Keratinocyte–Fibroblast Interactions in Wound Healing

Seria cultivation of strains of human epidemal keratinocytes: the formation keratinizin colonies from single cell is

1975 • 4,443 citations

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

Regulation of Wound Healing by Growth Factors and Cytokines

2003 • 3,383 citations

Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis

1990 • 2,262 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

Defining the Epithelial Stem Cell Niche in Skin

2003 • 1,995 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Receptor Specificity of the Fibroblast Growth Factor Family

1996 • 1,871 citations

Friends or foes — bipolar effects of the tumour stroma in cancer

2004 • 1,742 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Three clonal types of keratinocyte with different capacities for multiplication.

1987 • 1,271 citations

Receptor Specificity of the Fibroblast Growth Factor Family

2006 • 1,103 citations

Diversity, topographic differentiation, and positional memory in human fibroblasts

2002 • 1,082 citations

Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer

2006 • 1,075 citations

Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

2001 • 998 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation

2001 • 605 citations

Large induction of keratinocyte growth factor expression in the dermis during wound healing.

1992 • 603 citations

The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds

1994 • 597 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Parallels between tissue repair and embryo morphogenesis

2004 • 554 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice

2003 • 532 citations

Morphological and immunochemical differences between keloid and hypertrophic scar.

1994 • 522 citations

Molecular principles of hair follicle induction and morphogenesis

2005 • 520 citations

Neutralising antibody to TGF-β1,2 reduces cutaneous scarring in adult rodents

1994 • 499 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

DIFFERENTIAL REGULATION OF PRO-INFLAMMATORY CYTOKINES DURING WOUND HEALING IN NORMAL AND GLUCOCORTICOID-TREATED MICE

1996 • 492 citations

Anatomic Demarcation by Positional Variation in Fibroblast Gene Expression Programs

2006 • 463 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

2000 • 412 citations

Mutual induction of growth factor gene expression by epidermal-dermal cell interaction

1993 • 401 citations

Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice

2000 • 400 citations

A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA

2000 • 397 citations

Fibroblasts in Mechanically Stressed Collagen Lattices Assume a “Synthetic” Phenotype

2001 • 368 citations

Transforming Growth Factors β1, β2, and β3 and Their Receptors Are Differentially Regulated during Normal and Impaired Wound Healing

1996 • 349 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury.

1993 • 334 citations

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

2006 • 314 citations

Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution

2003 • 295 citations

Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing

2005 • 295 citations

Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism

1999 • 288 citations

Release of Mechanical Tension Triggers Apoptosis of Human Fibroblasts in a Model of Regressing Granulation Tissue

1999 • 282 citations

Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth

1991 • 260 citations

Dynamics of Basement Membrane Formation by Keratinocyte–Fibroblast Interactions in Organotypic Skin Culture

1998 • 256 citations

Accelerated wound healing in tumor necrosis factor receptor p55‐deficient mice with reduced leukocyte infiltration

2002 • 250 citations

Cellular origin of the dermal‐epidermal basement membrane

1993 • 244 citations

Reduced Expression of PDGF and PDGF Receptors During Impaired Wound Healing

1997 • 241 citations

Direct evidence for spatial and temporal regulation of transforming growth factor β1 expression during cutaneous wound healing

1991 • 230 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Cultured dermal papilla cells induce follicle formation and hair growth by transdifferentiation of an adult epidermis

1992 • 220 citations

Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.

1991 • 220 citations

Regulation of keratinocyte growth factor gene expression by interleukin 1.

1994 • 217 citations

Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

1999 • 209 citations

Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts.

1994 • 203 citations

Wound-Healing Studies in Transgenic and Knockout Mice

2004 • 193 citations

Strong Induction of Activin Expression after Injury Suggests an Important Role of Activin in Wound Repair

1996 • 191 citations

Modulation of Collagen Synthesis by Transforming Growth Factor-β in Keloid and Hypertrophic Scar Fibroblasts

1994 • 189 citations

Spatial and temporal patterns of immunoreactive transforming growth factor beta 1, beta 2, and beta 3 during excisional wound repair.

1993 • 176 citations

Tumor Necrosis Factor-α Inhibits Transforming Growth Factor-β /Smad Signaling in Human Dermal Fibroblasts via AP-1 Activation

2000 • 172 citations

Myofibroblast Differentiation Is Induced in Keratinocyte-Fibroblast Co-Cultures and Is Antagonistically Regulated by Endogenous Transforming Growth Factor-β and Interleukin-1

2004 • 172 citations

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

2001 • 171 citations

Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.

1995 • 165 citations

Activated keratinocytes in the epidermis of hypertrophic scars.

1998 • 156 citations

Human keratinocytes are a major source of cutaneous platelet-derived growth factor.

