Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

1992 • 1,616 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

1993 • 1,083 citations

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

1997 • 1,047 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice

1994 • 1,000 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons

1994 • 934 citations

A missense mutation of the endothelin-B receptor gene in multigenic hirschsprung's disease

1994 • 886 citations

Nuclear localization of β-catenin by interaction with transcription factor LEF-1

1996 • 864 citations

SOX10 mutations in patients with Waardenburg-Hirschsprung disease

1998 • 806 citations

nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate

1999 • 781 citations

Sox10, a Novel Transcriptional Modulator in Glial Cells

1998 • 759 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

SOX10 mutation disrupts neural crest development in Dom Hirschsprung mouse model

1998 • 725 citations

Drosophila Tcf and Groucho interact to repress Wingless signalling activity

1998 • 722 citations

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

1992 • 692 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

1998 • 679 citations

Wnt signalling required for expansion of neural crest and CNS progenitors

1997 • 669 citations

Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene

1994 • 661 citations

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.

1994 • 652 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes

1998 • 617 citations

A β-catenin/XTcf-3 complex binds to thesiamois promoter to regulate dorsal axis specification in Xenopus

1997 • 527 citations

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi

2000 • 517 citations

Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences

1994 • 503 citations

Control of neural crest cell fate by the Wnt signalling pathway

1998 • 501 citations

Nerve Growth Factor Activates Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways To Stimulate CREB Serine 133 Phosphorylation

1998 • 495 citations

In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.

1991 • 479 citations

Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes

1998 • 478 citations

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1998 • 468 citations

Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer

2000 • 467 citations

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB

1992 • 458 citations

Melanocyte-Specific Expression of the Human Tyrosinase Promoter: Activation by the Microphthalmia Gene Product and Role of the Initiator

1994 • 415 citations

Another role for melanocytes: their importance for normal stria vascularis development in the mammalian inner ear

1989 • 405 citations

The temporal requirement for endothelin receptor-B signalling during neural crest development

1999 • 347 citations

Regulation of Wnt Signaling by Sox Proteins

1999 • 342 citations

Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses

2000 • 341 citations

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

1989 • 337 citations

Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3

2000 • 336 citations

The function of melanin or six blind people examine an elephant

1992 • 325 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

Activation of the Receptor Tyrosine Kinase Kit Is Required for the Proliferation of Melanoblasts in the Mouse Embryo

1997 • 317 citations

Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development

1999 • 315 citations

Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a

2000 • 314 citations

Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3′-kinase is essential for male fertility

2000 • 313 citations

Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator.

1994 • 309 citations

Different cis-Acting Elements Are Involved in the Regulation of TRP1 and TRP2 Promoter Activities by Cyclic AMP: Pivotal Role of M Boxes (GTCATGTGCT) and of Microphthalmia

1998 • 304 citations

Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

1993 • 301 citations

Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor

1997 • 290 citations

Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway

1995 • 280 citations

MOLECULAR AND DEVELOPMENTAL GENETICS OF MOUSE COAT COLOR

1994 • 280 citations

Epistatic relationship between Waardenburg Syndrome genes MITF and PAX3

1998 • 276 citations

Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway

2000 • 265 citations

A helix-loop-helix transcription factor-like gene is located at the mi locus.

1993 • 253 citations

Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics

1996 • 252 citations

Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/WlacZ mouse embryos

1996 • 247 citations

Microphthalmia Transcription Factor

1999 • 237 citations

Regulation of Microphthalmia-Associated Transcription Factor MITF Protein Levels by Association with the Ubiquitin-Conjugating Enzyme hUBC9

2000 • 234 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2

1993 • 223 citations

CREB is activated by UVC through a p38/HOG-1-dependent protein kinase

1997 • 217 citations

Insight into the microphthalmia gene

1995 • 216 citations

α-Melanocyte-stimulating Hormone Signaling Regulates Expression of microphthalmia, a Gene Deficient in Waardenburg Syndrome

1998 • 216 citations

Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently

1998 • 211 citations

The migratory pathway of neural crest cells into the skin of mouse embryos

1973 • 207 citations

Targeting the Microphthalmia Basic Helix-Loop-Helix–Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo

1998 • 201 citations

Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells

1995 • 200 citations

The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx

1999 • 198 citations

Malignant melanoma: modern black plague and genetic black box

1998 • 198 citations

Lineage-specific Signaling in Melanocytes

1998 • 191 citations

Involvement of Microphthalmia in the Inhibition of Melanocyte Lineage Differentiation and of Melanogenesis by Agouti Signal Protein

1998 • 180 citations

CBP/p300 as a co-factor for the Microphthalmia transcription factor

1997 • 177 citations

Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes.

