Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Enzyme structure and mechanism

1977 • 2,935 citations

XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density

1999 • 2,108 citations

Reduced surface: An efficient way to compute molecular surfaces

1996 • 1,864 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

Amino‐aromatic interactions in proteins

1986 • 752 citations

Structure of acetylcholinesterase complexed with E2020 (Aricept®): implications for the design of new anti-Alzheimer drugs

1999 • 688 citations

Aromatic rings act as hydrogen bond acceptors

1988 • 685 citations

Enzymatic Catalysis and Transition-State Theory

1973 • 501 citations

The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

1986 • 453 citations

Aspartate Transcarbamylase

1971 • 422 citations

The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase

1996 • 360 citations

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A

1997 • 360 citations

Chapter 53: Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease

1993 • 302 citations

Nicotinic System Involvement in Alzheimer??s and Parkinson??s Diseases

1997 • 265 citations

Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1995 • 236 citations

Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands.

1996 • 222 citations

Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo

1990 • 205 citations

Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21

1995 • 203 citations

Tacrine

1995 • 168 citations

The pharmacology of galanthamine and its analogues

1995 • 158 citations

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer’s disease: histotopographical correlation with amyloid plaques and hyperphosphorylated‐tau protein

1999 • 155 citations

Chapter 49: Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia

1993 • 143 citations

Structure-based drug design

1998 • 136 citations

Mechanism of inhibition of cholinesterases by huperzine A

1992 • 135 citations

Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons.

1993 • 122 citations

The rationale for E2020 as a potent acetylcholinesterase inhibitor

1996 • 119 citations

Chance Favors the Prepared Mind - From Serendipity to Rational Drug Design

1999 • 118 citations

Physostigmine, galanthamine and codeine act as ‘noncompetitive nicotinic receptor agonists’ on clonal rat pheochromocytoma cells

1995 • 117 citations

The Pharmacotherapy of Alzheimer's Disease Based on the Cholinergic Hypothesis: an Update

1995 • 104 citations

Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys

1998 • 101 citations

Potent acetylcholinesterase inhibitors: design, synthesis, and structure–Activity relationships of bis-interacting ligands in the galanthamine series

1998 • 101 citations

Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B

1990 • 77 citations

[Drug evaluation of huperzine A in the treatment of senile memory disorders].

1991 • 70 citations

The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

1998 • 66 citations

Modulation of acetylcholine release by nicotinic receptors in the rat brain

1989 • 45 citations

Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist

1997 • 43 citations

Annealing in crystallography: a powerful optimization tool

1999 • 26 citations

Oral physostigmine treatment for patients with presenile and senile dementia of the Alzheimer's type: a double-blind placebo-controlled trial.

1990 • 24 citations

In Vitro Muscarinic Activity of Spiromuscarones and Related Analogs

1995 • 16 citations

Commentary: Another piece of the Alzheimer's jigsaw.

1999 • 8 citations

Nivalin in the treatment of residual post-polio paralysis and pseudo-hypertrophic muscular dystrophy.

1965 • 4 citations