A novel immunodeficiency associated with hypomorphic RAG1 mutations and CMV infection

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

2002 • 1,583 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB

1999 • 1,006 citations

Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

2001 • 893 citations

Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children

1987 • 875 citations

Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)

1995 • 875 citations

Defective IL7R expression in T-B+NK+ severe combined immunodeficiency

1998 • 805 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

RAG Mutations in Human B Cell-Negative SCID

1996 • 530 citations

Activation of γδ T Cells in the Primary Immune Response to Mycobacterium tuberculosis

1989 • 463 citations

Partial V(D)J Recombination Activity Leads to Omenn Syndrome

1998 • 459 citations

Self-Recognition of Cd1 by γ/δ T Cells

2000 • 367 citations

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

2001 • 338 citations

Implication of γδ T cells in the human immune response to cytomegalovirus

1999 • 316 citations

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

2000 • 306 citations

T Cell Antigen Receptor Engagement and Specificity in the Recognition of Stress-Inducible MHC Class I-Related Chains by Human Epithelial γδ T Cells

2002 • 244 citations

Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study

2002 • 225 citations

Shared reactivity of Vδ2neg γδ T cells against cytomegalovirus-infected cells and tumor intestinal epithelial cells

2005 • 217 citations

Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues.

1989 • 215 citations

Identical mutations in RAG1 or RAG2 genes leading to defective V(D)J recombinase activity can cause either T-B–severe combined immune deficiency or Omenn syndrome

2001 • 214 citations

Congenital cytomegalovirus infection: Outcome and diagnosis

2005 • 205 citations

Effect of CD3δ Deficiency on Maturation of α/β and γ/δ T-Cell Lineages in Severe Combined Immunodeficiency

2003 • 205 citations

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling

2005 • 201 citations

Primary immunodeficiency diseases: An update

2004 • 192 citations

The Molecular Basis of X‐Linked Severe Combined Immunodeficiency: The Role of the Interleukin‐2 Receptor γ Chain as a Common γ Chain, γc

1994 • 180 citations

A Deletion in the Gene Encoding the CD45 Antigen in a Patient with SCID

2001 • 175 citations

T Cell Receptor–γ/δ Cells Protect Mice from Herpes Simplex Virus Type 1–induced Lethal Encephalitis

1997 • 173 citations

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome).

1991 • 168 citations

Increased γδ T cells in acute Plasmodium falciparum malaria

1990 • 163 citations

Predominant activation and expansion of V gamma 9-bearing gamma delta T cells in vivo as well as in vitro in Salmonella infection.

1992 • 154 citations

AIRE deficiency in thymus of 2 patients with Omenn syndrome

2005 • 145 citations

AIRE deficiency in thymus of 2 patients with Omenn syndrome

2005 • 144 citations

T Cell Receptor-Bearing Lymphocytes during Epstein-Barr Virus Infection

1990 • 138 citations

Major Expansion of γδ T Lymphocytes following Cytomegalovirus Infection in Kidney Allograft Recipients

1999 • 137 citations

Severe combined immunodeficiency caused by deficiency in either the δ or the ε subunit of CD3

2004 • 132 citations

Severe combined immunodeficiency caused by deficiency in either the δ or the ε subunit of CD3

2004 • 131 citations

Primary immunodeficiency diseases: an update

2003 • 129 citations

Expansion of Vγ9Vδ2 T Cells Is Triggered byFrancisella tularensis-Derived Phosphoantigens in Tularemia but Not after Tularemia Vaccination

1998 • 111 citations

Implication of gamma-delta T cells in the human immune response to cytomegalovirus

1999 • 96 citations

Adenosine Deaminase Deficiency

2012 • 93 citations

Highly restricted human T cell repertoire in peripheral blood and tissue-infiltrating lymphocytes in Omenn's syndrome.

1998 • 90 citations

Combination of MHC–peptide multimer-based T cell sorting with the Immunoscope permits sensitive ex vivo quantitation and follow-up of human CD8+ T cell immune responses

2002 • 88 citations

The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteins

2002 • 77 citations

Mechanisms of Vδ1 γδ T Cell Activation by Microbial Components

2004 • 68 citations

N-terminal RAG1 frameshift mutations in Omenn's syndrome: Internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains

2000 • 66 citations

Identification of the complete expressed human TCR V gamma repertoire by flow cytometry

1997 • 65 citations

N-terminal truncated human RAG1 proteins can direct T-cell receptor but not immunoglobulin gene rearrangements

2000 • 62 citations

Vγ1⁺γδ T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon‐γ

2000 • 60 citations

A mutation in Bruton’s tyrosine kinase as a cause of selective anti-polysaccharide antibody deficiency

2001 • 54 citations

Three-dimensional Clustering of Human RAG2 Gene Mutations in Severe Combined Immune Deficiency

2000 • 50 citations

Infantile Cytomegalovirus-Associated Autoimmune Hemolytic Anemia

2001 • 34 citations

Elevated numbers of gamma-delta (??+) T lymphocytes in children with immune thrombocytopenic purpura

1994 • 31 citations

Identification of anti–herpes simplex virus antibody–producing B cells in a patient with an atypical RAG1 immunodeficiency

2001 • 22 citations

Acute Primary Infection with Cytomegalovirus (CMV) in Kidney Transplant Recipients Results in the Appearance of a Phenotypically Aberrant CD8⁺ T Cell Population

2000 • 14 citations

A Deletion in the Gene Encoding the CD45 Antigen in a Patient with SCID

2002 • 3 citations

N-terminal truncated human RAG1 proteins can direct T-cell receptor but not immunoglobulin gene rearrangements

2000 • 2 citations