Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1995 • 5,246 citations

WHAT IF: A molecular modeling and drug design program

1990 • 3,484 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

1996 • 2,561 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Crystallographic evidence for the existence of CH.cntdot..cntdot..cntdot.O, CH.cntdot..cntdot..cntdot.N and CH.cntdot..cntdot..cntdot.Cl hydrogen bonds

1982 • 1,869 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

1986 • 453 citations

The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase

1996 • 360 citations

Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1995 • 236 citations

The Growth and Preliminary Investigation of Protein and Nucleic Acid Crystals for X‐ray Diffraction Analysis

1976 • 234 citations

(His)Cε-H···O=C< Hydrogen Bond in the Active Sites of Serine Hydrolases

1994 • 215 citations

Cholinergic Basis for Alzheimer Therapy

1991 • 177 citations

Crystal structure of a naturally occurring dinucleoside phosphate: Uridylyl 3′,5′-adenosine phosphate model for RNA chain folding

1972 • 172 citations

Structure and dynamics of the active site gorge of acetylcholinesterase: Synergistic use of molecular dynamics simulation and X‐ray crystallography

1994 • 170 citations

Tacrine

1995 • 168 citations

Efficient Rebuilding of Protein Structures

1996 • 148 citations

Chapter 49: Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia

1993 • 143 citations

Enzymes of the Cholinesterase Family

1995 • 141 citations

Mechanism of inhibition of cholinesterases by huperzine A

1992 • 135 citations

Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate

1997 • 116 citations

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

1988 • 105 citations

Identification of a More Potent Analogue of the Naturally Occurring Alkaloid Huperzine A. Predictive Molecular Modeling of Its Interaction with AChE

1996 • 105 citations

Prediction of the binding sites of huperzine A in acetylcholinesterase by docking studies

1994 • 98 citations

Synthesis of huperzine A, its analogs, and their anticholinesterase activity

1991 • 95 citations

[Drug evaluation of huperzine A in the treatment of senile memory disorders].

1991 • 70 citations

Alzheimer disease : therapeutic strategies

1994 • 66 citations

Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase

1991 • 60 citations

Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases

1994 • 48 citations

Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase.

1994 • 46 citations

Acute and chronic studies with the anticholinesterase huperzine a: Effect on central nervous system cholinergic parameters

1991 • 45 citations

Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity

1991 • 43 citations

The alkaloids huperzines C and D and huperzinine fromLycopodiastrum casuarinoides

1994 • 42 citations

Stereochemistry of charged nitrogen-aromatic interactions and its involvement in ligand-receptor binding

1993 • 41 citations

Effect of Huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats

1995 • 30 citations

Protein engineering of rubisco

1991 • 24 citations

Synthesis and biological evaluation of (±)-Z-huperzine A

1990 • 20 citations

Development of Drugs for Alzheimer Therapy: A Decade of Progress

1994 • 16 citations

Huperzine A – a potent acetylcholinesterase inhibitor of use in the treatment of Alzheimer's disease

1991 • 15 citations

Cognition Improvement by Oral Huperzine A: A Novel Acetylcholinesterase Inhibitor

1994 • 9 citations

Computer Modeling of Acetylcholinesterase and Acetylcholinesterase-Ligand Complexes

1995 • 3 citations