Drug-Induced Long QT Syndrome

A Comparison of Rate Control and Rhythm Control in Patients with Atrial Fibrillation

2002 • 4,278 citations

An analysis of the time-relations of electrocardiograms

1920 • 3,889 citations

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1996 • 1,746 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death

1957 • 1,593 citations

CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism

2004 • 1,530 citations

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

1990 • 1,467 citations

MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia

1999 • 1,344 citations

Genome-wide association study identifies eight loci associated with blood pressure

2009 • 1,190 citations

Dofetilide in Patients with Congestive Heart Failure and Left Ventricular Dysfunction

1999 • 1,013 citations

Die Systolendauer im Elektrokardiogramm bei normalen Menschen und bei Herzkranken

1920 • 981 citations

Mutations in Kir2.1 Cause the Developmental and Episodic Electrical Phenotypes of Andersen's Syndrome

2001 • 973 citations

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

2003 • 958 citations

A structural basis for drug-induced long QT syndrome

2000 • 911 citations

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

1993 • 843 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

Low Penetrance in the Long-QT Syndrome

1999 • 817 citations

Cellular Basis for the Electrocardiographic J Wave

1996 • 801 citations

Mutations in the hminK gene cause long QT syndrome and suppress lKs function

1997 • 763 citations

QT interval prolongation as predictor of sudden death in patients with myocardial infarction.

1978 • 760 citations

Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells.

1991 • 731 citations

Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs

1993 • 702 citations

An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study)

1992 • 698 citations

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current.

1989 • 675 citations

Terfenadine-Ketoconazole Interaction

1993 • 654 citations

Sex differences in the evolution of the electrocardiographic QT interval with age.

1992 • 634 citations

Mechanism of the Cardiotoxic Actions of Terfenadine

1993 • 627 citations

Characteristics of the Delayed Rectifier Current (I_Krand I_Ks) in Canine Ventricular Epicardial, Midmyocardial, and Endocardial Myocytes

1995 • 605 citations

Treatment of torsade de pointes with magnesium sulfate.

1988 • 590 citations

Quinidine Syncope

1964 • 570 citations

Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de Pointes

2002 • 559 citations

Torsades de pointes occurring in association with terfenadine use

1990 • 550 citations

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization

2006 • 521 citations

Mutant Caveolin-3 Induces Persistent Late Sodium Current and Is Associated With Long-QT Syndrome

2006 • 502 citations

Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic

2001 • 497 citations

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: Clinical and regulatory implications Report on a Policy Conference of the European Society of Cardiology

2000 • 491 citations

Incidence and clinical features of the quinidine-associated long QT syndrome: Implications for patient care

1986 • 489 citations

Efficacy and Safety of Repeated Intravenous Doses of Ibutilide for Rapid Conversion of Atrial Flutter or Fibrillation

1996 • 484 citations

Clinical relevance of cardiac arrhythmias generated by afterdepolarizations

1994 • 483 citations

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

2000 • 477 citations

Torsade de pointes: The long-short initiating sequence and other clinical features: observations in 32 patients

1983 • 466 citations

Characteristics and Distribution of M Cells in Arterially Perfused Canine Left Ventricular Wedge Preparations

1998 • 449 citations

Extracellular Potassium Modulation of Drug Block of I _Kr

1996 • 437 citations

Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval

2002 • 429 citations

A comparison of commonly used QT correction formulae: The effect of heart rate on the QTc of normal ECGs

2004 • 423 citations

Torsade de Pointes Associated with Very-High-Dose Methadone

2002 • 415 citations

[Ventricular tachycardia with 2 variable opposing foci].

1966 • 396 citations

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

2009 • 386 citations

Most LQT2 Mutations Reduce Kv11.1 (hERG) Current by a Class 2 (Trafficking-Deficient) Mechanism

2006 • 384 citations

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

2007 • 377 citations

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1992 • 373 citations

Restricting Excessive Cardiac Action Potential and QT Prolongation

2005 • 373 citations

Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels

1999 • 359 citations

SCN4B -Encoded Sodium Channel β4 Subunit in Congenital Long-QT Syndrome

2007 • 353 citations

KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome

1997 • 347 citations

Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length.

