The Gene Encoding the T-box Factor Tbx2 Is a Target for the Microphthalmia-associated Transcription Factor in Melanocytes

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

1993 • 1,083 citations

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

1997 • 909 citations

Cloning of the T gene required in mesoderm formation in the mouse

1990 • 847 citations

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

1992 • 692 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Expression of the T-box family genes,Tbx1-Tbx5, during early mouse development

1996 • 654 citations

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.

1994 • 652 citations

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

1997 • 536 citations

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi

2000 • 517 citations

Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes

1998 • 478 citations

A line of non‐tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumour promoter for growth

1987 • 475 citations

An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome

1992 • 470 citations

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

1998 • 447 citations

Melanocyte-Specific Expression of the Human Tyrosinase Promoter: Activation by the Microphthalmia Gene Product and Role of the Initiator

1994 • 415 citations

Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6

1998 • 408 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 406 citations

Functional Analysis of Microphthalmia-associated Transcription Factor in Pigment Cell-specific Transcription of the Human Tyrosinase Family Genes

1997 • 383 citations

Crystallographic structure of the T domain–DNA complex of the Brachyury transcription factor

1997 • 327 citations

The Brachyury gene encodes a novel DNA binding protein.

1993 • 308 citations

The T-box gene family

1998 • 307 citations

Different cis-Acting Elements Are Involved in the Regulation of TRP1 and TRP2 Promoter Activities by Cyclic AMP: Pivotal Role of M Boxes (GTCATGTGCT) and of Microphthalmia

1998 • 304 citations

The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity

1999 • 293 citations

Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor

1997 • 290 citations

The T protein encoded by Brachyury is a tissue-specific transcription factor.

1995 • 287 citations

Epistatic relationship between Waardenburg Syndrome genes MITF and PAX3

1998 • 276 citations

Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds

1999 • 264 citations

Regulation of Microphthalmia-Associated Transcription Factor MITF Protein Levels by Association with the Ubiquitin-Conjugating Enzyme hUBC9

2000 • 234 citations

An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

1994 • 225 citations

Insight into the microphthalmia gene

1995 • 216 citations

Targeting the Microphthalmia Basic Helix-Loop-Helix–Leucine Zipper Transcription Factor to a Subset of E-Box Elements In Vitro and In Vivo

1998 • 201 citations

Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.

1981 • 195 citations

Brachyury-Related Transcription Factor Tbx2 and Repression of the Melanocyte-Specific TRP-1 Promoter

1998 • 171 citations

Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice

1998 • 161 citations

Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product.

1996 • 147 citations

Positive and negative elements regulate a melanocyte-specific promoter.

1992 • 133 citations

The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription.

1995 • 130 citations

Brachyury and the T-box genes

1997 • 129 citations

Differential Roles of Upstream Stimulatory Factors 1 and 2 in the Transcriptional Response of Liver Genes to Glucose

1998 • 127 citations

Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter

1999 • 118 citations

Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.

1995 • 107 citations

The mouse tyrosinase gene. Promoter modulation by positive and negative regulatory elements.

1994 • 94 citations

The effect of hyperthermia and melphalan on survival of human fibroblast strains and melanoma cell lines.

1977 • 77 citations

Cloning and Mapping of a Human Gene (TBX2) Sharing a Highly Conserved Protein Motif with the Drosophila omb Gene

1995 • 76 citations

A Combined Analysis of Genomic and Primary Protein Structure Defines the Phylogenetic Relationship of New Members of the T-Box Family

1998 • 71 citations

Identification, Mapping, and Phylogenomic Analysis of Four New Human Members of the T-box Gene Family:EOMES, TBX6, TBX18,andTBX19

1999 • 63 citations

Melanocyte-specific gene expression: role of repression and identification of a melanocyte-specific factor, MSF.

1994 • 61 citations

Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor.

1997 • 45 citations

T-box family reunion

1997 • 44 citations