Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

An amplified sensitivity arising from covalent modification in biological systems.

1981 • 1,211 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2

1991 • 870 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.

1984 • 575 citations

The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system

1991 • 504 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Modeling the cell division cycle: cdc2 and cyclin interactions.

1991 • 456 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.

1991 • 413 citations

A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.

1980 • 358 citations

Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: Studies in Xenopus

1990 • 354 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.

1992 • 294 citations

Activation of the various cyclin/cdc2 protein kinases

1993 • 253 citations

Partial purification and characterization of the maturation-promoting factor from eggs of Xenopus laevis

1980 • 246 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

1990 • 222 citations

Regulation of MPF activity in vitro

1988 • 209 citations

Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

1993 • 186 citations

Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer

1993 • 184 citations

Coupling M phase and S phase: Controls maintaining the dependence of mitosis on chromosome replication

1991 • 183 citations

Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis.

1983 • 169 citations

Modeling the Cell Division Cycle: M-phase Trigger, Oscillations, and Size Control

1993 • 150 citations

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

1992 • 145 citations

Control of programmed cyclin destruction in a cell-free system.

1989 • 138 citations

A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity.

1989 • 126 citations

Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B

1992 • 119 citations

Mitotic control

1991 • 104 citations

Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts.

1992 • 91 citations

The control of DNA replication in a cell-free extract that recapitulates a basic cell cycle in vitro

1988 • 91 citations

A COMPARISON OF THE DEVELOPMENT OF NUCLEATE AND NON-NUCLEATE EGGS OF ARBACIA PUNCTULATA

1940 • 81 citations

Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.

1992 • 75 citations

Mitosis-inducing factors are present in a latent form during interphase in the Xenopus embryo.

1988 • 69 citations

Regulation of p34cdc2 protein kinase: new insights into protein phosphorylation and the cell cycle

1991 • 65 citations

Is molecular biology yet a science?

1992 • 62 citations

Multiple roles for protein phosphatase 1 in regulating the Xenopus early embryonic cell cycle.

1992 • 57 citations

Turning on mitosis

1993 • 44 citations

TIME-ZERO: The integrated modeling environment

1989 • 18 citations

DNA Replication and Progression Through the Cell Cycle

2007 • 10 citations