The tyrosinase-related protein-1 gene has a structure and promoter sequence very different from tyrosinase

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Genomic sequencing.

1984 • 8,343 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

[16] Splice junctions, branch point sites, and exons: Sequence statistics, identification, and applications to genome project

1990 • 689 citations

An lmproved method for directly sequencing PCR-amplified material using dimethyl sulphoxide

1989 • 608 citations

Mammalian Tyrosinase Catalyzes Three Reactions in the Biosynthesis of Melanin

1982 • 574 citations

Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.

1987 • 448 citations

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

1988 • 432 citations

Intron phylogeny: a new hypothesis

1991 • 361 citations

A reappraisal of non-consensus mRNA splice sites

1991 • 324 citations

Functional analysis of alternatively spliced tyrosinase gene transcripts.

1988 • 275 citations

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

1990 • 271 citations

A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse.

1988 • 247 citations

Cloning and expression of cDNA encoding mouse tyrosinase

1986 • 241 citations

Analysis of Mammalian Pigmentation at the Molecular Level

1989 • 238 citations

Evidence that introns arose at proto-splice sites.

1989 • 235 citations

Organization of the human lipoprotein lipase gene and evolution of the lipase gene family.

1989 • 223 citations

Split-gene evolution: Exon shuffling and intron insertion in serine protease genes

1985 • 217 citations

Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice

1990 • 209 citations

Human oculocutaneous albinism caused by single base insertion in the tyrosinase gene

1989 • 206 citations

5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU

1987 • 206 citations

Xenopus Y-box transcription factors: molecular cloning, functional analysis and developmental regulation.

1990 • 192 citations

Dopachrome Conversion: A Possible Control Point in Melanin Biosynthesis

1980 • 190 citations

Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing.

1988 • 184 citations

Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.

1990 • 182 citations

Organization and nucleotide sequences of the human tyrosinase gene and a truncated tyrosinase-related segment

1991 • 180 citations

The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type.

1990 • 162 citations

Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression

1988 • 156 citations

Do exons code for structural or functional units in proteins?

1988 • 147 citations

Dopachrome Oxidoreductase: A New Enzyme in the Pigment Pathway

1984 • 133 citations

How were introns inserted into nuclear genes?

1989 • 131 citations

Characterization of the gene encoding ovine beta-lactoglobulin

1988 • 116 citations

The mouse tyrosinase promoter is sufficient for expression in melanocytes and in the pigmented epithelium of the retina.

1991 • 113 citations

Primary structure of tyrosinase from Streptomyces glaucescens

1985 • 112 citations

Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA.

1989 • 111 citations

Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene

1990 • 110 citations

A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine → serine substitution at position 85

1990 • 110 citations

The role of introns in evolution

1990 • 97 citations

Detection of Mutations in the Tyrosinase Gene in a Patient with Type IA Oculocutaneous Albinism

1990 • 92 citations

Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant.

1990 • 87 citations

A frequent tyrosinase gene mutation in classic, tyrosinase-negative (type IA) oculocutaneous albinism.

1990 • 75 citations

Molecular basis of tyrosinase-negative oculocutaneous albinism. A single base mutation in the tyrosinase gene causing arginine to glutamine substitution at position 59.

1990 • 75 citations

Molecular basis of mouse Himalayan mutation

1989 • 71 citations

Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.

1990 • 67 citations

Isolation, Chromosomal Mapping, and Expression of the Mouse Tyrosinase Gene

1989 • 60 citations

Detection of point mutation in the tyrosinase gene of a Japanese albino patient by a direct sequencing of amplified DNA

1990 • 38 citations

Characteristic sequences in the upstream region of the human tyrosinase gene

1989 • 35 citations

New regulatory factors for melanogenesis: Developmental changes in neonatal mice of various genotypes

1983 • 27 citations

Primary structure of tyrosinase from Neurospora crassa. I. Purification and amino acid sequence of the cyanogen bromide fragments.

1982 • 26 citations