1985 • 341 citations

Drug‐Induced Torsades de Pointes and Implications for Drug Development

2004 • 338 citations

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia

1995 • 337 citations

Electrical heterogeneity within the ventricular wall

2001 • 330 citations

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

2007 • 327 citations

Syntrophin mutation associated with long QT syndrome through activation of the nNOS–SCN5A macromolecular complex

2008 • 319 citations

Evidence for a Cardiac Ion Channel Mutation Underlying Drug‐Induced QT Prolongation and Life‐Threatening Arrhythmias

2000 • 313 citations

Prolonged QT interval predicts cardiac and all-cause mortality in the elderly The Rotterdam Study

1999 • 296 citations

Mechanisms of Arsenic-Induced Prolongation of Cardiac Repolarization

2004 • 281 citations

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

2008 • 279 citations

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1 , and KCNE2 in drug-induced long QT syndrome patients

2004 • 279 citations

Modulating effects of age and gender on the clinical course of long QT syndrome by genotype

2003 • 275 citations

Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion

2006 • 269 citations

Relation between QT intervals and heart rates from 40 to 120 beats/min in rest electrocardiograms of men and a simple method to adjust QT interval values

1994 • 267 citations

Enhanced Ca ²⁺ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes

2000 • 263 citations

Physicochemical Features of the hERG Channel Drug Binding Site

2004 • 259 citations

Pentamidine-Induced Long QT Syndrome and Block of hERG Trafficking

2004 • 258 citations

Genetics of acquired long QT syndrome

2005 • 258 citations

Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle

2001 • 253 citations

Stereoselective Block of hERG Channel by (S)-Methadone and QT Interval Prolongation in CYP2B6 Slow Metabolizers

2007 • 251 citations

Reverse Remodeling of the Left Cardiac Chambers After Catheter Ablation After 1 Year in a Series of Patients With Isolated Atrial Fibrillation

2005 • 248 citations

Electrophysiological and Beta-Receptor Blocking Effects of MJ 1999 on Dog and Rabbit Cardiac Tissue

1970 • 245 citations

Enhanced Susceptibility for Acquired Torsade de Pointes Arrhythmias in the Dog With Chronic, Complete AV Block Is Related to Cardiac Hypertrophy and Electrical Remodeling

1998 • 243 citations

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

1996 • 243 citations

[RARE CARDIAC ARRYTHMIAS OF THE PEDIATRIC AGE. II. SYNCOPAL ATTACKS DUE TO PAROXYSMAL VENTRICULAR FIBRILLATION. (PRESENTATION OF 1ST CASE IN ITALIAN PEDIATRIC LITERATURE)].

1963 • 241 citations

QTU-Prolongation and Torsades de Pointes Induced by Putative Class III Antiarrhythmic Agents in the Rabbit

1990 • 238 citations

The Morphology of the QT Interval Predicts Torsade de Pointes During Acquired Bradyarrhythmias

2007 • 235 citations

Determinants of Prolonged QT Interval and Their Contribution to Sudden Death Risk in Coronary Artery Disease

2009 • 230 citations

Block of HERG Potassium Channels by the Antihistamine Astemizole and its Metabolites Desmethylastemizole and Norastemizole

1999 • 223 citations

Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations

1993 • 218 citations

Efficacy and proarrhythmic hazards of pharmacologic cardioversion of atrial fibrillation: Prospective comparison of sotalol versus quinidine

1995 • 212 citations

Subunit Interaction Determines I _Ks Participation in Cardiac Repolarization and Repolarization Reserve

2005 • 209 citations

Gender difference in the cycle length-dependent QT and potassium currents in rabbits.

1998 • 208 citations

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD

2005 • 201 citations

Novel Mechanism Associated With an Inherited Cardiac Arrhythmia

1999 • 193 citations

Reproducible Induction of Early Afterdepolarizations and Torsade de Pointes Arrhythmias by d -Sotalol and Pacing in Dogs With Chronic Atrioventricular Block

1995 • 192 citations

Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

2010 • 191 citations

Drug‐induced long QT syndrome: hERG K⁺ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine

2006 • 187 citations

Genetic Variations in Nitric Oxide Synthase 1 Adaptor Protein Are Associated With Sudden Cardiac Death in US White Community-Based Populations

2009 • 184 citations

Drug Block of I Kr : Model Systems and Relevance to Human Arrhythmias

2001 • 176 citations

Increased Atrial Fibrillation Mortality: United States, 1980-1998

2002 • 176 citations

Cardiotoxic effect with convulsions in terfenadine overdose.

