A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1991 • 2,629 citations

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

1981 • 2,490 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

The packing of α-helices: simple coiled-coils

1953 • 1,549 citations

Tertiary templates for proteins

1987 • 1,485 citations

X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled Coil

1991 • 1,433 citations

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

1990 • 1,173 citations

The nature of the accessible and buried surfaces in proteins

1976 • 1,151 citations

A lattice statistical mechanics model of the conformational and sequence spaces of proteins

1989 • 962 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Evidence That the Leucine Zipper Is a Coiled Coil

1989 • 869 citations

Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques

1981 • 845 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

α‐Helical coiled coils and bundles: How to design an α‐helical protein

1990 • 720 citations

Leucine Repeats and an Adjacent DNA Binding Domain Mediate the Formation of Functional cFos-cJun Heterodimers

1989 • 676 citations

Parallel Association of Fos and Jun Leucine Zippers Juxtaposes DNA Binding Domains

1989 • 607 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Relative helix-forming tendencies of nonpolar amino acids

1990 • 455 citations

Side Chain Contributions to the Stability of Alpha-Helical Structure in Peptides

1990 • 455 citations

Trimerization of a yeast transcriptional activator via a coiled-coil motif

1989 • 392 citations

Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions

1990 • 379 citations

Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

1990 • 372 citations

Origins of structure in globular proteins.

1990 • 336 citations

The Fourier transform of a coiled-coil

1953 • 307 citations

Structure of the ColE1 Rop protein at 1.7 Å resolution

1987 • 297 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Crystal Structure of a Synthetic Triple-Stranded α-Helical Bundle

1993 • 281 citations

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

1991 • 265 citations

Internal Stark Effect Measurement of the Electric Field at the Amino Terminus of an α Helix

1992 • 259 citations

Metal Ion-Dependent Modulation of the Dynamics of a Designed Protein

1993 • 252 citations

The role of internal packing interactions in determining the structure and stability of a protein

1991 • 208 citations

Refinement of the influenza virus hemagglutinin by simulated annealing

1990 • 201 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Packing and hydrophobicity effects on protein folding and stability: Effects of β‐branched amino acids, valine and isoleucine, on the formation and stability of two‐stranded α‐helical coiled coils/leucine zippers

1993 • 173 citations

Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins.

1989 • 164 citations

In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core

1991 • 162 citations

Structural features in the heptad substructure and longer range repeats of two-stranded α-fibrous proteins

1990 • 161 citations

Two functionally different regions in Fos are required for the sequence-specific DNA interaction of the Fos/Jun protein complex

1989 • 147 citations

Trimerization of the heat shock transcription factor by a triple-stranded .alpha.-helical coiled-coil

1992 • 146 citations

Secondary structure of a leucine zipper determined by nuclear magnetic resonance spectroscopy

1990 • 139 citations

Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme

1992 • 130 citations

Effect of amino acid ion pairs on peptide helicity

1991 • 89 citations

A de novo designed protein shows a thermally induced transition from a native to a molten globule-like state

1992 • 79 citations

Three-stranded α-fibrous proteins: the heptad repeat and its implications for structure

1991 • 79 citations

Conformationally constrained α‐helical peptide models for protein ion channels

1990 • 75 citations

De novo protein design: what are we learning?

1991 • 60 citations

A four-strand coiled-coil model for some insect fibrous proteins

1967 • 57 citations

The Basic-Region Leucine-Zipper Family of DNA Binding Proteins

1992 • 43 citations

Monte carlo studies on equilibrium globular protein folding. III. The four helix bundle

1989 • 40 citations