Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

1995 • 2,391 citations

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1995 • 2,263 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Genetic applications of an inverse polymerase chain reaction.

1988 • 1,867 citations

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1995 • 1,686 citations

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval, and sudden death

1957 • 1,593 citations

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1995 • 1,216 citations

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

1985 • 1,207 citations

Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products

1991 • 1,182 citations

Effect of the Antiarrhythmic Agent Moricizine on Survival after Myocardial Infarction

1992 • 969 citations

Determination of the subunit stoichiometry of a voltage-activated potassium channel

1991 • 925 citations

The long Q-T syndrome

1975 • 901 citations

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.

1964 • 842 citations

Long QT Syndrome Patients With Mutations of the SCN5A and HERG Genes Have Differential Responses to Na ⁺ Channel Blockade and to Increases in Heart Rate

1995 • 801 citations

The long QT syndrome

1997 • 709 citations

Circadian variation in the incidence of sudden cardiac death in the framingham heart study population

1987 • 657 citations

Linkage of a Cardiac Arrhythmia, the Long QT Syndrome, and the Harvey ras -1 Gene

1991 • 526 citations

Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction.

1990 • 454 citations

Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.

1988 • 443 citations

Unilateral Cervicothoracic Sympathetic Ganglionectomy for the Treatment of Long QT Interval Syndrome

1971 • 427 citations

Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.

1991 • 425 citations

Mapping of a gene for long QT syndrome to chromosome 4q25-27.

1995 • 356 citations

Use of cyclosporin a in establishing epstein-barr virus-transformed human lymphoblastoid cell lines

1984 • 355 citations

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia

1995 • 337 citations

Isolation of genes from complex sources of mammalian genomic DNA using exon amplification

1994 • 276 citations

Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity

1994 • 270 citations

Bacteriophage P1 cloning system for the isolation, amplification, and recovery of DNA fragments as large as 100 kilobase pairs.

1990 • 270 citations

Shaker, Shal, Shab, and Shaw express independent K+ current systems

1991 • 256 citations

Functional Stoichiometry of Shaker Potassium Channel Inactivation

1993 • 186 citations

Sudden death risk in overt coronary heart disease: The Framingham Study

1987 • 183 citations

CONGENITAL CARDIAC ARRHYTHMIA

1964 • 133 citations

Consistent linkage of the long-QT syndrome to the Harvey ras-1 locus on chromosome 11.

1991 • 111 citations

Proarrhythmic effects of antiarrhythmic drugs

1987 • 110 citations

Isolation and mapping of 62 new RFLP markers on human chromosome 11.

1991 • 109 citations

Rapid identification of yeast artificial chromosome clones by matrix pooling and crude Iysate PCR

1990 • 77 citations

Increased exon-trapping efficiency through modifications to the pSPL3 splicing vector

1995 • 70 citations

Genomic Organization, Nucleotide Sequence, Biophysical Properties, and Localization of the Voltage-Gated K+ Channel Gene KCNA4/Kv1.4 to Mouse Chromosome 2/Human 11p14 and Mapping of KCNC1/Kv3.1 to Mouse 7/Human 11p14.3-p15.2 and KCNA1/Kv1.1 to Human 12p13

1994 • 36 citations

Mapping of 262 DNA markers into 24 intervals on human chromosome 11.

1992 • 35 citations

Isolation of P1 insert ends by direct sequencing.

1994 • 7 citations