1993 • 149 citations

EGF and TGF‐alpha are potent chemoattractants for endothelial cells and EGF‐like peptides are present at sites of tissue regeneration

1989 • 142 citations

Sustained nontumorigenic phenotype correlates with a largely stable chromosome content during long-term culture of the human keratinocyte line HaCaT

1997 • 142 citations

Regulation of fibroblast-mediated collagen gel contraction by platelet-derived growth factor, interleukin-1 α and transforming growth factor-β1

1992 • 142 citations

Making digit patterns in the vertebrate limb

2005 • 140 citations

Fibroblasts facilitate re-epithelialization in wounded human skin equivalents

2003 • 138 citations

Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA

2004 • 138 citations

Normal Human Primary Fibroblasts Undergo Apoptosis in Three-Dimensional Contractile Collagen Gels

1998 • 130 citations

Mechanical Tension and Integrin α2β1 Regulate Fibroblast Functions

2006 • 130 citations

TGF‐β_S and TGF‐β type II receptor in human epidermis: Differential expression in acute and chronic skin wounds

1993 • 122 citations

Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression

1997 • 122 citations

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

2000 • 121 citations

Resistance of keratinocytes to TGFβ-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds

2002 • 121 citations

Epidermal tissue regeneration and stromal interaction in HaCaT cells is initiated by TGF-α

2003 • 119 citations

Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts

2005 • 107 citations

Epithelial origin of cutaneous anchoring fibrils.

1990 • 106 citations

Differential Proliferation of Rat Lung Fibroblasts Induced by the Platelet-derived Growth Factor-AA, -AB, and -BB Isoforms Secreted by Rat Alveolar Macrophages

1991 • 103 citations

Bone Marrow Stromal Cells, Preadipocytes, and Dermal Fibroblasts Promote Epidermal Regeneration in Their Distinctive Fashions

2004 • 102 citations

Active Transforming Growth Factor-β in Wound Repair

1999 • 96 citations

Studies on cytokines related to wound healing in donor site wound fluid

1995 • 96 citations

Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1

1996 • 94 citations

Complex epithelial–mesenchymal interactions modulate transforming growth factor‐β expression in keloid‐derived cells

2004 • 93 citations

Control of scarring in adult wounds using antisense transforming growth factor‐β1 oligodeoxynucleotides

1996 • 93 citations

The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair

2005 • 90 citations

Interleukin-1-Induced Growth Factor Expression in Postmitotic and Resting Fibroblasts.

1996 • 90 citations

Co-Culture of Human Keratinocytes on Post-Mitotic Human Dermal Fibroblast Feeder Cells: Production of Large Amounts of Interleukin 6

1992 • 85 citations

Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

2005 • 82 citations

Dissecting the roles of endothelin,TGF-β and GM-CSF on myofibroblast differentiation by keratinocytes

2004 • 81 citations

Repression of transforming-growth-factor-β-mediated transcription by nuclear factor κB

2000 • 80 citations

Phenotypic differences between dermal fibroblasts from different body sites determine their responses to tension and TGFβ1

2002 • 79 citations

Wound healing in the transforming growth factor‐β₁—deficient mouse

1995 • 78 citations

Role of Growth Factors in Scar Contraction

1996 • 74 citations

Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle

2001 • 73 citations

Activation of NF?B signal pathways in keloid fibroblasts

2004 • 72 citations

Dietary Compounds Inhibit Proliferation and Contraction of Keloid and Hypertrophic Scar-Derived Fibroblasts In Vitro

2003 • 71 citations

Neutrophils Express Tumor Necrosis Factor-α During Mouse Skin Wound Healing

1995 • 70 citations

Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing

2002 • 68 citations

Myofibroblast phenotype and apoptosis in keloid and palmar fibroblasts in vitro

2000 • 68 citations

Contraction-Dependent Apoptosis of Normal Dermal Fibroblasts

2001 • 67 citations

Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers

2002 • 63 citations

The role of the activin system in keloid pathogenesis

2006 • 59 citations

Expression of growth factor and receptor mRNAs in skin epithelial cells following acute cutaneous injury.

1993 • 58 citations

Fibroblast growth factor 22 and its potential role during skin development and repair

2003 • 57 citations

Wound epithelialization deficits in the transforming growth factor‐α knockout mouse

2001 • 56 citations

Oral fibroblasts produce more HGF and KGF than skin fibroblasts in response to co‐culture with keratinocytes

2002 • 49 citations

There Is Temporal and Spatial Expression of α1 (IV), α2 (IV), α5 (IV), α6 (IV) Collagen Chains and β1 Integrins During the Development of the Basal Lamina in an “In Vitro” Skin Model

1997 • 47 citations

Effects of Subepithelial Fibroblasts on Epithelial Differentiation in Human Skin and Oral Mucosa: Heterotypically Recombined Organotypic Culture Model

2003 • 46 citations

The myofibroblast, cadherin, α smooth muscle actin and the collagen effect

2004 • 45 citations

Activin A Induces Terminal Differentiation of Cultured Human Keratinocytes

1999 • 42 citations

Role for gap junctional intercellular communications in wound repair

2003 • 33 citations

Endogeneously regulated site-specific differentiation of human palmar skin keratinocytes in organotypic cocultures and in nude mouse transplants.

1996 • 22 citations

Postmitotic human dermal fibroblasts preserve intact feeder properties for epithelial cell growth after long-term cryopreservation

1990 • 14 citations