The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Substituent Constants for Correlation Analysis in Chemistry and Biology.

1980 • 2,780 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

The Pharmacological Basis of Therapeutics

1986 • 2,365 citations

The α/β hydrolase fold

1992 • 2,024 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Molecular and cellular biology of cholinesterases

1993 • 1,192 citations

A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex

1991 • 1,112 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

The Cholinesterases: From Genes to Proteins

1994 • 650 citations

Acetylcholine Binding by a Synthetic Receptor: Implications for Biological Recognition

1990 • 608 citations

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors

1983 • 580 citations

Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase

1992 • 503 citations

Enzymatic Catalysis and Transition-State Theory

1973 • 501 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1993 • 431 citations

Transition States of Biochemical Processes

1978 • 418 citations

Transition State Analogues for Enzyme Catalysis

1969 • 381 citations

Understanding the rates of certain enzyme-catalyzed reactions: Proton abstraction from carbon acids, acyl transfer reactions, and displacement reactions of phosphodiesters

1993 • 352 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket

1993 • 329 citations

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

1992 • 286 citations

Molecular recognition in aqueous media. New binding studies provide further insights into the cation-.pi. interaction and related phenomena

1993 • 271 citations

Analogs of Reaction Intermediates Identify a Unique Substrate Binding Site in Candida rugosa Lipase

1994 • 259 citations

Ab initio and Monte Carlo calculations for a nucleophilic addition reaction in the gas phase and in aqueous solution

1986 • 184 citations

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

1992 • 183 citations

Impact-Induced Cleaving and Melting of Alkali-Halide Nanocrystals

1991 • 177 citations

A Family of Protein-Cutting Proteins

1974 • 157 citations

Fragmentations of gas-phase complexes between alkali metal ions and peptides: metal ion binding to carbonyl oxygens and other neutral functional groups

1991 • 154 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

1986 • 133 citations

Multidisciplinary Approaches to Cholinesterase Functions

1992 • 128 citations

Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium.

1990 • 111 citations

Catalysis by acetylcholinesterase: evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis.

1975 • 85 citations

Facile synthesis, spectral characterization, and ethylidene transfer reactions of complexes of the type Cp(CO)(L)Fe:CHCH3+

1981 • 77 citations

Acetylcholinesterase: structure and use as a model for specific cation—protein interactions

1992 • 77 citations

5 A cetykholinesterase

1971 • 76 citations

Conformational Relationship between the O–C–C–N+ System of Phospholipids and Substrates of Muscarinic and Cholinergic Systems

1968 • 75 citations

Kinetics of acetylthiocholine binding to electric eel acetylcholinesterase in glycerol/water solvents of increased viscosity Evidence for a diffusion-controlled reaction

1982 • 62 citations

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine

1975 • 58 citations

Origins and Diversity of the Aging Reaction in Phosphonate Adducts of Serine Hydrolase Enzymes: What Characteristics of the Active Site do They Probe?

1995 • 48 citations

NMR studies on the conformation of acetylcholine isologues

1970 • 47 citations

Structural parameters determining cholinergic and anticholinergic activities in a series of 1,3-dioxolanes

1972 • 45 citations

The Solidification of Castings

1974 • 43 citations

Evidence for active intermediates during the reconstitution of yeast phosphoglycerate mutase

1985 • 40 citations

19F-NMR spectral evidence that 3-octylthio-1,1,1-trifluoropropan-2-one, a potent inhibitor of insect juvenile hormone esterase, functions as a transition state analog inhibitor of acetylcholinesterase

1988 • 38 citations

Crystal structure at 1.5-.ANG. resolution of d(CGCICICG), an octanucleotide containing inosine, and its comparison with d(CGCG) and d(CGCGCG) structures

1992 • 37 citations

Hemiacetal anions: a model for tetrahedral reaction intermediates

1991 • 32 citations

Modification of Transcription following Interaction of Template Specific Monomers of Bacillus subtilis RNA Polymerase

1969 • 31 citations

Parallel mechanisms in acetylcholinesterase-catalyzed hydrolysis of choline esters

1993 • 29 citations

Multinuclear magnetic resonance studies on serine protease transition state analogues

1989 • 28 citations

Simple general acid-base catalysis of physiological acetylcholinesterase reactions

1992 • 27 citations

Base-catalyzed and cholinesterase-catalyzed hydrolysis of acetylcholine and optically active analogs

1975 • 20 citations

Anatomy of acetylcholinesterase catalysis: reaction dynamics analogy for human erythrocyte and electric eel enzymes

1990 • 17 citations

Structure of acetylcholine tetraphenylborate

1980 • 16 citations

ChemInform Abstract: Chemisorption Patterns as Predicted by Band Calculations, by Frontier Crystal Orbitals, and by Cluster Calculations: Hydrogen Atoms on Graphite

1986 • 16 citations

Acetylcholinesterase-catalyzed hydrolysis of anilides: acylation reaction dynamics and intrinsic chemical transition-state structures

1987 • 10 citations

Comparison of the Hypotensive Activities of Highly Hindered Open-Chain Amines and Their Cyclic Counterparts

1966 • 8 citations

Cyclobutane analogs of acetyl-.gamma.-homocholine

1973 • 8 citations

Conformational aspects of systems related to acetylcholine. 3. Base-catalyzed and acetycholinesterase-catalyzed hydrolysis of the isomeric dl-3-trimethylammonium-2-acetoxy-trans-decalin halides and the isomeric dl-1-methyl-3-acetoxy-trans-decahydroquinoline methiodides

1972 • 8 citations

Acetylcholinesterase inhibition by the ketone transition state analogs phenoxyacetone and 1-halo-3-phenoxy-2-propanones

1982 • 8 citations

Acetylcholinesterase Catalysis - Protein Engineering Studies

1992 • 7 citations

3-D Structure of Acetylcholinesterase and Complexes of it with Anticholinesterase Agents

1992 • 5 citations

Site-Directed Mutagenesis of Functional Residues in Torpedo Acetylcholinesterase

1992 • 4 citations