1989 • 168 citations

Sudden Death During Treatment With Phenothiazine Derivatives

1965 • 165 citations

Rapid Inactivation Determines the Rectification and [K ⁺ ] _o Dependence of the Rapid Component of the Delayed Rectifier K ⁺ Current in Cardiac Cells

1997 • 164 citations

Defining the Cellular Phenotype of “Ankyrin-B Syndrome” Variants

2007 • 162 citations

Quinidine-induced inhibition of transient outward current in cardiac muscle

1987 • 160 citations

Transmural Heterogeneity of Ventricular Repolarization Under Baseline and Long QT Conditions in the Canine Heart In Vivo: Torsades de Pointes Develops with Halothane but not Pentobarbital Anesthesia

2000 • 158 citations

Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome

1995 • 157 citations

D85N, a KCNE1 Polymorphism, Is a Disease-Causing Gene Variant in Long QT Syndrome

2009 • 152 citations

Clinical safety profile of sotalol in patients with arrhythmias

1990 • 152 citations

The differential effect of quinidine and pyrilamine on the myocardial action potential at various rates of stimulation.

1957 • 150 citations

CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart

2008 • 148 citations

The Effect of Moxifloxacin on QTc and Implications for the Design of Thorough QT Studies

2008 • 148 citations

Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsades de pointes

1992 • 146 citations

Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: Distinguishing a drug effect from spontaneous variability

1996 • 143 citations

Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

2001 • 142 citations

Blinded Test in Isolated Female Rabbit Heart Reliably Identifies Action Potential Duration Prolongation and Proarrhythmic Drugs: Importance of Triangulation, Reverse Use Dependence, and Instability

2003 • 135 citations

Pharmacological Rescue of Human K ⁺ Channel Long-QT2 Mutations

2002 • 134 citations

Sodium Pentobarbital Reduces Transmural Dispersion of Repolarization and Prevents Torsades de Pointes in Models of Acquired and Congenital Long QT Syndrome

1999 • 133 citations

Pentamidine reduces hERG expression to prolong the QT interval

2005 • 132 citations

Drugs, QTc Interval Prolongation and Final ICH E14 Guideline

2005 • 130 citations

In vivo and in vitro antiarrhythmic and arrhythmogenic effects of N-acetyl procainamide.

1981 • 123 citations

Antiarrhythmic drugs and torsade de pointes

1993 • 122 citations

Cardiac Sodium Channel Gene Variants and Sudden Cardiac Death in Women

2007 • 120 citations

Sotalol: An important new antiarrhythmic

1999 • 118 citations

Acceleration‐Induced Action Potential Prolongation and Early Afterdepolarizations

1998 • 117 citations

The Antidepressant Drug Fluoxetine Is an Inhibitor of Human Ether-A-Go-Go-Related Gene (HERG) Potassium Channels

2002 • 116 citations

THE ESTIMATION OF QUININE IN HUMAN PLASMA WITH A NOTE ON THE ESTIMATION OF QUINIDINE

1943 • 116 citations

Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil

2005 • 114 citations

Calmodulin Kinase Inhibition Prevents Development of the Arrhythmogenic Transient Inward Current

1999 • 113 citations

Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3 , as Regulators of Myocardial Repolarization

2009 • 112 citations

Modulation of HERG affinity for E‐4031 by [K⁺]_o and C‐type inactivation

1997 • 112 citations

Giant T–U Waves Precede Torsades de Pointes in Long QT Syndrome

2009 • 111 citations

Quinidine delays IK activation in guinea pig ventricular myocytes.

