Proarrhythmic Effects of Intravenous Quinidine, Amiodarone, d -Sotalol, and Almokalant in the Anesthetized Rabbit Model of Torsade de Pointes

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1988 • 1,099 citations

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1986 • 489 citations

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2000 • 422 citations

QTU-Prolongation and Torsades de Pointes Induced by Putative Class III Antiarrhythmic Agents in the Rabbit

1990 • 238 citations

Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations

1993 • 218 citations

The adrenergic antagonism of amiodarone

1976 • 165 citations

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1997 • 157 citations

Experimental models of torsade de pointes

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Torsades de pointes associated with drugs and toxins: Recognition and management

1987 • 137 citations

Antiarrhythmic Actions of Amiodarone: A Profile of a Paradoxical Agent

1996 • 120 citations

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1993 • 117 citations

Further Observations to Elucidate the Role of Interventricular Dispersion of Repolarization and Early Afterdepolarizations in the Genesis of Acquired Torsade de Pointes Arrhythmias

1997 • 115 citations

Electrophysiologic effects of amiodarone: Experimental and clinical observation relative to serum and tissue drug concentrations

1984 • 109 citations

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1996 • 109 citations

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1993 • 99 citations

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1987 • 99 citations

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1997 • 96 citations

Comparative Assessment of Ibutilide, D-Sotalol, Clofilium, E-4031, and UK-68, 798 in a Rabbit Model of Proarrhythmia

1993 • 96 citations

Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes

1996 • 75 citations

Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium: I. In vitro study.

1997 • 75 citations

Experimental models of torsades de pointes

1993 • 55 citations

Differential effects of the new class III antiarrhythmic agents almokalant, E-4031 and D-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes

1992 • 54 citations

Rhythm anomalies related to delayed repolarization in vivo: influence of sarcolemmal Ca++ entry and intracellular Ca++ overload.

1996 • 48 citations

Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit.

1993 • 47 citations

Selective inhibition of potassium currents in rat ventricle by clofilium and its tertiary homolog.

1991 • 44 citations

Comparative β-blocking activities and electrophysiologic actions of racemic sotalol and its optical isomers in anesthetized dogs

1986 • 44 citations

Nonselective IKr-Blockers Do not Induce Torsades de Pointes in the Anesthetized Rabbit During α1-Adrenoceptor Stimulation

2000 • 40 citations

Quinidine is a competitive antagonist at alpha 1- and alpha 2-adrenergic receptors.

1984 • 38 citations

Anesthetized rabbit as a model for ischemia- and reperfusion-induced arrhythmias: Effects of quinidine and bretylium

1989 • 36 citations

Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide‐sensitive K⁺ currents in Xenopus oocytes

1993 • 33 citations

Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential

2001 • 30 citations

Pharmacodynamic, Pharmacokinetic and Antiarrhythmic Properties of d-Sotalol, the Dextro-Isomer of Sotalol

1995 • 30 citations

Torsades de pointes with Almokalant, a new class III antiarrhythmic drug

1993 • 28 citations

Acute and Chronic Effects of Amiodarone on Mammalian Ventricular Cells.

1996 • 27 citations

Proarrhythmia of Azimilide and Other Class III Antiarrhythmic Agents in the Adrenergically Stimulated Rabbit

2000 • 18 citations

Comparison of the antiarrhythmic and the proarrhythmic effect of almokalant in anaesthetised rabbits

1998 • 17 citations

Early Proarrhythmia During Intravenous Amiodarone Treatment

1999 • 17 citations

Selectivity of Class-III Antiarrhythmic Action of Clofilium in Guinea Pig Ventricular Myocytes

1996 • 14 citations

Cardiac electrophysiologic effects of acute and chronic amiodarone administration in the isolated perfused rabbit heart: altered thyroid hormone metabolism.

1986 • 14 citations

Proarrhythmic effects of a quinidine analog in dogs with chronic A‐V block

1995 • 14 citations

Antiarrhythmic and electrophysiological effects of GYKI-16638, a novel N-(phenoxyalkyl)-N-phenylalkylamine, in rabbits

2000 • 13 citations

Serum and Myocardial Kinetics of Amiodarone and Its Deethyl Metabolite After Intravenous Administration in Rabbits

1984 • 11 citations

Torsades de Pointes and Ventricular Fibrillation in a Canine Model of Quinidine‐induced QT Prolongation

1992 • 7 citations

Animal Models of the Long QT Syndrome:

1997 • 5 citations

Anticholinergic action of quinidine sulfate in the rabbit atrioventricular node

1990 • 4 citations

Effects of ring fluorination on the adrenergic properties of phenylephrine

1987 • 4 citations