CTL-Induced Apoptosis

1998 • 316 citations

A Novel Ligand for CD44 Is Serglycin, a Hematopoietic Cell Lineage-specific Proteoglycan

1995 • 272 citations

Cytosolic Delivery of Granzyme B by Bacterial Toxins: Evidence that Endosomal Disruption, in Addition to Transmembrane Pore Formation, Is an Important Function of Perforin

1999 • 214 citations

Entry and Trafficking of Granzyme B in Target Cells During Granzyme B-Perforin–Mediated Apoptosis

1998 • 210 citations

Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain

1997 • 195 citations

Granzyme B Mimics Apical Caspases

1998 • 171 citations

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes.

1997 • 161 citations

Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.

1985 • 149 citations

Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly proteases

1998 • 144 citations

Packaging of Proteases and Proteoglycans in the Granules of Mast Cells and Other Hematopoietic Cells

1995 • 131 citations

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

2000 • 104 citations

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

1996 • 102 citations

A novel method for measuring CTL and NK cell-mediated cytotoxicity using annexin V and two-color flow cytometry

1999 • 92 citations

Rapid Purification of Cationic Granule Proteases: Application to Human Granzymes

1993 • 66 citations

Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody.

1992 • 60 citations

Apoptosis Induced by Granzyme B-Glycosaminoglycan Complexes: Implications for Granule-Mediated Apoptosis In Vivo

1999 • 54 citations

Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans

1987 • 46 citations

Necrosis and apoptosis associated with distinct Ca2+ response patterns in target cells attacked by human natural killer cells.

1996 • 41 citations

Human Perforin: Rapid Enrichment by Immobilized Metal Affinity Chromatography (IMAC) for Whole Cell Cytotoxicity Assays

1996 • 39 citations

Serglycin secreted by leukocytes is efficiently eliminated from the circulation by sinusoidal scavenger endothelial cells in the liver

2000 • 39 citations

Structure and Function of the Family of Proteoglycans That Reside in the Secretory Granules of Natural Killer Cells and Other Effector Cells of the Immune Response

1988 • 37 citations

Transients of perforin pore formation observed by fluorescence microscopic single channel recording.

1990 • 34 citations

Reduction in Mitochondrial Membrane Potential Is an Early Event in Fas-Independent CTL-Mediated Apoptosis

1999 • 33 citations

Function of Granule Perform and Esterases in T Cell‐Mediated Reactions

1988 • 28 citations

Cell Death-Associated Translocation of Plasma Membrane Components Induced by CTL

2000 • 23 citations

Monoclonal antibodies detecting discrete epitopes of human perforin

1990 • 9 citations

Separation and purification of high molecular weight glycoproteins using agarose gel electrophoresis.

1992 • 4 citations