Computational redesign of protein-protein interaction specificity

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1997 • 33,348 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density

1999 • 2,108 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

Anatomy of hot spots in protein interfaces

1998 • 1,908 citations

Predicting Changes in the Stability of Proteins and Protein Complexes: A Study of More Than 1000 Mutations

2002 • 1,674 citations

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

2003 • 1,619 citations

A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants

1993 • 1,456 citations

Effective energy function for proteins in solution

1999 • 1,269 citations

De Novo Protein Design: Fully Automated Sequence Selection

1997 • 1,129 citations

A simple physical model for binding energy hot spots in protein–protein complexes

2002 • 812 citations

Native protein sequences are close to optimal for their structures

2000 • 811 citations

Bayesian statistical analysis of protein side‐chain rotamer preferences

1997 • 792 citations

Computational Alanine Scanning To Probe Protein−Protein Interactions: A Novel Approach To Evaluate Binding Free Energies

1999 • 741 citations

Computational design of receptor and sensor proteins with novel functions

2003 • 665 citations

Rapid automated molecular replacement by evolutionary search

1999 • 589 citations

An Orientation-dependent Hydrogen Bonding Potential Improves Prediction of Specificity and Structure for Proteins and Protein–Protein Complexes

2003 • 510 citations

High-Resolution Protein Design with Backbone Freedom

1998 • 457 citations

Interrogating protein interaction networks through structural biology

2002 • 343 citations

Automated design of specificity in molecular recognition

2002 • 313 citations

De novo design of the hydrophobic cores of proteins

1995 • 301 citations

Computational alanine scanning of the 1:1 human growth hormone–receptor complex

2001 • 297 citations

Construction of new ligand binding sites in proteins of known structure

1991 • 233 citations

Computer-based redesign of a protein folding pathway.

2001 • 223 citations

The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein

1999 • 186 citations

Computer-aided design of a PDZ domain to recognize new target sequences

2002 • 155 citations

Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes

2000 • 147 citations

Construction of new ligand binding sites in proteins of known structure

1991 • 127 citations

Review: Protein Design—Where We Were, Where We Are, Where We're Going

2001 • 122 citations

Modulating Calmodulin Binding Specificity through Computational Protein Design

2002 • 117 citations

Exploring the origins of binding specificity through the computational redesign of calmodulin

2003 • 113 citations

Conformational strain in the hydrophobic core and its implications for protein folding and design

2002 • 109 citations

SH3-SPOT: an algorithm to predict preferred ligands to different members of the SH3 gene family

2000 • 91 citations

Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases

2003 • 89 citations

Protein-Protein Interactions in Colicin E9 DNase-Immunity Protein Complexes. 2. Cognate and Noncognate Interactions That Span the Millilmolar to Femptomolar Affinity Range

1995 • 88 citations

Selection of Recently Isolated Colicinogenic Escherichia coli Strains Inhibitory to Escherichia coli O157:H7

2002 • 84 citations

Immunity proteins and their specificity for endonuclease colicins: telling right from wrong in protein–protein recognition

1998 • 82 citations

Analysis of protein-protein interactions and the effects of amino acid mutations on their energetics. The importance of water molecules in the binding epitope

1997 • 76 citations

In Vitro Assessment of the Cytotoxicity of Nisin, Pediocin, and Selected Colicins on Simian Virus 40–Transfected Human Colon and Vero Monkey Kidney Cells with Trypan Blue Staining Viability Assays

2003 • 68 citations

Distinct Binding Specificity of the Multiple PDZ Domains of INADL, a Human Protein with Homology to INAD from Drosophila melanogaster

2001 • 63 citations

Evaluation of Models of Electrostatic Interactions in Proteins

2003 • 48 citations

Calculation of HyHel10-lysozyme binding free energy changes: Effect of ten point mutations

1998 • 46 citations

Prudent Modeling of Core Polar Residues in Computational Protein Design

2003 • 44 citations

Virtual interaction profiles of proteins

2001 • 32 citations