Modulation of Cardiac Inward Rectifier K+ Current by Halothane and Isoflurane

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Molecular and cellular mechanisms of general anaesthesia

1994 • 1,779 citations

Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification

1994 • 847 citations

Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+

1987 • 597 citations

Spermine and Spermidine as Gating Molecules for Inward Rectifier K ⁺ Channels

1994 • 520 citations

Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions.

1987 • 495 citations

Strong voltage-dependent inward rectification of inward rectifier K+ channels is caused by intracellular spermine

1995 • 354 citations

Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver.

1991 • 348 citations

Voltage‐dependent magnesium block of adenosine‐triphosphate‐sensitive potassium channel in guinea‐pig ventricular cells.

1987 • 301 citations

Modulation and Block of Ion Channels: A New Biology of Polyamines

1997 • 256 citations

Open‐state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea‐pig heart cells.

1988 • 239 citations

Myocardial Potassium Channels: Electrophysiological and Molecular Diversity

1996 • 230 citations

The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyamines.

1995 • 217 citations

Inward Rectification and Implications for Cardiac Excitability

1996 • 168 citations

The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea‐pig cardiac myocytes.

1989 • 158 citations

MODULATION OF CARDIAC ION CHANNELS BY MAGNESIUM

1991 • 152 citations

Potassium Channels

1999 • 76 citations

Novel Gating Mechanism of Polyamine Block in the Strong Inward Rectifier K Channel Kir2.1

1999 • 53 citations

Halothane and isoflurane preferentially depress a slowly inactivating component of Ca2+ channel current in guinea‐pig myocytes.

1996 • 50 citations

Voltage-Dependent Effects of Volatile Anesthetics on Cardiac Sodium Current

1997 • 50 citations

Myocardial Depressant Effects of Sevoflurane

1997 • 48 citations

Effects of Volatile Anesthetic Isoflurane on ATP-Sensitive K+Channels in Rabbit Ventricular Myocytes

1996 • 44 citations

Halothane acts on many potassium channels, including a minimal potassium channel

1993 • 32 citations

Voltage-Dependent Effects of Volatile Anesthetics on Cardiac Sodium Current

1997 • 31 citations

Effects of sevoflurane on inward rectifier K+ current in guinea pig ventricular cardiomyocytes

1997 • 21 citations

IK1 blockade is unlikely to be a useful antiarrhythmic mechanism

1994 • 13 citations

Deleted Work

1955 • 0 citations