Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Structure and Mechanism in Protein Science

2017 • 2,079 citations

Structure and Mechanism in Protein Science

1998 • 1,918 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

Crystal Structure of Human Butyrylcholinesterase and of Its Complexes with Substrate and Products

2003 • 768 citations

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1993 • 431 citations

The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase

1996 • 360 citations

Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex

1995 • 347 citations

Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity

1993 • 311 citations

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

2000 • 302 citations

Three‐dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors

2000 • 290 citations

Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

1994 • 259 citations

Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1995 • 236 citations

Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

1992 • 220 citations

Acetylcholinesterase: Enthalpies and Entropies of Activation¹

1956 • 177 citations

ACETYLCHOLINESTERASE

1950 • 174 citations

Substrate Binding to the Peripheral Site of Acetylcholinesterase Initiates Enzymatic Catalysis. Substrate Inhibition Arises as a Secondary Effect

1998 • 164 citations

Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives.

1991 • 158 citations

Mutagenesis of essential functional residues in acetylcholinesterase.

1990 • 140 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

Site of fasciculin interaction with acetylcholinesterase

1994 • 135 citations

Role of Aspartate 70 and Tryptophan 82 in Binding of Succinyldithiocholine to Human Butyrylcholinesterase

1997 • 132 citations

Acetylthiocholine Binds to Asp74 at the Peripheral Site of Human Acetylcholinesterase as the First Step in the Catalytic Pathway

2000 • 132 citations

Molecular Mechanisms for Hydrolytic Enzyme Action. I. Apparent Non-competitive Inhibition, with Special Reference to Acetylcholinesterase

1961 • 111 citations

Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

1993 • 110 citations

The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 Å resolution by X-ray crystallography

1999 • 104 citations

Acetylcholinesterase engineering for detection of insecticide residues

2002 • 104 citations

Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine.

1984 • 97 citations

Acetylcholinesterase: Reversible Inhibitors, Substrate Inhibition

1962 • 97 citations

Nonequilibrium Analysis Alters the Mechanistic Interpretation of Inhibition of Acetylcholinesterase by Peripheral Site Ligands

1998 • 96 citations

“Back Door” Opening Implied by the Crystal Structure of a Carbamoylated Acetylcholinesterase

1999 • 91 citations

Detection of Anatoxin-a(s) in Environmental Samples of Cyanobacteria by Using a Biosensor with Engineered Acetylcholinesterases

2002 • 86 citations

Cloning and Expression of Acetylcholinesterase from Venom

1996 • 83 citations

Two invertebrate acetylcholinesterases show activation followed by inhibition with substrate concentration

1998 • 81 citations

Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase

1986 • 78 citations

Biochemical-Characterization of Drosophila melanogaster Acetylcholinesterase Expressed by Recombinant Baculoviruses

1994 • 72 citations

Drosophila acetylcholinesterase: demonstration of a glycoinositol phospholipid anchor and an endogenous proteolytic cleavage

1988 • 71 citations

Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase.

1994 • 62 citations

The “back door” hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis.

1994 • 56 citations

Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge

1998 • 53 citations

Molecular Mechanisms for Hydrolytic Enzyme Action. II. Inhibition of Acetyl-cholinesterase by Excess Substrate

1961 • 50 citations

Stabilization of RecombinantDrosophilaAcetylcholinesterase

1998 • 49 citations

Stabilization of Recombinant Drosophila Acetylcholinesterase

1998 • 48 citations

Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities.

1992 • 42 citations

Exploration of the Drosophila Acetylcholinesterase Substrate Activation Site Using a Reversible Inhibitor (Triton X-100) and Mutated Enzymes

2000 • 41 citations

Reversibly Bound and Covalently Attached Ligands Induce Conformational Changes in the Omega Loop, Cys69–Cys96, of Mouse Acetylcholinesterase

2001 • 40 citations

Involvement of Deacylation in Activation of Substrate Hydrolysis by Drosophila Acetylcholinesterase

2001 • 27 citations

Cholinesterase: substrate inhibition and substrate activation

2000 • 22 citations

The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases

1999 • 20 citations

Allosteric Control of Acetylcholinesterase Activity by Monoclonal Antibodies

1998 • 19 citations

Drosophila acetylcholinesterase: Effect of post-traductional modifications on the production in the baculovirus system and substrate metabolization

1998 • 17 citations

Allosteric Control of Acetylcholinesterase Activity by Monoclonal Antibodies

1999 • 16 citations

Acceleration of Drosophila melanogaster acetylcholinesterase methanesulfonylation: peripheral ligand d-tubocurarine enhances the affinity for small methanesulfonylfluoride

2002 • 6 citations