1995 • 174 citations

Brachyury-Related Transcription Factor Tbx2 and Repression of the Melanocyte-Specific TRP-1 Promoter

1998 • 171 citations

Human TAFII105 Is a Cell Type–Specific TFIID Subunit Related to hTAFII130

1996 • 169 citations

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1998 • 165 citations

Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance

2000 • 160 citations

Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.

1996 • 147 citations

Differential Regulation of Raf-1 and B-Raf and Ras-Dependent Activation of Mitogen-Activated Protein Kinase by Cyclic AMP in PC12 Cells

1995 • 146 citations

Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters

2000 • 141 citations

Positive and negative elements regulate a melanocyte-specific promoter.

1992 • 133 citations

The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription.

1995 • 130 citations

Identification of a Melanocyte-Type Promoter of the Microphthalmia-Associated Transcription Factor Gene

1996 • 128 citations

Sound Needs Sound Melanocytes to Be Heard

1999 • 127 citations

Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter

1999 • 118 citations

Steel Factor and c-kit Protooncogene: Genetic Lessons in Signal Transduction

1994 • 116 citations

A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.

1994 • 116 citations

An L1 Element Intronic Insertion in the Black-Eyed White (Mitfmi-bw) Gene: The Loss of a Single Mitf Isoform Responsible for the Pigmentary Defect and Inner Ear Deafness

1999 • 111 citations

Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice.

1992 • 107 citations

Differentiation in mouse melanoma cells: Initial reversibility and an on-off stochastic model

1983 • 107 citations

Genomic, Transcriptional and Mutational Analysis of the Mouse microphthalmia Locus

2000 • 105 citations

The Gene Encoding the T-box Factor Tbx2 Is a Target for the Microphthalmia-associated Transcription Factor in Melanocytes

2000 • 105 citations

Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.

1994 • 99 citations

The mouse tyrosinase gene. Promoter modulation by positive and negative regulatory elements.

1994 • 94 citations

Molecular Cloning of cDNA Encoding a Novel Microphthalmia- Associated Transcription Factor Isoform with a Distinct Amino-Terminus

1999 • 93 citations

The tyrosinase-related protein-1 gene has a structure and promoter sequence very different from tyrosinase

1991 • 85 citations

The Regulation of Tyrosinase Gene Transcription

1997 • 79 citations

A Big Gene Linked to Small Eyes Encodes Multiple Mitf Isoforms: Many Promoters Make Light Work

1998 • 76 citations

Mutations in PAX3 associated with waardenburg syndrome type I

1994 • 74 citations

A Refractory Phase in Cyclic AMP-Responsive Transcription Requires Down Regulation of Protein Kinase A

1995 • 70 citations

Identification of a cis-acting element that enhances the pigment cell-specific expression of the human tyrosinase gene.

1992 • 70 citations

A distal tyrosinase upstream element stimulates gene expression in neural-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression

1994 • 68 citations

TFE3, a Transcription Factor Homologous to Microphthalmia, Is a Potential Transcriptional Activator of Tyrosinase and TyrpI Genes

2000 • 67 citations

Commitment: How do cells make the decision to differentiate?

1981 • 65 citations

Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF.

1994 • 61 citations

Microphthalmia-Associated Transcription Factor as a Regulator for Melanocyte-Specific Transcription of the Human Tyrosinase Gene

1995 • 57 citations

Involvement ofmi-Transcription Factor in Expression of α-Melanocyte-Stimulating Hormone Receptor in Cultured Mast Cells of Mice

2000 • 56 citations

Characterization of a new melanocyte-specific gene (QNR-71) expressed in v-myc-transformed quail neuroretina.

1996 • 54 citations

Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor.

1997 • 45 citations

Characterization of a new melanocyte-specific gene (QNR-71) expressed in v-myc-transformed quail neuroretina.

1996 • 45 citations

TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription

1995 • 44 citations

Expression of the microphthalmia-associated basic helix-loop-helix leucine zipper transcription factor Mi in avian neuroretina cells induces a pigmented phenotype.

1999 • 37 citations

Involvement of transcription factor encoded by the mouse mi locus (MITF) in apoptosis of cultured mast cells induced by removal of interleukin-3.

1997 • 28 citations

Melanocortin receptors and antagonists regulate pigmentation and body weight

1998 • 25 citations

Mi-spotted: a mutation in the mouse

1964 • 20 citations

Nucleosome assembly on the human c-fos promoter interferes with transcription factor binding

1996 • 19 citations

TFE3, a Transcription Factor Homologous to Microphthalmia, Is a Potential Transcriptional Activator of Tyrosinase and TyrpI Genes

2000 • 19 citations

Melanocyte-Specific Gene Expression: Role of Repression and Identification of a Melanocyte-Specific Factor, MSF

1994 • 12 citations

In Vivo and In Vitro Morphological Analysis of Melanocytes Homozygous for the mi^sp Allele at the Murine Microphthalmia Locus

1995 • 6 citations