1988 • 109 citations

Use of Terfenadine and Contraindicated Drugs

1996 • 107 citations

Combined pharmacological block of I_Kr and I_Ks increases short‐term QT interval variability and provokes torsades de pointes

2007 • 107 citations

Identification of I_Kr and Its Trafficking Disruption Induced by Probucol in Cultured Neonatal Rat Cardiomyocytes

2007 • 106 citations

Torsade De Pointes Induced by Cisapride/Clarithromycin Interaction

1999 • 102 citations

An Increase in Late Sodium Current Potentiates the Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in Female Rabbit Hearts

2005 • 99 citations

Amiodarone and Torsade de Pointes

1989 • 95 citations

Torsade de Pointes with an antihistamine metabolite: Potassium channel blockade with desmethylastemizole

1996 • 94 citations

Feedback Remodeling of Cardiac Potassium Current Expression

2008 • 92 citations

The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada11This study is based in part on data provided by the Saskatchewan Department of Health. The interpretation and conclusions contained herein do not necessarily represent those of the Government of Saskatchewan or the Saskatchewan Department of Health.

1999 • 91 citations

The canine model with chronic, complete atrio-ventricular block

2008 • 91 citations

Exaggerated QT prolongation after cardioversion of atrial fibrillation

1999 • 90 citations

Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation

2006 • 90 citations

Drug-induced spatial dispersion of repolarization.

2008 • 87 citations

Thorough QT/QTc Not So Thorough: Removes Torsadogenic Predictors from the T‐Wave, Incriminates Safe Drugs, and Misses Profibrillatory Drugs

2006 • 87 citations

METABOLIC PRODUCTS OF THE CINCHONA ALKALOIDS IN HUMAN URINE

1951 • 87 citations

A Rabbit Langendorff Heart Proarrhythmia Model: Predictive Value for Clinical Identification of Torsades de Pointes

2006 • 86 citations

Drug-induced torsades de pointes: The evolving role of pharmacogenetics

2005 • 85 citations

No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic‐AV block

2006 • 79 citations

Genetic susceptibility to acquired long QT syndrome: Pharmacologic challenge in first-degree relatives

2005 • 78 citations

Effects of quinidine on plateau currents of guinea-pig ventricular myocytes

1986 • 77 citations

Strategies to reduce the risk of drug‐induced QT interval prolongation: a pharmaceutical company perspective

2008 • 77 citations

Death associated with ventricular arrhythmia and thioridazine hydrochloride.

1968 • 76 citations

Preclinical Torsades-de-Pointes Screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

2008 • 75 citations

Mechanism of arrhythmogenicity of the short–long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome

1999 • 73 citations

A sensitive mechanism for cation modulation of potassium current

2000 • 67 citations

Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effect of the class III antiarrhythmic agent almokalant

1994 • 67 citations

Torsade de pointes ventricular tachycardia associated with astemizole overdose

1988 • 66 citations

Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3

2005 • 65 citations

CINCHONA DERIVATIVES IN THE TREATMENT OF HEART DISORDERS

1923 • 63 citations

Drug‐Induced QT Interval Prolongation—Regulatory Guidance and Perspectives on hERG Channel Studies

2005 • 61 citations

Dysrhythmia associated with fluoxetine treatment in an elderly patient with cardiac disease.

1991 • 60 citations

Death Associated With Ventricular Arrhythmia and Thioridazine Hydrochloride

1968 • 60 citations

Drug-induced long QT syndrome in women: Review of current evidence and remaining gaps

2008 • 59 citations

Electrophysiological parameters indicative of sudden cardiac death in the dog with chronic complete AV-block

2001 • 58 citations

N-Acetyl procainamide causing torsades de pointes

1982 • 58 citations

Preclinical assessment of drug-induced proarrhythmias: Role of the arterially perfused rabbit left ventricular wedge preparation

2008 • 58 citations

Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes

2006 • 57 citations

New Mechanism Contributing to Drug-Induced Arrhythmia

2005 • 55 citations

Quinidine delays IK activation in guinea pig ventricular myocytes.

1988 • 55 citations

Quinidine syncope: torsade de pointes with low quinidine plasma concentrations.

