Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Signal transduction via the MAP kinases: proceed at your own RSK.

1993 • 1,262 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.

1993 • 675 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Oocyte Maturation

1979 • 662 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

1988 • 617 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

Progesterone-stimulated meiotic cell division in Xenopus oocytes. Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase.

1977 • 419 citations

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1994 • 388 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

The Product of the mos Proto-Oncogene as a Candidate "Initiator" for Oocyte Maturation

1989 • 333 citations

Cell cycle regulation of a Xenopus Wee1-like kinase.

1995 • 316 citations

The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but not MPF, in cell-free extracts of Xenopus oocytes and eggs.

1993 • 297 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.

1991 • 274 citations

Changes in protein phosphorylation accompanying maturation of Xenopus laevis oocytes

1977 • 269 citations

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

1992 • 264 citations

Meiotic initiation by the mos protein in Xenopus

1992 • 253 citations

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

1995 • 232 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.

1992 • 188 citations

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

1993 • 179 citations

STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast.

1990 • 178 citations

Mos induces the in vitro activation of mitogen-activated protein kinases in lysates of frog oocytes and mammalian somatic cells.

1993 • 168 citations

Induction of Xenopus Oocyte Meiotic Maturation by MAP Kinase

1995 • 154 citations

Requirement for Raf and MAP kinase function during the meiotic maturation of Xenopus oocytes

1993 • 150 citations

Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.

1991 • 144 citations

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes.

1992 • 134 citations

Induction by NGF of Meiotic Maturation of Xenopus Oocytes Expressing the trk Proto-Oncogene Product

1991 • 133 citations

A study of the induction of cell division in amphibian oocytes by insulin

1981 • 130 citations

Meiotic Maturation in Xenopus laevis Oocytes Initiated by Insulin

1979 • 128 citations

Protein kinase A acts at multiple points to inhibit Xenopus oocyte maturation.

1994 • 127 citations

Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos.

1993 • 120 citations

Phosphorylation of dis2 protein phosphatase at the C-terminal cdc2 consensus and its potential role in cell cycle regulation.

1994 • 119 citations

Biochemical and biological analysis of Mek1 phosphorylation site mutants.

1995 • 113 citations

Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.

1989 • 91 citations

Inhibition of mos-induced oocyte maturation by protein kinase A.

1993 • 81 citations

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

1993 • 76 citations

Activation of p34cdc2 kinase by cyclin is negatively regulated by cyclic Amp-dependent protein kinase in Xenopus oocytes

1992 • 53 citations

Oncogenic ras protein induces meiotic maturation of amphibian oocytes in the presence of protein synthesis inhibitors

1988 • 40 citations

Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes

1994 • 23 citations

tpr-met Oncogene Product Induces Maturation-Producing Factor Activation in Xenopus Oocytes

1991 • 21 citations