A simple physical model for binding energy hot spots in protein–protein complexes

Calculating Structures and Free Energies of Complex Molecules: Combining Molecular Mechanics and Continuum Models

2000 • 4,459 citations

Predicting Deleterious Amino Acid Substitutions

2001 • 2,513 citations

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

1999 • 1,932 citations

Anatomy of hot spots in protein interfaces

1998 • 1,908 citations

Predicting Changes in the Stability of Proteins and Protein Complexes: A Study of More Than 1000 Mutations

2002 • 1,674 citations

Simulation of activation free energies in molecular systems

1996 • 1,279 citations

Effective energy function for proteins in solution

1999 • 1,269 citations

De Novo Protein Design: Fully Automated Sequence Selection

1997 • 1,129 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Native protein sequences are close to optimal for their structures

2000 • 811 citations

Bayesian statistical analysis of protein side‐chain rotamer preferences

1997 • 792 citations

Unraveling hot spots in binding interfaces: progress and challenges

2002 • 759 citations

Computational Alanine Scanning To Probe Protein−Protein Interactions: A Novel Approach To Evaluate Binding Free Energies

1999 • 741 citations

SNPs, protein structure, and disease

2001 • 729 citations

Protein function in the post-genomic era

2000 • 721 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions

2001 • 392 citations

Conservation of polar residues as hot spots at protein interfaces

2000 • 283 citations

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

1998 • 279 citations

Molecular characterization of the hdm2-p53 interaction 1 1Edited by J. Karn

1997 • 249 citations

Design, Activity, and Structure of a Highly Specific Artificial Endonuclease

2002 • 232 citations

Wet and dry interfaces: the role of solvent in protein–protein and protein–DNA recognition

1999 • 217 citations

Structural Plasticity in a Remodeled Protein-Protein Interface

1997 • 181 citations

Review: Protein Design—Where We Were, Where We Are, Where We're Going

2001 • 122 citations

Analysis of protein-protein interactions and the effects of amino acid mutations on their energetics. The importance of water molecules in the binding epitope

1997 • 76 citations

‘Omic’ approaches for unraveling signaling networks

2002 • 73 citations

Electrostatics significantly affect the stability of designed homeodomain variants

2002 • 71 citations

ProTherm, Thermodynamic Database for Proteins and Mutants: developments in version 3.0

2002 • 64 citations

Dissection of the protein G B1 domain binding site for human IgG Fc fragment

1999 • 50 citations

Calculation of HyHel10-lysozyme binding free energy changes: Effect of ten point mutations

1998 • 46 citations