Hyperosmotic Stress as a Stimulant for Proinflammatory Cytokine Production

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

lnterleukin-8 and Related Chemotactic Cytokines—CXC and CC Chemokines

1993 • 1,650 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

1987 • 545 citations

Osmotic regulation of cytokine synthesis in vitro.

1995 • 282 citations

Recombinant C5a stimulates transcription rather than translation of interleukin-1 (IL-1) and tumor necrosis factor: translational signal provided by lipopolysaccharide or IL-1 itself

1990 • 232 citations

Dissociation between interleukin-1 beta mRNA and protein synthesis in human peripheral blood mononuclear cells.

1990 • 225 citations

Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement

1990 • 197 citations

Concentrations of Immunoreactive Human Tumor Necrosis Factor Alpha Produced by Human Mononuclear Cells In Vitro

1988 • 172 citations

Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

1993 • 123 citations

Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles.

1994 • 76 citations

Molecular cloning of human p38 MAP kinase

1995 • 69 citations

A method for removing interleukin-1- and tumor necrosis factor-inducing substances from bacterial cultures by ultrafiltration with polysulfone

1989 • 62 citations

A radioimmunoassay for human interleukin-1 alpha: measurement of IL-1 alpha produced in vitro by human blood mononuclear cells stimulated with endotoxin.

1988 • 55 citations

Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver.

1994 • 51 citations

Coagulation of Whole Blood Stimulates Interleukin-1 Gene Expression

1995 • 41 citations

High-resolution analysis ofgroαmRNA poly(A) shortening: regulation by interleukin-1β

1993 • 30 citations

Interleukin-1α expression is inducible by cholinergic stimulation in the rat adrenal gland

1992 • 29 citations