Use of in vitro methods to predict QT prolongation

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

2003 • 1,471 citations

Drug induced QT prolongation and torsades de pointes

2003 • 918 citations

Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties

2004 • 679 citations

Instability and Triangulation of the Action Potential Predict Serious Proarrhythmia, but Action Potential Duration Prolongation Is Antiarrhythmic

2001 • 497 citations

Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome: Insights from a CoMFA Study of HERG K⁺ Channel Blockers

2002 • 371 citations

Cellular mechanisms underlying the long QT syndrome

2002 • 317 citations

Assessing predictors of drug-induced torsade de pointes

2003 • 306 citations

HERG K+ channels: friend and foe

2001 • 284 citations

Mechanisms of Arsenic-Induced Prolongation of Cardiac Repolarization

2004 • 281 citations

Divergent Proarrhythmic Potential of Macrolide Antibiotics Despite Similar QT Prolongation: Fast Phase 3 Repolarization Prevents Early Afterdepolarizations and Torsade de Pointes

2002 • 233 citations

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

2003 • 218 citations

Antagonism by Ranolazine of the Pro-Arrhythmic Effects of Increasing Late INa in Guinea Pig Ventricular Myocytes

2004 • 216 citations

IKr: The hERG Channel

2001 • 178 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

2002 • 166 citations

Analysis of T-Wave Morphology From the 12-Lead Electrocardiogram for Prediction of Long-Term Prognosis in Male US Veterans

2002 • 163 citations

Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K⁺ Channel. A Model for Bad Behavior

2003 • 161 citations

Blinded Test in Isolated Female Rabbit Heart Reliably Identifies Action Potential Duration Prolongation and Proarrhythmic Drugs: Importance of Triangulation, Reverse Use Dependence, and Instability

2003 • 135 citations

[3H]Dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen

2001 • 128 citations

Electrophysiologic Properties and Antiarrhythmic Actions of a Novel Antianginal Agent

2004 • 126 citations

High Throughput Ion-Channel Pharmacology: Planar-Array-Based Voltage Clamp

2003 • 119 citations

Nonclinical proarrhythmia models: Predicting Torsades de Pointes

2005 • 116 citations

Towards a drug concentration effect relationship for QT prolongation and torsades de pointes.

2002 • 114 citations

Ranolazine: Ion‐channel‐blocking actions and in vivo electrophysiological effects

2004 • 106 citations

Detection of Proarrhythmia in the Female Rabbit Heart:

2003 • 96 citations

Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice

2004 • 86 citations

Comparison of the In Vitro Electrophysiologic and Proarrhythmic Effects of Amiodarone and Sotalol in a Rabbit Model of Acute Atrioventricular Block

2004 • 83 citations

Development and Evaluation of High Throughput Functional Assay Methods for hERG Potassium Channel

2001 • 82 citations

Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia

2003 • 77 citations

Electrophysiological Safety of Sertindole in Dogs with Normal and Remodeled Hearts

2003 • 72 citations

A High-Throughput HERG Potassium Channel Function Assay: An Old Assay with a New Look

2002 • 69 citations

Molecular determinants of high-affinity drug binding to HERG channels.

2003 • 63 citations

THE CARDIAC ION CHANNELS: Relevance to Management of Arrhythmias

1996 • 54 citations

Differential Effects of D‐Sotalol, Quinidine, and Amiodarone on Dispersion of Ventricular Repolarization in the Isolated Rabbit Heart

1997 • 51 citations

HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery.

2003 • 43 citations

Romano-Ward and other congenital long QT syndromes.

2002 • 4 citations