Computational Alanine Scanning To Probe Protein−Protein Interactions: A Novel Approach To Evaluate Binding Free Energies

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

1993 • 26,634 citations

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1995 • 12,826 citations

Classical Electrostatics in Biology and Chemistry

1995 • 2,801 citations

Accurate Calculation of Hydration Free Energies Using Macroscopic Solvent Models

1994 • 2,072 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Reduced surface: An efficient way to compute molecular surfaces

1996 • 1,864 citations

High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis

1989 • 1,357 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Regulation of Cocaine Reward by CREB

1998 • 762 citations

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

1998 • 752 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1996 • 544 citations

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

1998 • 310 citations

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

1998 • 279 citations

Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn

1997 • 249 citations

Physical Mapping of a Translocation Breakpoint in Neurofibromatosis

1989 • 136 citations

Molecular and Biochemical Reprogramming of Oncogenesis through the Activity of Prooxidants and Antioxidants

1993 • 99 citations

The application of three approximate free energy calculations methods to structure based ligand design: trypsin and its complex with inhibitors.

1998 • 47 citations

Continents ring the changes

1992 • 43 citations

Another p53 Doppelgänger?

1998 • 24 citations

DNA–Ligand Interactions

2012 • 1 citations