Expressions ofPDGF receptor alpha, c‐KitandFlk1genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

1995 • 1,421 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

In vitro differentiation of embryonic stem cells

1995 • 965 citations

A Requirement for Flk1 in Primitive and Definitive Hematopoiesis and Vasculogenesis

1997 • 938 citations

Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture

1994 • 891 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

1986 • 761 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors

1993 • 707 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

1995 • 596 citations

Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope

1993 • 577 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.

1991 • 479 citations

Evidence for Involvement of Activin A and Bone Morphogenetic Protein 4 in Mammalian Mesoderm and Hematopoietic Development

1995 • 464 citations

Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis

1996 • 426 citations

Ligand-dependent development of the endothelial and hemopoietic lineages from embryonic mesodermal cells expressing vascular endothelial growth factor receptor 2

1997 • 412 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

Platelet endothelial cell adhesion molecule-1 (PECAM-1 / CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development

1994 • 301 citations

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci

1991 • 292 citations

Coordinate expression of vascular endothelial growth factor receptor‐1 (fit‐1) and its ligand suggests a paracrine regulation of murine vascular development

1995 • 288 citations

A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells

1992 • 259 citations

Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos

1996 • 247 citations

Regulation and role of PDGF receptor a-subunit expression during embryogenesis

1992 • 239 citations

Vascular endothelial cell lineage-specific promoter in transgenic mice

1995 • 196 citations

Developmental expression of the α receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation

1992 • 191 citations

Hematopoiesis: how does it happen?

1995 • 169 citations

The angiogenic potentials of the cephalic mesoderm and the origin of brain and head blood vessels

1995 • 144 citations

The mouse W/c-kit locus.

1990 • 87 citations

In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand.

1992 • 69 citations

Close physical linkage of the FLT1 and FLT3 genes on chromosome 13 in man and chromosome 5 in mouse.

1993 • 67 citations

Postimplantation development in the mouse

1992 • 67 citations

Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III.

1992 • 66 citations

In vitro analysis of epiblast tissue potency for hematopoietic cell differentiation

1996 • 59 citations

[31] Whole-mount immunohistochemistry

1993 • 58 citations

Structural analysis of chromosomal rearrangements associated with the developmental mutations Ph, W19H, and Rw on mouse chromosome 5.

1994 • 44 citations

A 1.8-Mb YAC contig spanning three members of the receptor tyrosine kinase gene family (Pdgfra, Kit, and Flk1) on mouse chromosome 5

1995 • 23 citations

Clonal analysis of cell lineages

1990 • 21 citations

Murine Endothelial Cell Line Cells, F‐2: Interaction with Leukocytes and Cytokines Production

1993 • 10 citations

[11] Histogenetic potency of embryonic tissues in ectopic sites

1993 • 10 citations