Modulation of E2F Complexes during G0 to S Phase Transition in Human Primary B-lymphocytes

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

The regulation of E2F by pRB-family proteins

1998 • 2,297 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

1991 • 374 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry

1996 • 327 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.

1996 • 251 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1995 • 250 citations

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

1993 • 235 citations

Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain.

1993 • 235 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G₀ Cell State From a G₁ Cell State

1996 • 222 citations

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

1998 • 217 citations

DP and E2F proteins: coordinating transcription with cell cycle progression

1994 • 205 citations

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

1998 • 190 citations

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins

1996 • 176 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

1995 • 165 citations

Cell heterogeneity during the cell cycle

1982 • 157 citations

Cell Cycle Regulation of E2F Site Occupation in Vivo

1996 • 152 citations

Biological Function of the Retinoblastoma Protein Requires Distinct Domains for Hyperphosphorylation and Transcription Factor Binding

1992 • 143 citations

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

1995 • 129 citations

HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes.

1994 • 124 citations

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

1992 • 115 citations

Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle

1996 • 107 citations

Transcriptional repression by the Rb-related protein p107.

1993 • 102 citations

A closer look at E2F

1992 • 95 citations

DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.

1994 • 90 citations

Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity.

1995 • 74 citations

p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB

1998 • 73 citations

Cell-cycle regulation of human B-myb transcription

1995 • 72 citations

Drastically increased expression of MYC and FOS protooncogenes during in vitro differentiation of chronic lymphocytic leukemia cells.

1987 • 68 citations

p130, p107, and pRb Are Differentially Regulated in Proliferating Cells and during Cell Cycle Arrest by α-Interferon

1998 • 52 citations

Characterization of Cell Cycle Status and E2F Complexes in Mobilized CD34+ Cells Before and After Cytokine Stimulation

1997 • 50 citations

DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.

1996 • 49 citations

Proliferation and differentiation of human CD5⁺ and CD5⁻ B cell subsets activated through their antigen receptors or CD40 antigens

1992 • 48 citations

Regulation of the Product of a Possible Human Cell Cycle Control Gene CDC2Hs in B-cells by α-Interferon and Phorbol Ester

1989 • 30 citations

Modulation of E2F Activity via Signaling through Surface IgM and CD40 Receptors in WEHI-231 B Lymphoma Cells

1998 • 26 citations

Phorbol ester induction of early response gene expression in lymphocytic leukemia and normal human B-cells

1993 • 22 citations

The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F‐4, DP‐1 and p130

1997 • 19 citations

Regulation and Activity of the Retinoblastoma Protein Family in Growth Factor-Deprived and TGFβ-Treated Keratinocytes

1996 • 9 citations