Resistance of keratinocytes to TGFβ-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds

Genomic sequencing.

1984 • 8,343 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Wound Healing--Aiming for Perfect Skin Regeneration

1997 • 4,630 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

Transforming growth factor βs and wound healing

1997 • 623 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1994 • 571 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.

1994 • 478 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model.

1991 • 355 citations

Transforming Growth Factors β1, β2, and β3 and Their Receptors Are Differentially Regulated during Normal and Impaired Wound Healing

1996 • 349 citations

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.

1988 • 324 citations

Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.

1995 • 324 citations

High-level expression of Egr-1 and Egr-1–inducible genes in mouse and human atherosclerosis

2000 • 293 citations

Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

1993 • 252 citations

Hypoxia-associated Induction of Early Growth Response-1 Gene Expression

1999 • 250 citations

TGF-β1 Stimulates Expression of Keratinocyte Integrins During Re-Epithelialization of Cutaneous Wounds

1994 • 246 citations

Induction of Apoptosis by c-Fos Protein

1996 • 224 citations

TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.

1995 • 209 citations

New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury

1999 • 204 citations

Egr-1 Activates Basic Fibroblast Growth Factor Transcription

1996 • 197 citations

Fluid shear stress activation of egr-1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal-related kinase 1/2 mitogen-activated protein kinase pathway.

1998 • 196 citations

Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium

1999 • 179 citations

Early Growth Response-1-dependent Apoptosis Is Mediated by p53

1997 • 172 citations

Fate of human keratinocytes during reepithelialization in an organotypic culture model.

1994 • 169 citations

Stimulatory Effects of Transforming Growth Factor-beta and Epidermal Growth Factor on Epidermal Cell Outgrowth from Porcine Skin Explant Cultures

1988 • 165 citations

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

1996 • 155 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues

1990 • 143 citations

The Transcription Factor EGR-1 Directly Transactivates the Fibronectin Gene and Enhances Attachment of Human Glioblastoma Cell Line U251

2000 • 141 citations

Expression of a dominant-negative type II transforming growth factor β (TGF-β) receptor in the epidermis of transgenic mice blocks TGF-β-mediated growth inhibition

1997 • 134 citations

A dominant-negative receptor for type beta transforming growth factors created by deletion of the kinase domain

1993 • 131 citations

Therapeutic approaches to organ fibrosis

1997 • 127 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

The Transcription Factor EGR-1 Suppresses Transformation of Human Fibrosarcoma HT1080 Cells by Coordinated Induction of Transforming Growth Factor-β1, Fibronectin, and Plasminogen Activator Inhibitor-1

1999 • 111 citations

Molecular cloning and characterization of mutant and wild-type human beta-actin genes.

1984 • 108 citations

Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages

2001 • 108 citations

Role of EGR-1 in Thapsigargin-Inducible Apoptosis in the Melanoma Cell Line A375-C6

1995 • 107 citations

Differential gene expression in migrating renal epithelial cells after wounding

1995 • 95 citations

Nerve growth factor induces transcription of transforming growth factor-beta 1 through a specific promoter element in PC12 cells.

1994 • 93 citations

Effect of TGF-β1 on Re-Epithelialization of Human Keratinocytes In Vitro: An Organotypic Model

1994 • 77 citations

Role for Bcl-xLin the Regulation of Apoptosis by EGF and TGFβ1 in c-myc Overexpressing Mammary Epithelial Cells

1996 • 75 citations

Tissue Repair with a Therapeutic Transcription Factor

2000 • 73 citations

The Transcription Factor Early Growth Response 1 (Egr-1) Advances Differentiation of Pre-B and Immature B Cells

1998 • 64 citations

Physical interaction between p53 and primary response gene Egr-1

2001 • 60 citations

Elevated Egr-1 in Human Atherosclerotic Cells Transcriptionally Represses the Transforming Growth Factor-β Type II Receptor

2000 • 57 citations

Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor

2000 • 56 citations

Epidermal overexpression of granulocyte-macrophage colony-stimulating factor induces both keratinocyte proliferation and apoptosis.

2000 • 55 citations

Stimulation of Keratinocyte Migration by Growth Factors

1992 • 48 citations

Expression and prognostic value of Wilms' tumor 1 and early growth response 1 proteins in nephroblastoma.

2000 • 43 citations

Further Observations on Epithelialization of Small Wounds

1970 • 34 citations

An S1 nuclease-sensitive homopurine/homopyrimidine domain in the PDGF A-chain promoter contains a novel binding site for the growth factor-inducible protein EGR-1

1992 • 29 citations

Immediate Early Gene Responses of NIH 3T3 Fibroblasts and NMuMG Epithelial Cells to TGFβ-1

1991 • 21 citations

Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor

2000 • 3 citations