1976 • 55 citations

Magnesium treatment of ventricular arrhythmias

1989 • 53 citations

Computer Aided Development of Antiarrhythmic Agents with Class III_a Properties

1994 • 53 citations

Chromanol 293B Inhibits Slowly Activating Delayed Rectifier and Transient Outward Currents in Canine Left Ventricular Myocytes

2001 • 52 citations

Plasma concentrations of quinidine, its major metabolites, and dihydroquinidine in patients with torsades de pointes

1988 • 51 citations

Persistent Atrial Fibrillation Is Associated With Reduced Risk of Torsades de Pointes in Patients With Drug-Induced Long QT Syndrome

2008 • 49 citations

Torsade de pointes associated with moxifloxacin: A rare but potentially fatal adverse event

2007 • 48 citations

Combined use of astemizole and ketoconazole resulting in torsade de pointes.

1997 • 47 citations

Proarrhythmic Effects of Intravenous Quinidine, Amiodarone, d -Sotalol, and Almokalant in the Anesthetized Rabbit Model of Torsade de Pointes

2002 • 47 citations

Torsade de pointes induced by N-Acetylprocainamide

1984 • 45 citations

Antimony-Based Antileishmanial Compounds Prolong the Cardiac Action Potential by an Increase in Cardiac Calcium Currents

2006 • 41 citations

Model systems for the discovery and development of antiarrhythmic drugs

2008 • 41 citations

The pause that refreshes, or does it? Mechanisms in torsades de pointes

2000 • 40 citations

Observations on the onset of Torsade de Pointes arrhythmias in the acquired long QT syndrome

2000 • 40 citations

Polymorphous Ventricular Tachycardia and Atrioventricular Block

1986 • 39 citations

The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes

2008 • 39 citations

Use of the Mesoridazine/Thioridazine Ratio as a Marker for CYP2D6 Enzyme Activity

2000 • 38 citations

Moxifloxacin and Torsade de Pointes

2007 • 37 citations

Modulation of Cardiac Inward Rectifier K+ Current by Halothane and Isoflurane

2000 • 37 citations

Temporal decline in filling prescriptions for terfenadine closely in time with those for either ketoconazole or erythromycin*

1997 • 36 citations

NovelKCNE3mutation reduces repolarizing potassium current and associated with long QT syndrome

2009 • 35 citations

hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

2008 • 34 citations

Sex Modulates the Arrhythmogenic Substrate in Prepubertal Rabbit Hearts with Long QT 2

2005 • 34 citations

[The long QT syndrome and syncope caused by spike torsades].

1970 • 34 citations

Moxifloxacin-induced torsades de pointes.

2008 • 34 citations

Near‐Thorough QT Study as Part of a First‐In‐Man Study

2008 • 31 citations

Models of torsades de pointes: Effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts

2009 • 31 citations

A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers

2008 • 30 citations

CLINICAL STUDIES OF QUINIDIN

1922 • 30 citations

The Impact of Ancillary Subunits on Small-Molecule Interactions with Voltage-Gated Potassium Channels

2006 • 30 citations

Comparative in vitro electrophysiology of quinidine, its major metabolites and dihydroquinidine.

1987 • 30 citations

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: A database review and analysis

2008 • 29 citations

Relevance of anaesthesia for dofetilide‐induced torsades de pointes in α₁‐adrenoceptor‐stimulated rabbits

2007 • 28 citations

There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle

2009 • 28 citations

Modulation of Cardiac Inward Rectifier K+ Current by Halothane and Isoflurane

2000 • 27 citations

A Rate‐Independent Method of Assessing QT‐RR Slope Following Conversion of Atrial Fibrillation

2007 • 26 citations

Frequency-dependent interactions of mexiletine and quinidine on depolarization and repolarization in canine Purkinje fibers.

1987 • 26 citations

Importance of QT Interval Determination and Renal Function Assessment During Antiarrhythmic Drug Therapy

2001 • 25 citations

Impact of baseline ECG collection on the planning, analysis and interpretation of ‘thorough’ QT trials

2008 • 22 citations

[Systemic amyloidosis: localization in the gallbladder].

2000 • 21 citations

Delayed Sodium Channel Inactivation Mimics Long QT Syndrome 3

2003 • 16 citations

Proarrhythmic effects of a quinidine analog in dogs with chronic A‐V block

1995 • 14 citations

Mechanisms of action of class III agents and their clinical relevance.

2000 • 12 citations

Use of in vitro methods to predict QT prolongation

2005 • 12 citations

Deleted Work

1955 • 0 citations