Allosteric Control of Acetylcholinesterase Catalysis by Fasciculin

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

Substituent constants for correlation analysis in chemistry and biology

1979 • 2,909 citations

Substituent Constants for Correlation Analysis in Chemistry and Biology.

1980 • 2,780 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1993 • 431 citations

Two conformational states of Candida rugosa lipase

1994 • 371 citations

Enzyme inhibitors as substrates

1974 • 348 citations

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket

1993 • 329 citations

Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity

1993 • 311 citations

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

1992 • 286 citations

Enzyme Inhibition in Relation to Chemotherapy.

1949 • 260 citations

Open "Back Door" in a Molecular Dynamics Simulation of Acetylcholinesterase

1994 • 259 citations

Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands

1980 • 189 citations

Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

1994 • 181 citations

Structure and dynamics of the active site gorge of acetylcholinesterase: Synergistic use of molecular dynamics simulation and X‐ray crystallography

1994 • 170 citations

Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives.

1991 • 158 citations

Current view on the structure-function relationship of postsynaptic neurotoxins from snake venoms

1987 • 147 citations

Enzymes of the Cholinesterase Family

1995 • 141 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

Site of fasciculin interaction with acetylcholinesterase

1994 • 135 citations

Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

1993 • 110 citations

Amino Acid Residues Controlling Reactivation of Organophosphonyl Conjugates of Acetylcholinesterase by Mono- and Bisquaternary Oximes

1995 • 100 citations

Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.

1994 • 91 citations

1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom.

1992 • 84 citations

1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom.

1992 • 77 citations

Molecular Recognition in Acetylcholinesterase Catalysis: Free-Energy Correlations for Substrate Turnover and Inhibition by Trifluoro Ketone Transition-State Analogs

1994 • 74 citations

Anticholinesterase toxins

1985 • 52 citations

Spectroscopic studies on acetylcholinesterase: influence of peripheral-site occupation on active-center conformation

1981 • 48 citations

m-(N,N,N-Trimethylammonio)trifluoroacetophenone: a femtomolar inhibitor of acetylcholinesterase

1993 • 47 citations

Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates

1979 • 40 citations

19F-NMR spectral evidence that 3-octylthio-1,1,1-trifluoropropan-2-one, a potent inhibitor of insect juvenile hormone esterase, functions as a transition state analog inhibitor of acetylcholinesterase

1988 • 38 citations

Theoretical analysis of the structure of the peptide fasciculin and its docking to acetylcholinesterase

1995 • 26 citations

Chimeric Human Cholinesterase

1993 • 21 citations

m-Alkyl, α,α,α-trifluoroacetophenones: A new class of potent transition state analog inhibitors of acetylcholinesterase

1993 • 15 citations